Endocrine-disrupting chemicals in cosmetics: mechanistic insights and their impact on human and skin health [0.03%]
化妆品中的内分泌干扰化学物质：机制见解及其对人类和皮肤健康的影响
Charu Tomar,Pratichi Singh,Shikha Yadav
Charu Tomar
The increasing use of cosmetics and therapeutic products has raised concerns about their effects on skin health and overall well-being. This review focuses on the toxicological impact of cosmetic ingredients, particularly endocrine-disrupti...
Retroelements in thyroid cancer: epigenetic plasticity, dedifferentiation, and therapeutic opportunities [0.03%]
甲状腺癌中的逆转录元件：表观遗传塑性、去分化和治疗机会
Nathália Da Roz D&#x;Alessandre,Bruna Sousa Pessoa,Gabriela Der Agopian Guardia et al.
Nathália Da Roz D&#x;Alessandre et al.
Thyroid tumors display remarkable phenotypic plasticity, particularly in their progression from well-differentiated forms to aggressive, dedifferentiated subtypes such as anaplastic thyroid carcinoma. While genetic drivers such as BRAF, TP5...
LEAP2 as a therapeutic target in obesity and cardiometabolic disorders [0.03%]
LEAP2在肥胖和心血管代谢性疾病治疗中的靶点作用研究
Stephanie K Holm,Valdemar Brimnes Ingemann Johansen,Christoffer Clemmensen
Stephanie K Holm
Obesity is a global public health challenge intimately linked to cardiometabolic complications. Although current anti-obesity medications can produce substantial and rapid weight loss, their discontinuation often results in rapid weight reg...
Optimal dose and effectiveness of different types of physical activity to improve blood pressure in people with type 2 diabetes mellitus: A systematic review and network meta-analysis [0.03%]
不同种类的运动改善2型糖尿病患者血压的最佳剂量和效果：系统评价和网状Meta分析
Francisco Álvarez-Barbosa,Javier Ramos-Munell,Jesús Del Pozo-Cruz et al.
Francisco Álvarez-Barbosa et al.
People with type 2 diabetes have higher rates of hypertension compared to the general population, Current guidelines do not consider the baseline blood pressure for activity prescription. This study aimed to evaluate and compare effects of ...
Hypothalamic actions of estrogens in the regulation of energy and glucose homeostasis [0.03%]
雌激素在能量和葡萄糖稳态调节中的下丘脑作用
Ismael González-García,Yong Xu
Ismael González-García
Estrogens are a group of steroid hormones that exert a key role in female sexual and reproductive development and function. Produced primarily in the ovaries, estrogens influence many different aspects of physiology such as temperature home...
Thierry Brue,Philippe Chanson,Delphine Drui et al.
Thierry Brue et al.
From identity to function: unveiling the cellular complexity of hypothalamic feeding circuits [0.03%]
从身份到功能：揭开下丘脑摄食回路细胞复杂性的面纱
Sheridan H Littleton,John A Tadross,Giles S H Yeo
Sheridan H Littleton
The hypothalamus is arguably the most complex part of the brain, with the greatest heterogeneity of cellular populations. It is an integration center for peripheral signals and external stimuli and plays a key role in coordinating a myriad ...
Metabolic reprogramming in diabetes and other endocrine and metabolic disorders: exploring the Warburg effect, ketones, and SGLT2 inhibitors [0.03%]
糖尿病及其他内分泌和代谢障碍中的代谢重构：探索瓦堡效应、酮体及SGLT2抑制剂
Pedro Carrera-Bastos,Marcel H A Muskiet,Fernando Mata-Ordoñez et al.
Pedro Carrera-Bastos et al.
The "Warburg effect", a metabolic adaptation observed in dividing cells, involves a shift from mitochondrial oxidative phosphorylation to cytoplasmic glucose metabolism. This metabolic process is characterized by increased cellular uptake o...
Bridging the gap: recommendations to accomplish transition from pediatric to adult care in adolescents living with obesity [0.03%]
跨越鸿沟：促进肥胖青少年从儿科转至成人期医疗护理的建议
Albert Goday,Gilberto Pérez,Amanda Fernández et al.
Albert Goday et al.
Childhood obesity is a significant concern and its chronic nature results in an increased risk of adulthood obesity. Poorly planned transition from pediatric to adult care may contribute to poor outcomes. Failed transition may result in los...
Hypothalamic control of puberty: from neuronal circuits to mechanisms for its metabolic regulation [0.03%]
下丘脑控制青春期：从神经环路到代谢调控机制
Manuel Jimenez-Puyer,Verónica Sobrino,William H Colledge et al.
Manuel Jimenez-Puyer et al.
The hypothalamus is a singular brain region with essential roles in the control of a wide diversity of vegetative functions, from growth and energy balance to reproduction. These processes are governed by interconnected neuroendocrine pathw...