Rui Cheng,Jian-xing Ma
Rui Cheng
The prevalence of diabetes mellitus and obesity continues to increase globally. Diabetic vascular complications are the main chronic diabetic complications and associated with mortality and disability. Angiogenesis is a key pathological cha...
The role of gut microbiota in the development of type 1, type 2 diabetes mellitus and obesity [0.03%]
肠道菌群在1型、2型糖尿病及肥胖发病机制中的作用
Ningwen Tai,F Susan Wong,Li Wen
Ningwen Tai
Diabetes is a group of metabolic disorders characterized by persistent hyperglycemia and has become a major public health concern. Autoimmune type 1 diabetes (T1D) and insulin resistant type 2 diabetes (T2D) are the two main types. A combin...
Jianwen Wei,Gerard Karsenty
Jianwen Wei
A recent unexpected development of bone biology is that bone is an endocrine organ contributing to the regulation of a number of physiological processes. One of the functions regulated by bone through osteocalcin, an osteoblast specific hor...
T John Martin,Natalie A Sims
T John Martin
After it was proposed that the osteoblast lineage controlled the formation of osteoclasts, cell culture methods were developed that established this to be the case. Evidence was obtained that cytokines and hormones that promote osteoclast f...
The update of anthocyanins on obesity and type 2 diabetes: experimental evidence and clinical perspectives [0.03%]
花青素对肥胖和二型糖尿病的影响：实验数据及临床意义
Honghui Guo,Wenhua Ling
Honghui Guo
With the dramatically increasing prevalence of obesity and type 2 diabetes mellitus (T2DM) worldwide, there is an urgent need for new strategies to combat the growing epidemic of these metabolic diseases. Diet is an essential factor affecti...
The role of the Nrf2/Keap1 pathway in obesity and metabolic syndrome [0.03%]
Nrf2/Keap1信号通路在肥胖和代谢综合征中的作用
Zhiguo Zhang,Shanshan Zhou,Xin Jiang et al.
Zhiguo Zhang et al.
Nuclear factor erythroid 2 related factor 2 (Nrf2) is a key regulator of antioxidant signaling that may prevent the development of metabolic syndrome and related cardiovascular diseases. However, emerging evidence shows that lack of Nrf2 co...
Regulation of energy balance by inflammation: common theme in physiology and pathology [0.03%]
炎症介导的能量平衡调节：生理与病理的共同主题
Hui Wang,Jianping Ye
Hui Wang
Inflammation regulates energy metabolism in both physiological and pathological conditions. Pro-inflammatory cytokines involves in energy regulation in several conditions, such as obesity, aging (calorie restriction), sports (exercise), and...
Xinhui Wang,Xuexian Fang,Fudi Wang
Xinhui Wang
As an essential element, iron plays a central role in many physiological processes, including redox balance, inflammation, energy metabolism, and environment sensing. Perturbations in iron homeostasis are associated with several conditions,...
Dileep Unnikrishnan,Jonathan Jun,Vsevolod Polotsky
Dileep Unnikrishnan
Obstructive sleep apnea (OSA) is a common disorder associated with cardiovascular disease (CVD). One theory to explain this relationship proposes that OSA can induce systemic inflammation, thereby inducing CVD. This theory is based on the p...
Metabolic syndrome and the environmental pollutants from mitochondrial perspectives [0.03%]
从线粒体角度论代谢综合征与环境污染物的关系
Jin Taek Kim,Hong Kyu Lee
Jin Taek Kim
The worldwide epidemic of diabetes and metabolic syndrome in the last few decades cannot be fully accounted for only by changes in the lifestyle factors, such as sedentary lifestyle and overeating. Besides genetic factors, there must be oth...