Impact of glucagon-like peptide-1 on myocardial glucose metabolism revisited [0.03%]
GLP-1对心肌葡萄糖代谢的影响需重新评估
Jan Hansen,Birgitte Brock,Hans Erik Bøtker et al.
Jan Hansen et al.
The gut hormone glucagon-like peptide-1 (GLP-1) is an insulinotropic incretin with significant cardiovascular impact. Two classes of medication, GLP-1 analogues and DPP-4 inhibitors, have been developed that circumvent the rapid degradation...
Adam G Goodwill,Kieren J Mather,Abass M Conteh et al.
Adam G Goodwill et al.
Glucagon-like peptide-1 (GLP-1) is an incretin hormone that has been shown to have hemodynamic and cardioprotective capacity in addition to its better characterized glucoregulatory actions. Because of this, emerging research has focused on ...
Meera Shah,Adrian Vella
Meera Shah
Glucagon-like peptide 1 (GLP-1) is a cleavage product of the pre-proglucagon gene which is expressed in the α-cells of the pancreas, the L-cells of the intestine, and neurons located in the caudal brainstem and hypothalamus. GLP-1 is of re...
Jeppe Skov
Jeppe Skov
The incretin hormone, glucagon-like peptide-1 (GLP-1), stimulates insulin secretion and forms the basis of a new drug class for diabetes treatment. GLP-1 has several extra-pancreatic properties which include effects on kidney function. Alth...
Gut microbiota and GLP-1 [0.03%]
肠道菌群和GLP-1
Amandine Everard,Patrice D Cani
Amandine Everard
A large body of evidence suggests that the regulation of energy balance and glucose homeostasis by fermentable carbohydrates induces specific changes in the gut microbiota. Among the mechanisms, our research group and others have demonstrat...
GLP-1R activation for the treatment of stroke: updating and future perspectives [0.03%]
GLP-1受体激活在卒中治疗中的作用:现状与未来展望
Vladimer Darsalia,David Nathanson,Thomas Nyström et al.
Vladimer Darsalia et al.
Stroke is the leading cause of adult disability in Westernized societies with increased incidence along ageing and it represents a major health and economical threat. Inactive lifestyle, smoking, hypertension, atherosclerosis, obesity and d...
Terry P Combs,Errol B Marliss
Terry P Combs
High glucose production contributes to fed and fasted hyperglycemia in Type 1 Diabetes (T1D) and Type 2 Diabetes (T2D). The breakdown of the adiponectin signaling pathway in T1D and the reduction of circulating adiponectin in T2D contribute...
Role of protein tyrosine phosphatases in the modulation of insulin signaling and their implication in the pathogenesis of obesity-linked insulin resistance [0.03%]
蛋白酪氨酸磷酸酶在胰岛素信号转导中的作用及其对肥胖相关胰岛素抵抗发病机制的影响
Elaine Xu,Michael Schwab,André Marette
Elaine Xu
Insulin resistance is a major disorder that links obesity to type 2 diabetes mellitus (T2D). It involves defects in the insulin actions owing to a reduced ability of insulin to trigger key signaling pathways in major metabolic tissues. The ...
Nam Ho Jeoung,Chris R Harris,Robert A Harris
Nam Ho Jeoung
Pyruvate is an obligatory intermediate in the oxidative disposal of glucose and a major precursor for the synthesis of glucose, glycerol, fatty acids, and non-essential amino acids. Stringent control of the fate of pyruvate is critically im...
Maria Paula Macedo,Inês S Lima,Joana M Gaspar et al.
Maria Paula Macedo et al.
Ingestion of a meal is the greatest challenge faced by glucose homeostasis. The surge of nutrients has to be disposed quickly, as high concentrations in the bloodstream may have pathophysiological effects, and also properly, as misplaced re...