Extreme Physiology Extreme Tolerance to Hypoxia, Hypercapnia, and Pain in the Naked Mole-Rat [0.03%]
极端生理机能极高的缺氧、高二氧化碳和疼痛耐受力的无毛 mole-rat
Thomas J Park,Jane Reznick
Thomas J Park
Challenging environmental conditions can drive the evolution of extreme physiological traits. The naked mole-rat has evolved to survive and thrive in a low oxygen, high carbon dioxide environment that would be deadly to humans and most othe...
Myosin assembly of smooth muscle: from ribbons and side polarity to a row polar helical model [0.03%]
平滑肌肌球蛋白组装模型：从带状和侧面极性到行极螺旋模型
Isabel J Sobieszek,Apolinary Sobieszek
Isabel J Sobieszek
After decades of debate over the structure of smooth muscle myosin filaments, it is still unclear whether they are helical, as in all other muscle types, or square in shape. In both cases bipolar building units are proposed, but the deduced...
50 Years of the steric-blocking mechanism in vertebrate skeletal muscle: a retrospective [0.03%]
论脊椎动物骨骼肌的立体位阻机制：回顾与展望（纪念该机制提出五十周年）
David A D Parry
David A D Parry
Fifty years have now passed since Parry and Squire proposed a detailed structural model that explained how tropomyosin, mediated by troponin, played a steric-blocking role in the regulation of vertebrate skeletal muscle. In this Special Iss...
The effect of muscle length on post-tetanic potentiation of C57BL/6 and skMLCK-/- mouse EDL muscles [0.03%]
肌纤维长度对C57BL/6和skMLCK-/-小鼠EDL肌肉 tetanus 后增强效果的影响
Angelos Angelidis,Rene Vandenboom
Angelos Angelidis
Post-tetanic potentiation of fast-twitch skeletal muscle is dependent on muscle length, with greater potentiation observed at shorter compared to longer lengths. The structural effects of the primary potentiation mechanism, phosphorylation ...
Elevated mir-145-5p is associated with skeletal muscle dysfunction and triggers apoptotic cell death in C2C12 myotubes [0.03%]
升高的miR-145-5p与骨骼肌功能障碍相关，并在C2C12肌管中触发细胞凋亡死亡
Jing Jin,Fanyi Li,Caihong Fan et al.
Jing Jin et al.
Skeletal muscle dysfunction is a common comorbidity of chronic obstructive pulmonary disease (COPD), and the molecular mechanisms regarding to the pathogenesis of this disease have not been elucidated. In this study, a novel miR-145-5p was ...
Virtually "muscling" in pandemic: first virtual European Muscle Conference (September 20-22, 2021) [0.03%]
疫情之下肌论线上说——首届欧洲虚拟肌肉大会（2021年9月20-22日）
Maria Jolanta Rędowicz,Wolfgang A Linke
Maria Jolanta Rędowicz
A report on the first virtual European Muscle Conference. Keywords: Cardiac muscle; Cardiomyopathy; Muscle r...
Kapila Awasthi,Sudha Bhattacharya,Alok Bhattacharya
Kapila Awasthi
Mutations in the sialic acid biosynthesis enzyme GNE lead to a late-onset, debilitating neuromuscular disorder, GNE myopathy, characterized by progressive skeletal muscle weakness. The mechanisms responsible for skeletal muscle specificity,...
Mechanisms of weakness in Mdx muscle following in vivo eccentric contractions [0.03%]
离体拉长收缩对Mdx肌无力机制的影响
Cory W Baumann,Christopher P Ingalls,Dawn A Lowe
Cory W Baumann
Skeletal muscle of the dystrophin-deficient mdx mouse is hypersensitive to eccentric (ECC) contraction-induced strength loss due to plasmalemmal electrical dysfunction. Despite plasmalemmal inexcitability being a logical mechanism responsib...
Glutamine supplementation improves contractile function of regenerating soleus muscles from rats [0.03%]
谷氨酰胺补充改善大鼠再生腓肠肌的收缩功能
Tatiana E Koike,Rodrigo A Dell Aquila,Kellana S Silva et al.
Tatiana E Koike et al.
This study evaluated the effects of glutamine supplementation immediately after freezing injury on morphological and contractile function of regenerating soleus muscles from rats. Young male Wistar rats were subjected to cryolesion of soleu...
Effect of acute swimming exercise at different intensities but equal total load over metabolic and molecular responses in swimming rats [0.03%]
不同强度但总负荷相同的急性游泳运动对游泳大鼠代谢和分子反应的影响
Lucas Dantas Maia Forte,Natália de Almeida Rodrigues,André Vitor Cordeiro et al.
Lucas Dantas Maia Forte et al.
Acute metabolic and molecular response to exercise may vary according to exercise's intensity and duration. However, there is a lack regarding specific tissue alterations after acute exercise with aerobic or anaerobic predominance. The pres...