Bonggi Lee,Jianhua Shao
Bonggi Lee
White adipose tissue (WAT) is the premier energy depot. Since the discovery of the hormonal properties of adipose-secreted proteins such as leptin and adiponectin, WAT has been classified as an endocrine organ. Although many regulatory effe...
Disruption of neurogenesis by hypothalamic inflammation in obesity or aging [0.03%]
肥胖或衰老时下丘脑炎症对神经发生的干扰
Sudarshana Purkayastha,Dongsheng Cai
Sudarshana Purkayastha
Adult neural stem cells contribute to neurogenesis and plasticity of the brain which is essential for central regulation of systemic homeostasis. Damage to these homeostatic components, depending on locations in the brain, poses threat to i...
Dongsheng Cai
Dongsheng Cai
Control of body weight versus tumorigenesis by concerted action of leptin and estrogen [0.03%]
瘦素和雌激素在体重控制和抑癌中的协同作用
Zhao He,Gen-Sheng Feng
Zhao He
Improper body weight control is most critical to the development of morbid obesity, which is often associated with alternation in leptin (Ob) signaling in the central nervous system. Leptin acts to control fat mass through the regulation of...
A proteolytic pathway that controls glucose uptake in fat and muscle [0.03%]
一条调控脂肪和肌肉葡萄糖吸收的蛋白水解信号途径
Jonathan P Belman,Estifanos N Habtemichael,Jonathan S Bogan
Jonathan P Belman
Insulin regulates glucose uptake by controlling the subcellular location of GLUT4 glucose transporters. GLUT4 is sequestered within fat and muscle cells during low-insulin states, and is translocated to the cell surface upon insulin stimula...
The physiological roles of apolipoprotein J/clusterin in metabolic and cardiovascular diseases [0.03%]
载脂蛋白J/簇素在代谢和心血管疾病中的生理作用
S Park,K W Mathis,I K Lee
S Park
Several isoforms of apolipoprotein J/clusterin (CLU) are encoded from a single gene located on chromosome 8 in humans. These isoforms are ubiquitously expressed in the tissues, and have been implicated in aging, neurodegenerative disorders,...
Autophagy as a crosstalk mediator of metabolic organs in regulation of energy metabolism [0.03%]
自噬作为代谢器官之间交叉对话的介质调节能量代谢
Kook Hwan Kim,Myung-Shik Lee
Kook Hwan Kim
Autophagy plays an important role in the regulation of cellular homeostasis through elimination of aggregated proteins, damaged organelles, and intracellular pathogens. Autophagy also contributes to the maintenance of energy balance through...
James E Blevins,Jacqueline M Ho
James E Blevins
Obesity and its associated metabolic disorders are growing health concerns in the US and worldwide. In the US alone, more than two-thirds of the adult population is classified as either overweight or obese [1], highlighting the need to deve...
Glenn C Rowe,Zoltan Arany
Glenn C Rowe
Type II diabetes and its complications are a tremendous health burden throughout the world. Our understanding of the changes that lead to glucose imbalance and insulin resistance and ultimately diabetes remain incompletely understood. Many ...
Muhammad Issa Khan,Faqir Muhammad Anjum,Muhammad Sohaib et al.
Muhammad Issa Khan et al.
The metabolic syndrome is one of the most vibrant and widely prevailing health concerns worldwide. It is characterized by several metabolic abnormalities, which involve obesity, insulin resistance, dyslipidemia, enhanced oxidative stress; h...