Endothelial dysfunction in diabetes mellitus: molecular mechanisms and clinical implications [0.03%]
糖尿病 mellitus中的内皮功能障碍：分子机制及临床意义
Corey E Tabit,William B Chung,Naomi M Hamburg et al.
Corey E Tabit et al.
Cardiovascular disease is a major complication of diabetes mellitus, and improved strategies for prevention and treatment are needed. Endothelial dysfunction contributes to the pathogenesis and clinical expression of atherosclerosis in diab...
Sihem Boudina,Evan Dale Abel
Sihem Boudina
Diabetes is associated with increased incidence of heart failure even after controlling for coronary artery disease and hypertension. Thus, as diabetic cardiomyopathy has become an increasingly recognized entity among clinicians, a better u...
E Michael Lewiecki
E Michael Lewiecki
Osteoporosis is a common disease characterized by low bone strength that increases the risk of fractures. The consequences of fractures include increases in morbidity, mortality, and healthcare costs. Randomized clinical trials have shown t...
Asamanja Chattoraj,Tiecheng Liu,Liang Samantha Zhang et al.
Asamanja Chattoraj et al.
Melatonin is a hormone secreted from the pineal gland specifically at night and contributes to a wide array of physiological functions in mammals. Melatonin is one of the most well understood output of the circadian clock located in the sup...
Nicoletta Sonino,Francesco Fallo,Giovanni A Fava
Nicoletta Sonino
There has been growing interest in the psychosocial aspects of Cushing's syndrome, such as the role of life stress as a pathogenetic factor, the association with affective disorders, and the presence of residual symptoms after treatment. In...
Ahmet Korkmaz,Turgut Topal,Dun-Xian Tan et al.
Ahmet Korkmaz et al.
Although the human genome has remained unchanged over the last 10,000 years, our lifestyle has become progressively more divergent from those of our ancient ancestors. This maladaptive change became apparent with the Industrial Revolution a...
Identification and treatment of metabolic complications in pediatric obesity [0.03%]
儿童肥胖代谢并发症的识别和治疗
Katie Larson Ode,Brigitte I Frohnert,Brandon M Nathan
Katie Larson Ode
Metabolic consequences of obesity including insulin resistance, type 2 diabetes mellitus, hyperlipidemia, hypertension, polycystic ovarian syndrome, and non-alcoholic fatty liver infiltration are rapidly emerging in the pediatric population...
Ronald C Hamdy
Ronald C Hamdy
Patients with osteoporosis have an increased risk of sustaining fractures because of the low bone mineral density (BMD) and altered bone micro-architecture which are characteristic features of the disease. Although a good correlation exists...
Willemijntje A Hoogerwerf
Willemijntje A Hoogerwerf
The molecular basis for biological rhythms is formed by clock genes. Clock genes are functional in the liver, within gastrointestinal epithelial cells and neurons of the enteric nervous system. These observations suggest a possible role for...
Melanie Rüger,Frank A J L Scheer
Melanie Rüger
The presence of day-night variations in cardiovascular and metabolic functioning is well known. However, only recently it has been shown that cardiovascular and metabolic processes are not only affected by the behavioral sleep/wake cycle bu...