Heike A Bischoff-Ferrari
Heike A Bischoff-Ferrari
This review will summarize the impact of vitamin D deficiency on muscle health. Mechanistic evidence regarding the presence of the specific vitamin D receptor in muscle tissue and muscle biopsy abnormalities observed with deficiency will be...
The role of vitamin D in the FGF23, klotho, and phosphate bone-kidney endocrine axis [0.03%]
维生素D在FGF23、老化蛋白和磷的骨-肾内分泌轴中的作用
Mark R Haussler,G Kerr Whitfield,Ichiro Kaneko et al.
Mark R Haussler et al.
1,25-dihydroxyvitamin D (1,25D), through association with the nuclear vitamin D receptor (VDR), exerts control over a novel endocrine axis consisting of the bone-derived hormone FGF23, and the kidney-expressed klotho, CYP27B1, and CYP24A1 g...
Effects of polymorphisms in gonadotropin and gonadotropin receptor genes on reproductive function [0.03%]
促性腺激素及其受体基因多态性对生殖功能的影响
Livio Casarini,Elisa Pignatti,Manuela Simoni
Livio Casarini
Gonadotropins, the action of which is mediated at the level of their gonadal receptors, play a key role in sexual development, reproductive functions and in metabolism. The involvement of the gonadotropins and their receptor genotypes on re...
Regulation of target gene expression by the vitamin D receptor - an update on mechanisms [0.03%]
维生素D受体调节靶基因表达的机制研究进展
J Wesley Pike,Mark B Meyer,Kathleen A Bishop
J Wesley Pike
Virtually all of the known biological actions of the hormonal ligand 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) are mediated by the vitamin D receptor (VDR). Following binding and activation by the ligand, the VDR localizes in the nucleus...
Mechanism of action of vitamin D and the vitamin D receptor in colorectal cancer prevention and treatment [0.03%]
维生素D和维甲酸D受体在结直肠癌预防与治疗中的作用机制研究
Stephen W Byers,Tracey Rowlands,Marcy Beildeck et al.
Stephen W Byers et al.
Vitamin D and its analogs are potent inhibitors of colorectal cancer growth and metastasis. A number of recent studies have defined the intersections between the β-catenin-TCF pathway (a known contributor to colorectal cancer progression) ...
Mechanism of action of 1,25-dihydroxyvitamin D3 on intestinal calcium absorption [0.03%]
1，25-二羟基维生素D3促进钙吸收的机制研究
Sylvia Christakos
Sylvia Christakos
1,25-Dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) is the major controlling hormone of intestinal calcium absorption. As the body's demand for calcium increases from a diet deficient in calcium, from growth, pregnancy or lactation, the synthesis ...
Prajna Banerjee,Asgerally T Fazleabas
Prajna Banerjee
The primary embryonic signal in primates is chorionic gonadotropin (CG, designated hCG in humans), that is classically associated with corpus luteum rescue and progesterone production. However, research over the past decade has revealed the...
Daniel D Bikle
Daniel D Bikle
The keratinocytes of the skin are unique in being not only the primary source of vitamin D for the body, but in possessing both the enzymatic machinery to metabolize the vitamin D produced to active metabolites (in particular 1,25(OH)(2)D) ...
John H White
John H White
Vitamin D has emerged as a pleiotropic regulator of human physiology, and recent work has revealed that it has several roles in control of human immune system function. Vitamin D was originally characterized for its role in calcium homeosta...
Synthesis and secretion of gonadotropins including structure-function correlates [0.03%]
促性腺激素的合成与分泌（包括结构功能关系）
George R Bousfield,James A Dias
George R Bousfield
The synthesis and secretion of the gonadotropic hormones involves coordination of signal transduction, gene expression, protein translation, post-translational folding and modification and finally secretion. The production of biologically a...