Targeting the vitamin D endocrine system (VDES) for the management of inflammatory and malignant skin diseases: An historical view and outlook [0.03%]
靶向维生素D内分泌系统(VDES)以治疗炎症性和恶性皮肤病：历史回顾与未来展望
Jörg Reichrath,Christos C Zouboulis,Thomas Vogt et al.
Jörg Reichrath et al.
Vitamin D represents one of the major driving factors for the development of life on earth and for human evolution. While up to 10-20 % of the human organism's requirements in vitamin D can be obtained by the diet (under most living conditi...
E Makrantonaki,D Jiang,A M Hossini et al.
E Makrantonaki et al.
Diabetes is a debilitating, life-threatening disease accounting in 2015 for the death of 5 million people worldwide. According to new estimations, 415 million adults currently suffer from the disease, and this number is expected to rise to ...
Nutrition and skin [0.03%]
营养与皮肤
Apostolos Pappas,Aikaterini Liakou,Christos C Zouboulis
Apostolos Pappas
Nutrition has long been associated with skin health, including all of its possible aspects from beauty to its integrity and even the aging process. Multiple pathways within skin biology are associated with the onset and clinical course of v...
Artificial sweeteners and metabolic dysregulation: Lessons learned from agriculture and the laboratory [0.03%]
代糖与代谢紊乱：来自农业和实验室的启示
Jane Shearer,Susan E Swithers
Jane Shearer
Escalating rates of obesity and public health messages to reduce excessive sugar intake have fuelled the consumption of artificial sweeteners in a wide range of products from breakfast cereals to snack foods and beverages. Artificial sweete...
Alex Alexopoulos,George P Chrousos
Alex Alexopoulos
Emerging research has suggested that the skin is not only a target of organismal distress but also an active participant of the stress response through production of local "HPA axis" components, peripheral nerve endings, and resident skin c...
Qiang Ju,Christos C Zouboulis
Qiang Ju
Endocrine-disrupting chemicals (EDCs) are exogenous compounds that have the ability to disrupt the production and actions of hormones through direct or indirect interaction with hormone receptors, thus acting as agonists or antagonists. Hum...
M Badawy Abdel-Naser,Christos C Zouboulis
M Badawy Abdel-Naser
Male fertility can be affected by a variety of organs diseases, including the skin. Several genodermatoses affect the skin and several other organs including the male reproductive system, commonly in the form of cryptorchidism and hypogonad...
Theoharis C Theoharides,Julia M Stewart,Alexandra Taracanova et al.
Theoharis C Theoharides et al.
The skin is considered the mirror of the soul and is affected by neurohormonal triggers, especially stress. Hair follicles, keratinocytes, mast cells, melanocytes, and sebocytes all express sex and stress hormones implicating them in a loca...
Salvatore Benvenga,Alessandro Antonelli
Salvatore Benvenga
Myo-inositol and phosphatidylinositol(s) play a pivotal function in many metabolic pathways that, if impaired, impact unfavorably on human health. This review analyzes several experimental and clinical investigations regarding the involveme...
Salvatore Benvenga,Fabrizio Guarneri
Salvatore Benvenga
Hypothesized 40 years ago, molecular mimicry has been thereafter demonstrated as an extremely common mechanism by which microbes elude immune response and modulate biosynthetic/metabolic pathways of the host. In genetically predisposed pers...