The uprise of RNA biology in neuroendocrine neoplasms: altered splicing and RNA species unveil translational opportunities [0.03%]
神经内分泌肿瘤中RNA生物学的兴起：异常剪接和RNA种类揭示了转化机会
Ricardo Blázquez-Encinas,María Trinidad Moreno-Montilla,Víctor García-Vioque et al.
Ricardo Blázquez-Encinas et al.
Neuroendocrine neoplasms (NENs) comprise a highly heterogeneous group of tumors arising from the diffuse neuroendocrine system. NENs mainly originate in gastrointestinal, pancreatic, and pulmonary tissues, and despite being rare, show risin...
The role of testosterone, the androgen receptor, and hypothalamic-pituitary-gonadal axis in depression in ageing Men [0.03%]
睾酮，雄激素受体以及下丘脑-垂体-性腺轴在老年男性抑郁症中的作用
Richard L Hauger,Ursula G Saelzler,Meghana S Pagadala et al.
Richard L Hauger et al.
Considerable research has shown that testosterone regulates many physiological systems, modulates clinical disorders, and contributes to health outcome. However, studies on the interaction of testosterone levels with depression and the anti...
Pregnancy in patients with adrenocortical carcinoma: a case-based discussion [0.03%]
肾上腺皮质癌患者怀孕一例及讨论
Soraya Puglisi,Vittoria Basile,Paola Sperone et al.
Soraya Puglisi et al.
Although adrenocortical carcinoma (ACC) during pregnancy is rare, a retrospective review of a case series at our hospital revealed that almost one third of our patients were women in childbearing age. Given that the age of maternity is incr...
The management of congenital adrenal hyperplasia during preconception, pregnancy, and postpartum [0.03%]
妊娠前后及产后先天性肾上腺皮质增生症的治疗
Jacqueline Yano Maher,Veronica Gomez-Lobo,Deborah P Merke
Jacqueline Yano Maher
Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders of steroidogenesis of the adrenal cortex, most commonly due to 21-hydroxylase deficiency caused by mutations in the CYP21A2 gene. Although women with CAH have ...
Extracellular-matrix mechanics regulate cellular metabolism: A ninja warrior behind mechano-chemo signaling crosstalk [0.03%]
细胞外基质力学调节细胞代谢：隐藏在机械化学信号交流背后的忍者勇士
Xiaoyu Liao,Xin Li,Rui Liu
Xiaoyu Liao
Mechanical forces are the indispensable constituent of environmental cues, such as gravity, barometric pressure, vibration, and contact with bodies, which are involved in pattern and organogenesis, providing mechanical input to tissues and ...
The anabolic applications of androgens in older adults with functional limitations [0.03%]
在有功能障碍的老年成年人中使用合成代谢类固醇的应用
Arijeet K Gattu,Anna L Goldman,Ezgi Caliskan Guzelce et al.
Arijeet K Gattu et al.
Aging is associated with a progressive decrease in skeletal muscle mass, strength and power and impairment of physical function. Serum testosterone concentrations in men decrease with advancing age due to defects at all levels of the hypoth...
Jean-Marc Kaufman
Jean-Marc Kaufman
To make the diagnosis of hypogonadism in an ageing man, in absence of rare organic cause often referred to as functional or late onset hypogonadism (LOH), he should present with a clinical syndrome suggestive of androgen deficiency and have...
Phase angle as an index of physiological status: validating bioelectrical assessments of hydration and cell mass in health and disease [0.03%]
相位角作为生理状态指标：在健康和疾病中验证生物电评估的水合状态和细胞质量
Henry C Lukaski,Antonio Talluri
Henry C Lukaski
Bioelectrical impedance (BI) is a practical method to assess body composition in health and disease. This method relies on the passive conduction of an applied, safe, low-level alternating current through water and electrolytes in the body....
Frederick Cw Wu,Ilpo T Huhtaniemi
Frederick Cw Wu
Patient and health care provider knowledge of diabetes and diabetic microvascular complications: a comprehensive literature review [0.03%]
糖尿病患者及医务人员对糖尿病及其微血管并发症的认知状况：全面文献回顾
Melissa A Elafros,Brian C Callaghan,Lesli E Skolarus et al.
Melissa A Elafros et al.
Diabetic retinopathy, neuropathy, and nephropathy occur in more than 50% of people with diabetes, contributing substantially to morbidity and mortality. Patient understanding of these microvascular complications is essential to ensure early...