Effectiveness and safety of continuous subcutaneous hydrocortisone infusion in managing adrenocortical insufficiency in adult patients: a systematic review [0.03%]
连续皮下滴注氢化可的松治疗成人肾上腺皮质功能不全的有效性和安全性：一项系统综述
Yazeed Alekrish,Mohammed Alotaibi,Aishah Ekhzaimy
Yazeed Alekrish
Oral hormone replacement therapy has been and continues to be the cornerstone of adrenocortical insufficiency management. However, the introduction of continuous subcutaneous hydrocortisone infusion (CSHI) shows great potential for advancin...
Could low prolactin levels after radiotherapy predict the onset of hypopituitarism? [0.03%]
放疗后低催乳素水平能否预测垂体功能减退的发生？
Chiara Mele,Stella Pigni,Marina Caputo et al.
Chiara Mele et al.
Both local and external cranial radiotherapy (RT) can induce neurotoxicity and vascular damage of the hypothalamic-pituitary area, which can promote neuroendocrine alterations. While anterior pituitary insufficiency after RT has been extens...
Effects of glucocorticoid replacement therapy in patients with pituitary disease: A new perspective for personalized replacement therapy [0.03%]
糖皮质激素替代治疗垂体疾病患者的效果：个性化替代治疗的新视角
Sabrina Chiloiro,Alessandra Vicari,Ginevra Mongelli et al.
Sabrina Chiloiro et al.
Secondary adrenal insufficiency (SAI) is an endocrine disorder due to impaired secretion of ACTH resulting from any disease affecting the pituitary gland. Glucocorticoid replacement therapy is mandatory to ensure patient survival, haemodyna...
Andrea Palermo,Gaia Tabacco,Polyzois Makras et al.
Andrea Palermo et al.
Primary hyperparathyroidism (PHPT) is a common endocrine disease characterized by hypercalcemia due to inappropriately high parathyroid hormone secretion. While in the typical, symptomatic form of the disease diagnosis is set easily and sta...
Renata S Auriemma,Roberta Scairati,Rosa Pirchio et al.
Renata S Auriemma et al.
The fall of PRL levels below the lower limit of the normal range configures the condition of hypoprolactinemia. Unlike PRL excess, whose clinical features and treatments are well established, hypoprolactinemia has been only recently describ...
Giovanni Corona,Giulia Rastrelli,Clotilde Sparano et al.
Giovanni Corona et al.
The physiological role of prolactin (PRL) in men is still not well defined. The pathological increase is characterized by sexual function impairment along with possible negative consequences in body composition and metabolic profile. Conver...
Emre Urhan,Zuleyha Karaca
Emre Urhan
Prolactin is a polypeptide hormone composed of 199 amino acids, synthesized by lactotroph cells. Its primary effects are on the mammary gland and gonadal axes, but it also influences different organs and systems, particularly metabolic func...
Ciliopathies are responsible for short stature and insulin resistance: A systematic review of this clinical association regarding SOFT syndrome [0.03%]
纤毛病与矮小身材和胰岛素抵抗有关：关于SOFT综合征临床关联的系统性综述
Kevin Perge,Emilie Capel,Valérie Senée et al.
Kevin Perge et al.
SOFT syndrome (Short stature-Onychodysplasia-Facial dysmorphism-hypoTrichosis) is a rare primordial dwarfism syndrome caused by biallelic variants in POC1A encoding a centriolar protein. To refine the phenotypic spectrum of SOFT syndrome, r...
Inhibitors of apolipoprotein C3, triglyceride levels, and risk of pancreatitis: a systematic review and meta-analysis [0.03%]
靶向脂蛋白(a)C3的抑制剂、甘油三酯水平与胰腺炎风险：系统回顾和meta分析
Walter Masson,Martín Lobo,Juan P Nogueira et al.
Walter Masson et al.
In recent years, novel apoC3 inhibitor therapies for the treatment of hypertriglyceridemia have been developed and assessed through phase II and III clinical trials. The objective of this study was to perform an updated meta-analysis on the...
Vicki Munro,Michael Wilkinson,Syed Ali Imran
Vicki Munro
Prolactin (PRL) is primarily produced by the pituitary lactotrophic cells and while initially named for its role in lactation, PRL has several other biological roles including immunomodulation, osmotic balance, angiogenesis, calcium metabol...