Metabolic responses of light and taste receptors - unexpected actions of GPCRs in adipocytes [0.03%]
光和味受体的代谢反应-G蛋白偶联受体在脂肪细胞中的意外作用
Onyinye Nuella Ekechukwu,Mark Christian
Onyinye Nuella Ekechukwu
The G-protein-coupled receptor (GPCR) superfamily includes sensory receptors that can detect and respond to taste and light. Recent investigations have identified key metabolic roles for such receptors in tissues considered 'non-sensory' su...
Functional ACE2 deficiency leading to angiotensin imbalance in the pathophysiology of COVID-19 [0.03%]
功能性的ACE2缺乏导致新冠病毒病理生理过程中心血管紧张素失衡
Joshua R Cook,John Ausiello
Joshua R Cook
SARS-CoV-2, the virus responsible for COVID-19, uses angiotensin converting enzyme 2 (ACE2) as its primary cell-surface receptor. ACE2 is a key enzyme in the counter-regulatory pathway of the broader renin-angiotensin system (RAS) that has ...
Therapeutic potentials of agonist and antagonist of adenosine receptors in type 2 diabetes [0.03%]
腺苷受体激动剂与拮抗剂在2型糖尿病治疗中的潜力
Olakunle Sanni,G Terre&#x;Blanche
Olakunle Sanni
Type 2 diabetes has been a global health challenge over the decades and is among the leading causes of death. Several treatment approaches have been developed, but more effective and new therapies are still needed. The role of adenosine in ...
A systematic review of resting-state functional connectivity in obesity: Refining current neurobiological frameworks and methodological considerations moving forward [0.03%]
系统性综述肥胖症的静息态功能连接：当前神经生物学框架和未来的方法学考虑因素的完善
Nicholas Parsons,Trevor Steward,Rebecca Clohesy et al.
Nicholas Parsons et al.
Obesity is the second most common cause of preventable morbidity worldwide. Resting-state functional magnetic resonance imaging (fMRI) has been used extensively to characterise altered communication between brain regions in individuals with...
Extracellular vesicles-incorporated microRNA signature as biomarker and diagnosis of prediabetes state and its complications [0.03%]
基于细胞外囊泡包裹的微小核糖核酸标志物筛选及在糖尿病前期及其并发症诊断中的应用研究
Nicoleta Alexandru,Anastasia Procopciuc,Alexandra Vîlcu et al.
Nicoleta Alexandru et al.
Extracellular vesicles (EVs) are small anuclear vesicles, delimited by a lipid bilayer, released by almost all cell types, carrying functionally active biological molecules that can be transferred to the neighbouring or distant cells, induc...
Beta-klotho in type 2 diabetes mellitus: From pathophysiology to therapeutic strategies [0.03%]
2型糖尿病 mellitus中的 Beta-洛萨LOTA：从病理生理到治疗策略
Shuang Hua,Qianying Liu,Jufei Li et al.
Shuang Hua et al.
Type 2 diabetes mellitus (T2DM) has become a global health problem with no cure. Despite lifestyle modifications and various pharmaceutical options, the achievement of stable and durable glucose control along with effective prevention of T2...
The multifaceted progenitor fates in healthy or unhealthy adipose tissue during obesity [0.03%]
肥胖期间健康或不健康的脂肪组织中的多面谱系祖细胞命运
Geneviève Marcelin,Karine Clément
Geneviève Marcelin
While obesity is defined as an excessive fat accumulation conferring a risk to metabolic health, increased adipose mass by itself does not fully explain obesity's propensity to promote metabolic alterations. Adipose tissue regulates multipl...
Metabolic syndrome and male fertility disorders: Is there a causal link? [0.03%]
代谢综合征与男性生育障碍：是否存在因果关系？
Débora Juana Cohen,María Milagros Giaccagli,Jael Dafne Herzfeld et al.
Débora Juana Cohen et al.
Infertility is a global health problem affecting 10-15% of couples in reproductive age. Recent studies have provided growing evidence supporting that lifestyle factors can affect male fertility through alterations in endocrine profiles, spe...
Ectopic Cushing's syndrome due to thymic neuroendocrine tumours: a systematic review [0.03%]
起源于胸腺神经内分泌肿瘤的异位库欣综合征：系统性回顾
Fernando Guerrero-Pérez,Inmaculada Peiró,Agustina Pia Marengo et al.
Fernando Guerrero-Pérez et al.
Knowledge of ectopic Cushing's syndrome (CS) due to thymic neuroendocrine tumours (NETs) comes from short series or single cases. Our aim is to perform a systematic review using PubMed, Embase, Scopus, Ovid Medline and Biosis Previews of al...
Magdalena Stasiak,Andrzej Lewiński
Magdalena Stasiak
Subacute thyroiditis (SAT) is a thyroid inflammatory disease, whose pathogenesis and determinants of the clinical course were unclear for many decades. The last few years have brought many clinically significant new data on the epidemiology...