The development of growth hormone-releasing hormone analogs: Therapeutic advances in cancer, regenerative medicine, and metabolic disorders [0.03%]
生长激素释放激素类似物的发展：癌症、再生医学和代谢疾病的治疗进展
Andrew V Schally,Renzhi Cai,Xianyang Zhang et al.
Andrew V Schally et al.
Growth Hormone-Releasing Hormone (GHRH) and its analogs have gained significant attention for their therapeutic potential across various domains, including oncology, regenerative medicine, and metabolic disorders. Originally recognized for ...
Central and peripheral regulation of the GH/IGF-1 axis: GHRH and beyond [0.03%]
生长激素/胰岛素样生长因子-1轴的中枢和外周调节：促生长激素释放激素及其他因素
Fabio Bioletto,Emanuele Varaldo,Valentina Gasco et al.
Fabio Bioletto et al.
The regulation of growth hormone (GH) synthesis and secretion by somatotroph cells of the anterior pituitary is a highly complex process, mediated by a variety of neuroendocrine and peripheral influences. In particular, a key role is played...
Hong Yu,Huan Peng
Hong Yu
Growth hormone-releasing hormone (GHRH) is a crucial endocrine hormone that exerts its biological effects by binding to specific receptors on the cell surface, known as GHRH receptors (GHRH-R). This binding activates downstream signaling pa...
Charlotte Steenblock,Stefan R Bornstein
Charlotte Steenblock
Despite over a century of insulin therapy and recent advances in glucose monitoring, diabetes and its complications remain a significant burden. Current medications are not durable, with symptoms often returning after treatment ends, and re...
Reference intervals for serum prolactin concentrations: analytical and clinical considerations [0.03%]
血清泌乳素浓度的参考区间：分析和临床考量
Kate Coleman,Mohamed Saleem
Kate Coleman
Prolactin is a 23 kDa protein synthesised and released by lactotrophs located in the anterior pituitary gland. The main function of prolactin is the development of the mammary glands and the production and maintenance of milk secretion duri...
Meal replacement therapy for obesity and diabetes remission: efficacy assessment and considerations of barriers and facilitators to adherence among U.S. individuals with low economic resources [0.03%]
代餐治疗肥胖和糖尿病缓解：美国低收入人群的有效性评估及坚持障碍和促进因素的考虑
Claudia G Durbin,Ainsley Hutchison,Talia Colecchi et al.
Claudia G Durbin et al.
Individuals in the United States with lower economic resources face a disproportionate burden of obesity and co-morbid conditions. This review summarizes the efficacy of MR programs for the treatment of obesity and diabetes and alerts clini...
Real-world evidence of effectiveness and safety of pasireotide in the treatment of acromegaly: a systematic review and meta-analysis [0.03%]
帕瑞肽治疗肢端肥大症有效性和安全性的真实世界证据的系统评价和 meta 分析
Betina Biagetti,Marta Araujo-Castro,Cristian Tebe et al.
Betina Biagetti et al.
Pasireotide long-acting release (PAS-LAR) is a second-generation somatostatin receptor ligand (SRL) approved for acromegaly treatment. This meta-analysis aimed to evaluate the real-world effectiveness and safety of PAS-LAR in patients with ...
GHRH and the prostate [0.03%]
生长激素释放素与前列腺的关系
Laura Muñoz-Moreno,Irene D Román,Ana M Bajo
Laura Muñoz-Moreno
In the late 1960s and early 1970s, hypothalamic regulatory hormones were isolated, characterized and sequenced. Later, it was demonstrated hypothalamic and ectopic production of growth hormone-releasing hormone (GHRH) in normal and tumor ti...
Anuradha Mishra,Deepak Modi
Anuradha Mishra
HOXA10 belongs to the homeobox gene family and is essential for uterine biogenesis, endometrial receptivity, embryo implantation, and stromal cell decidualization. Available evidence suggests that the expression of HOXA10 is dysregulated in...
Fahrettin Kelestimur,Adriana G Ioachimescu
Fahrettin Kelestimur
This special issue of Reviews in Endocrine and Metabolic Disorders is dedicated to hypoprolactinemia. Prolactin is known for its actions on the mammary gland including development, preparation for postpartum lactation, as well as synthesis ...