Borja Bandera-Merchan,Hatim Boughanem,Ana B Crujeiras et al.
Borja Bandera-Merchan et al.
Epigenetic alterations in cancer play a variety of roles. Aberrant DNA methylation, as one of the epigenetic mechanisms, has been widely studied in both tumor and liquid biopsies and provide a useful bench mark for treatment response in can...
Are aggressive pituitary tumors and carcinomas two sides of the same coin? Pathologists reply to clinician's questions [0.03%]
积极型垂体肿瘤和癌是同一枚硬币的正反面吗？病理学家对临床医生问题的回答
Jacqueline Trouillas,Marie-Lise Jaffrain-Rea,Alexandre Vasiljevic et al.
Jacqueline Trouillas et al.
Pituitary adenohypophyseal tumors are considered as benign and termed "adenomas". However, many tumors are invasive and a proportion of these exhibit an "aggressive behavior" with premature death due to progressive growth. Only very rare (0...
Surgical treatment of aggressive pituitary adenomas and pituitary carcinomas [0.03%]
侵袭性垂体腺瘤和垂体癌的手术治疗
Michael Buchfelder,Sven-Martin Schlaffer
Michael Buchfelder
Surgery of aggressive pituitary adenomas and pituitary carcinomas is part of the interdisciplinary management of these difficult to treat tumors. Invasion, giant size and unusual, asymmetric extent of these tumors frequently require modific...
The use of Broca index to assess cut- off points for overweight in adults: A short review [0.03%]
Broca指数在成人超重判断中切点选择的简要综述
Irakoze Laurent,Manirakiza Astère,Banderembako Paul et al.
Irakoze Laurent et al.
The Broca formula was developed in 1871 by Pierre Paul Broca (a French Army Doctor) to help establish ideal body weight or normal body weight. Initially, the Broca Index (BI) was used to work out the normal weight but was later expanded to ...
Theranostics in neuroendocrine tumors: an overview of current approaches and future challenges [0.03%]
神经内分泌肿瘤诊疗现状及未来展望
Julie Refardt,Johannes Hofland,Antwi Kwadwo et al.
Julie Refardt et al.
Neuroendocrine neoplasms (NENs) comprise a heterogeneous group of tumors, mainly localized in the gastrointestinal system. What characterizes NENs is the expression of hormone receptors on the tumor cell surface, making them accessible for ...
The optimal numerosity of the referral population of pituitary tumors centers of excellence (PTCOE): A surgical perspective [0.03%]
垂体肿瘤卓越治疗中心（PTCOE）的转诊患者最优数量：外科医生的视角
Pietro Mortini,Gianluca Nocera,Francesca Roncelli et al.
Pietro Mortini et al.
Surgical experience is of paramount importance to reach therapeutic success and minimize operative complications. In the field of pituitary surgery, this led to the concept of Pituitary Center of Excellence (PTCOE) defined as a center where...
The journey in diagnosis and treatment, from pituitary adenoma to aggressive pituitary tumors [0.03%]
垂体腺瘤到侵袭性垂体肿瘤的诊断和治疗之路
Maria Fleseriu,Vera Popovic
Maria Fleseriu
Thalijn L C Wolters,Mihai G Netea,Niels P Riksen et al.
Thalijn L C Wolters et al.
Acromegaly is characterized by Growth Hormone (GH) and Insulin-like Growth Factor 1 (IGF-1) excess. Uncontrolled acromegaly is associated with a strongly increased risk of cardiovascular disease (CVD), and numerous cardiovascular risk facto...
Kelvin Tran,Peter Reaven
Kelvin Tran
Despite robust evidence linking long-term hyperglycemia with cardiovascular complications, several large randomized trials found only modest benefits from intensive compared to standard glucose control. Of these trials, the Veteran Affairs ...
Regulation of energy intake and mechanisms of metabolic adaptation or maladaptation after caloric restriction [0.03%]
能量摄入的调节以及在节食后的代谢适应或不适应机制
Roberto Vettor,Angelo Di Vincenzo,Pietro Maffei et al.
Roberto Vettor et al.
Despite their critical role in susceptibility to metabolic diseases such as obesity and type 2 diabetes, mechanisms regulating energy balance are extremely complex and far from being fully understood. Both central and peripheral feedback ci...