Yin and Yang of hypothalamic insulin and leptin signaling in regulating white adipose tissue metabolism [0.03%]
下丘脑胰岛素和瘦素信号在调节白色脂肪组织代谢中的阴阳面
Thomas Scherer,Christoph Buettner
Thomas Scherer
Fatty acids released from white adipose tissue (WAT) provide important energy substrates during fasting. However, uncontrolled fatty acid release from WAT during non-fasting states causes lipotoxicity and promotes inflammation and insulin r...
Treatment of osteopenia [0.03%]
骨质疏松的治疗
Erik Fink Eriksen
Erik Fink Eriksen
The majority of osteoporotic fractures happen in individuals with BMD t-scores in the osteopenic range (-2,5< t-score 100) than in patients with fractured and t-score below -2,5 (NNT 10-20); 2)while specific osteoporosis treatments have dem...
Are circulating gonadotropin isoforms naturally occurring biased agonists? Basic and therapeutic implications [0.03%]
循环的促性腺激素同种型是偏向激动剂吗？基本含义及治疗意义
Brian J Arey,Francisco J López
Brian J Arey
The gonadotropins, luteinizing hormone, human chorionic gonadotropin and follicle-stimulating hormone, are key regulators of reproduction. As a result of this function, they have been the focus of research for many years. Isolated or recomb...
Stephanie Sisley,Darleen Sandoval
Stephanie Sisley
The central nervous system (CNS), generally accepted to regulate energy homeostasis, has been implicated in the metabolic perturbations that either cause or are associated with obesity. Normally, the CNS receives hormonal, metabolic, and ne...
Safety and efficacy of contraception--Why should the obese woman be any different? [0.03%]
避孕的安全性和有效性—为何肥胖女性会有所不同？
Maria I Rodriguez,Alison B Edelman
Maria I Rodriguez
The public health impact of obesity and unintended pregnancy is profound with far reaching consequences. Obese women are less likely to use contraception due to a variety of self-induced and systems-based barriers but their risk of becoming...
Location, location, location: genetic regulation of neural sex differences [0.03%]
位置，位置，位置：神经性别差异的遗传调节
Jean LeBeau Abel,Emilie F Rissman
Jean LeBeau Abel
Sex differences in many behaviors such as cognition, mood, and motor skills are well-documented in animals and humans and are regulated by many neural circuits. Sexual dimorphisms within cell populations in these circuits play critical role...
Julie A Markham
Julie A Markham
The peak in incidence for schizophrenia is during late adolescence for both sexes, but within this time frame the peak is both earlier and steeper for males. Additionally, women have a second peak in incidence following menopause. Two meta-...
Thomas G DeLoughery
Thomas G DeLoughery
Soon after the introduction of hormonal oral contraceptive agents reports of thrombotic complications appeared. In the past several decades, large epidemiological studies helped defined these risks for both arterial and venous complications...
Why family planning matters [0.03%]
计划生育为何重要
Jeffrey T Jensen
Jeffrey T Jensen
Family planning is one of the principle tools of human development. Ensuring that all babies are wanted and planned reduces health care and social costs. Human numbers will increase to 11 billion by the end of this century, and human activi...
Michelle M Isley,Andrew M Kaunitz
Michelle M Isley
Combination hormonal contraception and progestin-only contraception (including depot medroxyprogesterone acetate [DMPA]) are effective and convenient forms of reversible contraception that millions of women use worldwide. In recent years, o...