Hyperphagia in rare melanocortin-4 receptor pathway diseases: therapeutic options and assessing treatment response [0.03%]
罕见黑素皮质素受体4通路疾病患者的摄食过量症状：治疗选择及疗效评估
Jesús Argente,Karine Clément,Jessica Duis et al.
Jesús Argente et al.
Hyperphagia is a hallmark of both congenital and acquired rare melanocortin-4 receptor (MC4R) pathway diseases. Currently, the medical community has no standard treatment guidelines or approach to establishing treatment benefit. This narrat...
Targeted therapeutic strategies as alternative and sustainable treatment options for obesity-induced steatohepatitis [0.03%]
肥胖诱导的steatohepatitis的治疗策略作为替代和可持续的治疗选项
Thendo I Mabuda,Nicole R S Sibuyi,Adewale O Fadaka et al.
Thendo I Mabuda et al.
BBSome: An essential component of hypothalamic regulation of energy homeostasis [0.03%]
BBSome：能量稳态的下丘脑调节的一个重要组成部分
Deng Fu Guo,Yuying Zhao,Connor Laule et al.
Deng Fu Guo et al.
The BBSome is a protein complex composed of eight Bardet-Biedl syndrome (BBS) proteins. Although the BBSome is best known for its role in regulating cilia function, accumulating evidence indicates that this protein complex is also involved ...
Sexual dimorphism in the development and function of the melanocortin system [0.03%]
黑皮质素系统的性别二态性及其发育与功能研究进展
Marc Claret,Roberta Haddad-Tóvolli
Marc Claret
The melanocortin system is fundamental for the regulation of whole-body energy homeostasis. This system consists of pro-opiomelanocortin (POMC) and agouti-related peptide (AgRP) neurons in the arcuate nucleus of the hypothalamus (ARH), as w...
Association between continuous glucose monitoring metrics and cardiovascular autonomic neuropathy in diabetic patients: a systematic review [0.03%]
连续葡萄糖监测指标与糖尿病患者心血管自主神经病变的关系：系统综述
Yifan Jia,Dan Long,Wei Song et al.
Yifan Jia et al.
Cardiovascular autonomic neuropathy (CAN) is a serious and prevalent complication of diabetes, linked to significant morbidity and mortality. Continuous glucose monitoring systems (CGM) provide a comprehensive and continuous glucose profile...
Bandy Chen,Jessica Furtado,Marc Schneeberger
Bandy Chen
The hypothalamus, located at the most ventral part of the brain, is the central regulator of homeostatic processes such as energy balance, autonomic functions, and reproductive regulation via the hypothalamic-pituitary-gonadal axis. The hyp...
Ricardo Rosero-Revelo,Mateo Tamayo,Ricardo Correa et al.
Ricardo Rosero-Revelo et al.
Traditional reliance on Body Mass Index (BMI) as a diagnostic tool for obesity is increasingly challenged due to its inability to differentiate between fat and lean mass and to capture fat distribution. Emerging evidence-including findings ...
Lights or shadows, a promising future for positron emission tomography in pituitary tumors: a systematic review [0.03%]
利与弊：垂体肿瘤领域正电子发射断层扫描展望：系统综述
Sabrina Chiloiro,Carmelo Caldarella,Alessandra Vicari et al.
Sabrina Chiloiro et al.
The diagnosis of pituitary adenomas (PAs), also called pituitary tumors or neuroendocrine tumors (PitNETs) currently involves assessment of blood/plasma hormone levels and traditional neuroradiological techniques, with magnetic resonance im...
Pathophysiological insights into asprosin: an emerging adipokine in reproductive health [0.03%]
Asprosin：生殖健康新兴脂肪细胞因子的发病生理学见解
Sana Khan,Saima Syeda,Yashankita Raghuvanshi et al.
Sana Khan et al.
Asprosin is a versatile protein hormone primarily produced by white adipose tissue (WAT). When secreted into the bloodstream, it exerts a range of central and peripheral effects, positioning it as a key player in metabolic processes. Since ...
Mechanisms of exercise in preventing cardiovascular diseases: Insights from gut microbiota characteristics in pathological states of cardiovascular diseases [0.03%]
运动通过肠道微生物特征预防心血管疾病的作用机制：来自心血管疾病病理状态的启示
Xingyu Qian,Yilan Guo,Peng Sun
Xingyu Qian
Cardiovascular diseases (CVD) are major lethal diseases worldwide. Imbalance of gut microbiota (GM) homeostasis affects the development and progression of CVD. Exercise can remodel GM and improve GM disorders in CVD patients. By combing the...