I Karen Temple,Julian P H Shield
I Karen Temple
Transient Neonatal Diabetes (type 1) is the commonest cause of diabetes presenting in the first week of life. The majority of infants recover by 3 months of age but are predisposed to developing type 2 diabetes in later life. It is associat...
Kate Bennett,Chela James,Khalid Hussain
Kate Bennett
The pancreatic β-cell ATP-sensitive K(+) channel (K(ATP) channel) plays a critical role in glucose homeostasis by linking glucose metabolism to electrical excitability and insulin secretion. Changes in the intracellular ratio of ATP/ADP me...
Role of 18F-DOPA PET/CT imaging in congenital hyperinsulinism [0.03%]
18F-DOPA PET/CT显像在先天性高胰岛素血症中的作用
Dunia Ismail,Khalid Hussain
Dunia Ismail
Congenital hyperinsulinism is a leading cause of severe hypoglycaemia in the newborn period. There are two (diffuse and focal) histological subtypes of congenital hyperinsulinism. The diffuse form affects the entire pancreas and if medicall...
Mutations in pancreatic ß-cell Glucokinase as a cause of hyperinsulinaemic hypoglycaemia and neonatal diabetes mellitus [0.03%]
胰岛β细胞葡萄糖激酶基因突变引起高胰岛素血症性低血糖及新生儿糖尿病杂合子型
Khalid Hussain
Khalid Hussain
Glucokinase is a key enzyme involved in regulating insulin secretion from the pancreatic ß-cell. The unique role of glucokinase in human glucose physiology is illustrated by the fact that genetic mutations in glucokinase can either cause h...
Khalid Hussain
Khalid Hussain
This special edition of the Reviews in Metabolic and Endocrine Disorders provides a state of the state update on congenital hyperinsulinism and neonatal diabetes mellitus. Understanding the molecular mechanisms of these two disorders has pr...
Ty B Carroll,James W Findling
Ty B Carroll
Spontaneous Cushing's syndrome is well known but unusual clinical disorder. Many of the clinical features (central weight gain, glucose intolerance, hypertension, muscle weakness) are seen in other common conditions. Recognition of patients...
Dima Abdelmannan,David C Aron
Dima Abdelmannan
The issue of cortisol secretion by adrenal masses discovered incidentally in the course of evaluation for an unrelated reason (Subclinical Cushing's Syndrome) is among the most controversial and contentious issues in clinical endocrine prac...
Armand Krikorian,Mehreen Khan
Armand Krikorian
The Metabolic Syndrome is a diagnosis of increasing prevalence that is noted to share multiple clinical features with Cushing's syndrome. Several studies suggest abnormalities in the Hypothalamic-Pituitary-Adrenal axis to be associated with...
Dima AbdelMannan,Warren R Selman,Baha M Arafah
Dima AbdelMannan
Management of patients with ACTH producing pituitary adenoma remains to be challenging. Removal of the pituitary adenoma through transsphenoidal surgery is the main stay of treatment. Complete resection of the adenoma is followed by the dev...
The ectopic ACTH syndrome [0.03%]
异位ACTH综合征
Krystallenia I Alexandraki,Ashley B Grossman
Krystallenia I Alexandraki
Ectopic Cushing's syndrome usually relates to the ectopic ACTH syndrome (EAS) and represents ∼20% of ACTH-dependent and ∼10% of all types of Cushing's syndrome (CS). Nearly any neuroendocrine or non-endocrine tumours may be associated wit...