Daniel D Bikle
Daniel D Bikle
Covid-19 has to date infected a confirmed 275 million people with 5.4 million, now dead, with the count rising every day. Although the virus, SARS-CoV2, causing Covid-19 infects many cells in the body, its infection of the upper and lower r...
Emerging roles of Galectin-3 in diabetes and diabetes complications: A snapshot [0.03%]
岩藻糖结合凝集素-3在糖尿病及其并发症中的作用：概览
Yanhua Li,Tian Li,Zhiguang Zhou et al.
Yanhua Li et al.
Galectin-3 is a member of the galectin family, widely expressed in immune cells and plays a role mainly in inflammation, autoimmunity, apoptosis, and chemotaxis. We summarized the roles of Galectin-3 in diabetes and its complications, as we...
Pasireotide-a novel somatostatin receptor ligand after 20 years of use [0.03%]
帕瑞肽——somatostatin受体配体20年应用后的新型药物
Marek Bolanowski,Marcin Kałużny,Przemysław Witek et al.
Marek Bolanowski et al.
Pasireotide, a novel multireceptor-targeted somatostatin receptor ligand (SRL) is characterized by a higher affinity to somatostatin receptor type 5 than type 2, unlike first-generation SRLs. Because of the broader binding profile, pasireot...
Terry L Davidson,Richard J Stevenson
Terry L Davidson
Obesity, Type 2 diabetes and other metabolic disorders continue to pose serious challenges to human health and well-being. An important source of these challenges is the overconsumption of saturated fats and sugar, main staples of what has ...
A systematic review of multimodal clinical biomarkers in the management of thyroid eye disease [0.03%]
甲状腺相关性眼病的多模态临床生物标志物系统综述
Stephanie Hiu Ling Poon,Janice Jing-Chee Cheung,Kendrick Co Shih et al.
Stephanie Hiu Ling Poon et al.
Thyroid Eye Disease (TED) is an autoimmune disease that affects the extraocular muscles and periorbital fat. It most commonly occurs with Graves' Disease (GD) as an extrathyroidal manifestation, hence, it is also sometimes used interchangea...
Mechanisms linking obesity and its metabolic comorbidities with cerebral grey and white matter changes [0.03%]
肥胖及其代谢并发症与脑灰质和白质变化的关联机制
Isabel García-García,Andréanne Michaud,María Ángeles Jurado et al.
Isabel García-García et al.
Obesity is a preventable risk factor for cerebrovascular disorders and it is associated with cerebral grey and white matter changes. Specifically, individuals with obesity show diminished grey matter volume and thickness, which seems to be ...
The endocrine adipose organ [0.03%]
内分泌脂肪器官
Saverio Cinti
Saverio Cinti
The efficacy and safety of cinacalcet in primary hyperparathyroidism: a systematic review and meta-analysis of randomized controlled trials and cohort studies [0.03%]
西那卡塞治疗原发性甲状旁腺功能亢进症有效性和安全性的系统评价和meta分析
Manju Chandran,John P Bilezikian,Joel Lau et al.
Manju Chandran et al.
Cinacalcet, a positive allosteric modulator of the calcium sensing receptor (CaSR) reduces parathyroid hormone (PTH) secretion by increasing the sensitivity of the CaSR on parathyroid cells. We conducted a systematic review and meta-analysi...
Role of anatomical location, cellular phenotype and perfusion of adipose tissue in intermediary metabolism: A narrative review [0.03%]
解剖位置、细胞表型和脂肪组织灌注在中间代谢中的作用：叙事性综述
Stefania Camastra,Ele Ferrannini
Stefania Camastra
It is well-established that adipose tissue accumulation is associated with insulin resistance through multiple mechanisms. One major metabolic link is the classical Randle cycle: enhanced release of free fatty acids (FFA) from hydrolysis of...
Semaglutide, a glucagon like peptide-1 receptor agonist with cardiovascular benefits for management of type 2 diabetes [0.03%]
心血管方面有获益的GLP-1受体激动剂司美格鲁肽治疗2型糖尿病
Manoj Kumar Mahapatra,Muthukumar Karuppasamy,Biswa Mohan Sahoo
Manoj Kumar Mahapatra
Semaglutide, a glucagon like peptide-1 (GLP-1) receptor agonist, is available as monotherapy in both subcutaneous as well as oral dosage form (first approved oral GLP-1 receptor agonist). It has been approved as a second line treatment opti...