Joseph Nuñez
Joseph Nuñez
Brain injury during development can have severe, long-term consequences. Using an array of animal models, we have an understanding of the etiology of perinatal brain injury. However, we have only recently begun to address the consequences o...
Vandana Jain,Vinod Kumar Paul
Vandana Jain
Maternal micronutrient restriction programs the body adiposity, adipocyte function and lipid metabolism in offspring: a review [0.03%]
母体微量营养素限制可编程后代体脂率、脂肪细胞功能和脂质代谢：综述
K Rajender Rao,I J N Padmavathi,M Raghunath
K Rajender Rao
Fetal growth is a complex process which depends both on the genetic makeup and intrauterine environment. Maternal nutrition during pregnancy is an important determinant of fetal growth. Adequate nutrient supply is required during pregnancy ...
Malgorzata S Martin-Gronert,Susan E Ozanne
Malgorzata S Martin-Gronert
It is well established that there is a relationship between patterns of early growth and subsequent risk of development of metabolic diseases such as type 2 diabetes and cardiovascular disease. Studies in both humans and in animal models ha...
Satish C Kalhan,Susan E Marczewski
Satish C Kalhan
Methionine and folate are the key components of one carbon metabolism, providing the methyl groups for numerous methyl transferase reactions via the ubiquitous methyl donor, s-adenosyl methionine. Methionine metabolism is responsive to nutr...
Body composition in infants: evidence for developmental programming and techniques for measurement [0.03%]
婴儿体成分：发育程序的证据及测量技术
Jonathan C K Wells
Jonathan C K Wells
The consequences of fetal growth retardation remain unclear, in part because they appear to vary between industrialized and developing countries. Data on body composition offer a new opportunity to investigate this issue, and may be of part...
Catch up growth in low birth weight infants: striking a healthy balance [0.03%]
低出生体重儿的追赶性生长：寻求健康平衡点
Vandana Jain,Atul Singhal
Vandana Jain
Catch-up growth in the first few months of life is seen almost ubiquitously in infants born small for their gestational age and conventionally considered highly desirable as it erases the growth deficit. However, recently such growth has be...
Chittaranjan Sakerlal Yajnik,Urmila Shailesh Deshmukh
Chittaranjan Sakerlal Yajnik
India is world's capital for low birth weight (LBW), which is ascribed to intrauterine growth restriction (IUGR) rather than prematurity. An average Indian mother is short and thin and gives birth to a light and thin baby. Maternal undernut...
Mechanisms affecting neuroendocrine and epigenetic regulation of body weight and onset of puberty: potential implications in the child born small for gestational age (SGA) [0.03%]
影响神经内分泌和表观遗传体重调节及青春期发动的机制：小胎龄儿（SGA）中的潜在意义
Christian L Roth,Sheela Sathyanarayana
Christian L Roth
Signaling peptides produced in peripheral tissues such as gut, adipose tissue, and pancreas communicate with brain centers, such as hypothalamus and hindbrain to manage energy homeostasis. These regulatory mechanisms of energy intake and st...
Ken Ichi Matsuda,Hiroko Mori,Mitsuhiro Kawata
Ken Ichi Matsuda
Sexual differentiation of the brain can be considered as a process during which effects of sex steroid hormones secreted during early development is maintained into adulthood. Epigenetic regulation is emerging as a potentially important mec...