Niloufar Ilani,Ronald S Swerdloff,Christina Wang
Niloufar Ilani
An effective, safe, reversible, and acceptable method of contraception is an important component of reproductive health and provides the opportunity of shared responsibility for family planning for both partners. Female hormonal contracepti...
Putting risk into perspective: the US medical eligibility criteria for contraceptive use [0.03%]
认清利弊关系：美国避孕药具使用医学适宜性标准
Kathryn M Curtis,Naomi K Tepper,Polly A Marchbanks
Kathryn M Curtis
Unintended pregnancy remains a considerable problem in the United States, with health risks for both mother and infant. These risks may be increased among women with medical conditions, for whom pregnancy can lead to severe adverse outcomes...
Regine Sitruk-Ware,Anita Nath
Regine Sitruk-Ware
Estrogen and progestins have been used by millions of women as effective combined contraceptives. The safety of hormonal contraceptives has been documented by years of follow-up and serious adverse events that may be related to their use ar...
Alfredo Ulloa-Aguirre,Pascale Crépieux,Anne Poupon et al.
Alfredo Ulloa-Aguirre et al.
Gonadotropins play a central role in the control of male and female reproduction. Selective agonists and antagonists of gonadotropin receptors would be of great interest for the treatment of infertility or as non steroidal contraceptive. Ho...
Hellevi Peltoketo,Fu-Ping Zhang,Susana B Rulli
Hellevi Peltoketo
During the last two decades a large number of genetically modified mouse lines with altered gonadotropin action have been generated. These mouse lines fall into three categories: the lack-of-function mice, gain-of-function mice, and the mic...
John Funder
John Funder
Yoshiyu Takeda,Shigehoro Karashima,Takashi Yoneda
Yoshiyu Takeda
Primary aldosteronism (PA) has been recognized as a common cause of secondary hypertension and accounts for approximately 5-15% of the hypertensive population in Japan. Screening for PA should therefore be carried out in all hypertensive pa...
Gian Paolo D Rossi
Gian Paolo D Rossi
Primary aldosteronism involves more than 11% of hypertensive patients who are referred to specialized centers for the diagnosis and treatment of hypertension. If not diagnosed early it causes an excess damage to the heart, vessels and kidne...
Hypothalamic AMP-activated protein kinase as a mediator of whole body energy balance [0.03%]
作为全身能量平衡介导者的下丘脑AMP活化蛋白激酶
Pablo Blanco Martínez de Morentin,Carmen R González,Asisk K Saha et al.
Pablo Blanco Martínez de Morentin et al.
The AMP-activated protein kinase (AMPK) is the downstream constituent of a kinase cascade that acts as a sensor of cellular energy levels. Current data unequivocally indicate that hypothalamic AMPK plays a key role in the control of the who...