Aaron L Carrel,David B Allen
Aaron L Carrel
An increasingly pervasive environment of reduced activity and easy access to high caloric food is leading to an epidemic of poor cardiovascular fitness, obesity, insulin resistance and type 2 diabetes (T2DM) in children. Studies have shown ...
Annamaria Colao,Rosario Pivonello,Carolina Di Somma et al.
Annamaria Colao et al.
The efficacy of dopamine-agonists (DA) in patients with prolactinomas and that of somatostatin analogues (SSA) in those with GH- and TSH-secreting adenomas is well established. More recently, data are accumulating suggesting a potential the...
G Minniti,D C Gilbert,M Brada
G Minniti
Radiotherapy (RT) remains an effective treatment for residual or recurrent pituitary adenomas with excellent rates of tumour control and normalisation of excess hormone secretion. The main late toxicity is hypopituitarism: other side effect...
Alexandru Saveanu,Philippe Jaquet
Alexandru Saveanu
Somatostatin receptors (sst1-5) and dopamine receptor 2 (D2DR) are well expressed and co-localized in several human pituitary adenomas, suggesting possible functional interactions in the control of hormonal hypersecretion and tumor cell gro...
Somatostatin and dopamine receptors as targets for medical treatment of Cushing's Syndrome [0.03%]
生长抑素和多巴胺受体作为库欣综合征医学治疗的作用靶点
C de Bruin,R A Feelders,S W J Lamberts et al.
C de Bruin et al.
Somatostatin (SS) and dopamine (DA) receptors are widely expressed in neuroendocrine tumours that cause Cushing's Syndrome (CS). Increasing knowledge of specific subtype expression within these tumours and the ability to target these recept...
Vita Birzniece,Akira Sata,Ken K Y Ho
Vita Birzniece
Growth hormone (GH) regulates somatic growth, substrate metabolism and body composition. Its actions are elaborated through the GH receptor (GHR). GHR signalling involves the role of at least three major pathways, STATs, MAPK, and PI3-kinas...
Potential of retinoic acid derivatives for the treatment of corticotroph pituitary adenomas [0.03%]
视黄酸衍生物治疗促肾上腺皮质激素分泌垂体腺瘤的潜力
Marta Labeur,Marcelo Paez-Pereda,Eduardo Arzt et al.
Marta Labeur et al.
Cushing's disease is a severe clinical condition caused by hypersecretion of corticosteroids due to excessive ACTH secretion from a pituitary adenoma. This complex endocrine disorder still represents a major challenge for the physician in t...
J A M J L Janssen
J A M J L Janssen
Growth hormone (GH) is the primary regulator of insulin-like growth factor-I (IGF-I) production in a wide variety of tissues. There is much overlap in the endocrine, metabolic and anabolic effects of GH and IGF-I but both hormones have dive...
Potential role of type I interferons in the treatment of pituitary adenomas [0.03%]
I型干扰素在垂体腺瘤治疗中的潜在作用
Giovanni Vitale,Michele Caraglia,Peter M van Koetsveld et al.
Giovanni Vitale et al.
Cytokines, particularly those endowed with pro-inflammatory properties, are known to influence the release of anterior pituitary hormones by a direct and indirect action at the level of pituitary gland and hypothalamus. Type I interferons (...