Fanny Chasseloup,Valérie Bernard,Philippe Chanson
Fanny Chasseloup
Prolactin (PRL) is a 23-kDa protein synthesized and secreted by lactotroph cells of the anterior pituitary gland but also by other peripheral tissues. PRL binds directly to a unique transmembrane receptor (PRLR), and the JAK2/signal transdu...
Yueyang Liu,Rong Fu,Hui Jia et al.
Yueyang Liu et al.
Growth hormone-releasing hormone (GHRH) is primarily produced by the hypothalamus and stimulates the release of growth hormone (GH) in the anterior pituitary gland, which subsequently regulates the production of hepatic insulin-like growth ...
Meal replacements on obesity and leptin: a systematic review and meta-analysis [0.03%]
代餐产品对肥胖与瘦素的影响：系统评价和meta分析
Somaye Fatahi,Danial Fotros,Mohammad Hassan Sohouli et al.
Somaye Fatahi et al.
The global prevalence of obesity and overweight is a significant concern in the field of public health. Numerous interventional studies have been conducted to assess the possible meal replacements (MRs) effect on anthropometric indicators a...
What do we know about abnormally low prolactin levels in polycystic ovary syndrome? A narrative review [0.03%]
多囊卵巢综合征患者低泌乳素血症的发病机制及影响：叙述性综述
Nicoletta Cera,Joana Pinto,Duarte Pignatelli
Nicoletta Cera
Hyper and hypoprolactinemia seem to be related to the occurrence of metabolic alterations in PCOS patients. In contrast, between significantly elevated and significantly low, prolactin levels seem to be protective against metabolic conseque...
Iacopo Gesmundo,Francesca Pedrolli,Renzhi Cai et al.
Iacopo Gesmundo et al.
The hypothalamic hormone growth hormone-releasing hormone (GHRH), in addition to promoting the synthesis and release of growth hormone (GH), stimulates the proliferation of human normal and malignant cells by binding to GHRH-receptor (GHRH-...
A novel approach for the treatment of AML, through GHRH antagonism: MIA-602 [0.03%]
一种通过生长激素释放因子拮抗治疗AML的新方法:MIA-602研究
Joel Costoya,Simonetta I Gaumond,Ravinder S Chale et al.
Joel Costoya et al.
Acute myeloid leukemia (AML) is the most aggressive and prevalent form of leukemia in adults. The gold-standard intervention revolves around the use of chemotherapy, and in some cases hematopoietic stem cell transplantation. Drug resistance...
Bryan Padraig Finn,Mehul T Dattani
Bryan Padraig Finn
Hypoprolactinaemia is an endocrinopathy which is typically encountered as part of a combined pituitary hormone deficiency picture. The vast majority of genetic causes identified to date have been in the context of congenital hypopituitarism...
The homeo-FIT-prolactin hypothesis: the role of prolactin in metabolic homeostasis - association or causality? [0.03%]
同源-FIT-催乳素假说：催乳素在代谢稳态中的作用-关联或因果关系？
Jesper Krogh
Jesper Krogh
The homeo-fit-prolactin hypothesis proposes a causal metabolic role for prolactin with hypoprolactinemia and hyperprolactinemia leading to adverse metabolic alterations. However, prolactin within the normal range and up to four times the up...
Clinical research progress on β-cell dysfunction in T2DM development in the Chinese population [0.03%]
我国糖尿病患者β细胞功能障碍的临床研究进展
Yibing Chen,Qian Jiang,Xiaowei Xing et al.
Yibing Chen et al.
The prevalence of type-2 diabetes mellitus (T2DM) has increased over 10-fold in the past 40 years in China, which now has the largest T2DM population in the world. Insulin resistance and β-cell dysfunction are the typical features of T2DM....
Agnieszka Siejka,Hanna Lawnicka,Saikat Fakir et al.
Agnieszka Siejka et al.
GHRH is a neuropeptide associated with a diverse variety of activities in human physiology and immune responses. The present study reviews the latest information on the involvement of GHRH in the immune system and inflammation, suggesting t...