In search of an ideal drug for safer treatment of obesity: The false promise of pseudoephedrine [0.03%]
寻找理想的肥胖症治疗药物：伪麻黄碱的虚假承诺
Antonio Munafò,Stefano Frara,Norberto Perico et al.
Antonio Munafò et al.
Obesity is a major public health problem worldwide. Only relatively few treatment options are, at present, available for the management of obese patients. Furthermore, treatment of obesity is affected by the widespread misuse of drugs and f...
Physical activity and adipokine levels in individuals with type 2 diabetes: A literature review and practical applications [0.03%]
运动对2型糖尿病患者脂联素水平的影响：文献回顾与实践应用
Hassane Zouhal,Navabeh Zare-Kookandeh,Marjan Mosalman Haghighi et al.
Hassane Zouhal et al.
We review the effects of acute and long-term physical activity on adipokine levels in individuals with type 2 diabetes (T2D). Three electronic databases were searched. Studies made in animal models were excluded, while studies based on part...
Is constitutional thinness really different from anorexia nervosa? A systematic review and meta-analysis [0.03%]
宪法性消瘦与神经性厌食症真的不同吗？系统评价和meta分析
Mélina Bailly,Audrey Boscaro,Bruno Pereira et al.
Mélina Bailly et al.
A growing interest in constitutional thinness has been observed in the last decades, but the publications however cover various fields of study and report equivocal results. The present work systematically reviewed any clinical trials enrol...
AKT ISOFORMS-AS160-GLUT4: The defining axis of insulin resistance [0.03%]
Akt 同工酶-As160-葡萄糖转运蛋白4(GLUT4)轴在胰岛素抵抗中的作用
Medha Sharma,Chinmoy Sankar Dey
Medha Sharma
The Akt isoforms-AS160-GLUT4 axis is the primary axis that governs glucose homeostasis in the body. The first step on the path to insulin resistance is deregulated Akt isoforms. This could be Akt isoform expression, its phosphorylation, or ...
Are recist criteria adequate in assessing the response to therapy in metastatic NEN? [0.03%]
RECIST评估标准能否有效评价转移性神经内分泌肿瘤疗效？
Marie-Pierre Vullierme,Philippe Ruszniewski,Louis de Mestier
Marie-Pierre Vullierme
Response to therapy criteria, known as RECIST (Response Evaluation Criteria in Solid Tumours), are widely used to evaluate neuroendocrine tumours (NET) metastatic to the liver, under treatment. RECIST criteria does not take in account many ...
Aging versus youth: Endocrine aspects of vulnerability for COVID-19 [0.03%]
衰老与年轻：脆弱性COVID-19的内分泌学方面
Seda Hanife Oguz,Meltem Koca,Bulent Okan Yildiz
Seda Hanife Oguz
Coronavirus Disease 2019 (COVID-19) is characterized with a wide range of clinical presentations from asymptomatic to severe disease. In patients with severe disease, the main causes of mortality have been acute respiratory distress syndrom...
Impact of exercise training after bariatric surgery on cardiometabolic risk factors: a systematic review and meta-analysis of controlled trials [0.03%]
代谢手术后运动训练对心代谢危险因素影响的系统评价和.meta.分析
Alejandro Carretero-Ruiz,Elena Martínez-Rosales,Iván Cavero-Redondo et al.
Alejandro Carretero-Ruiz et al.
The purpose of this systematic review was to provide updated evidence synthesis of the effectiveness of exercise training in patients with obesity undergoing bariatric surgery to improve cardio-metabolic risk. We systematically searched the...
The impact of hypoxia exposure on glucose homeostasis in metabolically compromised humans: A systematic review [0.03%]
缺氧暴露对代谢紊乱人群糖代谢影响的系统性综述
Veerle van Hulten,Rens L J van Meijel,Gijs H Goossens
Veerle van Hulten
Humans living at a higher altitude are less prone to suffer from impaired glucose homeostasis and type 2 diabetes mellitus (T2DM), which might at least partly be explained by lower oxygen availability at higher altitudes. The present system...
Manuela Albertelli,Andrea Dotto,Federica Nista et al.
Manuela Albertelli et al.
Immunotherapy, so promising in many neoplasms, still does not have a precise role in the treatment of neuroendocrine neoplasms (NENs). In this article, we provide an overview on the current knowledge about immunotherapy with immune checkpoi...
Hypocalcemia in COVID-19: Prevalence, clinical significance and therapeutic implications [0.03%]
新冠肺炎的低血钙：流行率、临床意义及治疗启示
Luigi di Filippo,Mauro Doga,Stefano Frara et al.
Luigi di Filippo et al.
COVID-19 extra-pulmonary features include several endocrine manifestations and these are becoming strongly clinically relevant in patients affected influencing disease severity and outcomes.At the beginning of COVID-19 pandemic no populatio...