Doping with anabolic androgenic steroids (AAS): Adverse effects on non-reproductive organs and functions [0.03%]
使用合成代谢雄性激素类固醇（AAS）的不良反应对其它非生殖系统和功能的影响
Eberhard Nieschlag,Elena Vorona
Eberhard Nieschlag
Since the 1970s anabolic androgenic steroids (AAS) have been abused at ever increasing rates in competitive athletics, in recreational sports and in bodybuilding. Exceedingly high doses are often consumed over long periods, in particular by...
Adverse effects of 5α-reductase inhibitors: What do we know, don't know, and need to know? [0.03%]
5α-还原酶抑制剂的不良反应：我们了解多少，尚不了解多少以及需要了解多少？
Abdulmaged M Traish,Roberto Cosimo Melcangi,Marco Bortolato et al.
Abdulmaged M Traish et al.
Steroids are important physiological orchestrators of endocrine as well as peripheral and central nervous system functions. One of the key processes for regulation of these molecules lies in their enzymatic processing by a family of 5α-red...
Jenny E Blau,Michael T Collins
Jenny E Blau
Fibroblast growth factor 23 (FGF23) has emerged as an important regulator of phosphate and vitamin D homeostasis. It is important to understand how FGF23 interacts with vitamin D and parathyroid hormone (PTH) in a FGF23-Vitamin D-PTH axis t...
The dynamic skeleton [0.03%]
动态骨骼系统
Anda Gonciulea,Suzanne Jan de Beur
Anda Gonciulea
Adding to its well-known roles in locomotion and calcium balance, the skeleton has recently been appreciated as a true endocrine organ. Bone remodeling, a highly dynamic process, requires synchronized activities and crosstalk between bone c...
Bone kidney interactions [0.03%]
骨肾相互作用
Thomas L Nickolas,Sophie A Jamal
Thomas L Nickolas
The fact that bone disease and kidney disease co-exist is well known. Formally, this inter-relationship is called chronic kidney disease mineral bone disorder or CKD-MBD. Traditionally, it was thought that bone played a passive role in CKD-...
Bone as a classic endocrine organ: Interactions with non-bone tissues [0.03%]
骨骼作为经典的内分泌器官：与非骨组织的相互作用
Elizabeth A Streeten
Elizabeth A Streeten
N Lara-Castillo,M L Johnson
N Lara-Castillo
A dozen years ago the identification of causal mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) gene involved in two rare bone disorders propelled research in the bone field in totally new directions. Since then, t...
Zhousheng Xiao,Leigh Darryl Quarles
Zhousheng Xiao
Skeletal loading is an important physiological regulator of bone mass. Theoretically, mechanical forces or administration of drugs that activate bone mechanosensors would be a novel treatment for osteoporotic disorders, particularly age-rel...
Bone, brain & beyond [0.03%]
骨骼、大脑及更广阔的研究领域
Alexandre Chamouni,Christiane Schreiweis,Franck Oury
Alexandre Chamouni
In the past 15 years, the field of physiology has been radically challenged by landmark studies using novel tools of genetic engineering. Particular to our interest, the reciprocal interactions between the skeleton and the nervous system we...
Maryam Sharifi,Lisa Ereifej,E Michael Lewiecki
Maryam Sharifi
Sclerostin is a cysteine-knot glycoprotein product of the SOST gene, predominately expressed by osteocytes, that is a regulator of osteoblastic bone formation. When sclerostin binds to its low-density lipoprotein receptor-related proteins 5...