Tofacitinib as a Successful Treatment for Hyper-IgE Syndrome and Autoimmunity Associated with Constitutive Activation of JAK3 [0.03%]
托法替尼成功治疗与JAK3组成型活化相关的高IgE综合征和自身免疫病
Yuxin Pei,Bei Jin,Reyila Abasi et al.
Yuxin Pei et al.
The Janus Kinase 3 (JAK3) germline gain-of-function (GOF) mutation is a rare inborn error of immunity, first reported in 2020, characterized by lymphopenia and chronic NK-cell proliferation. However, its role in autoimmunity remains unclear...
Comprehensive Profiling of T- and B-Cell Receptor Repertoires Demonstrates Impaired Developmental and Activation of Adaptive Immunity in DOCK8 Deficiency [0.03%]
DOCK8缺陷导致适应性免疫的发育和激活受损的T细胞和B细胞受体 repertoire 的全面特征描绘
Tal Beit-Halevi,Arnon Broides,Atar Lev et al.
Tal Beit-Halevi et al.
Dedicator of cytokinesis protein 8 (DOCK8) is a crucial regulator for the formation of immune synapses, allowing for a proper function of innate and adaptive immune systems. DOCK8 deficiency is a primary immunodeficiency, currently known as...
First-in-Human, Phase 1, Randomized, Double-Blind, Placebo-Controlled Study of TNX-1500, an Fc-Modified anti-CD154 Monoclonal Antibody, Evaluating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single-Ascending Doses in Healthy Adults [0.03%]
评估TNX-1500（Fc修饰的抗CD154单克隆抗体）在健康成人中单一递增剂量的安全性、耐受性、药代动力学和药效学的第一例人体I期、随机、双盲、对照I期临床试验
Seth Lederman,Bruce L Daugherty,Nancy Herje et al.
Seth Lederman et al.
Blocking CD154 (CD40L) has the potential to prolong transplanted solid organ graft survival and treat autoimmune diseases. However, first-generation anti-CD154 IgG1 monoclonal antibodies (mAbs) were associated with an increased risk of thro...
Immune Dysregulation and Persistent Symptoms: Insights into T Cell Dynamics in Post-COVID among Athletes from the CoSmo-S Study [0.03%]
免疫功能紊乱与持续症状：来自CoSmo-S研究的运动员新冠后T细胞动态的见解
Miriam Ringleb,Daniel Alexander Bizjak,Andreas Michael Nieß et al.
Miriam Ringleb et al.
Background: Over 10% of all SARS-CoV-2 infections lead to persistent symptoms, a condition called post-COVID condition (PCC). For elite athletes, whose performance is central, PCC poses significant challenges. It is sugge...
Three Doses and Six Months Later: Real-World SARS-CoV-2 Specific Humoral and Cell-Mediated Immunity in Children With Inborn Errors of Immunity [0.03%]
三剂疫苗接种及六个月后：先天性免疫缺陷儿童体内的真实世界新冠病毒特异性体液免疫和细胞介导免疫反应
Luana L T N Porto,Dina Yazji,Dana Unninayar et al.
Luana L T N Porto et al.
Hematopoietic Stem Cell Transplantation Achieves Sustained Remission in Pediatric RAS-Associated Autoimmune Lymphoproliferative Disorder with Life-Threatening Complications: a Single-Center Case Series and Literature Review [0.03%]
造血干细胞移植可使RAS相关自身免疫性淋巴细胞增生综合征患儿获得长期缓解：单中心病例系列和文献复习
Yuchen Lin,Xia Qin,Chen Zhou et al.
Yuchen Lin et al.
Translating Host-Derived Signals from Cerebrospinal Fluid Metagenomic Sequencing into a Diagnostic Tool for Autoimmune Encephalitis in Children [0.03%]
通过脑脊液元基因组测序将宿主来源信号转化为儿童自身免疫性脑炎的诊断工具
Dingding Han,Xiaozhou Pan,Fen Pan et al.
Dingding Han et al.
Adult Onset of MSMD Caused by IL-12Rβ1 Variants: Report of a Young Woman with NTM Infection Lacking Bacille Calmette-Guérin (BCG)-induced Diseases [0.03%]
成年期出现由IL-12Rβ1突变引起的遗传性免疫缺陷病（MASP）的女性报告：一例合并NTM感染但无卡介苗相关疾病的青年女性患者
Jinmei Chen,Min Xi,Weiwei Hu et al.
Jinmei Chen et al.
Antigen Microarray Reveals Broad and Subclinical Autoimmunity in Patients with Inborn Errors of Immunity [0.03%]
自身免疫抗原微阵列在先天性免疫缺陷患者中的应用
Wenjun Zhang,Bijun Sun,Wenjie Wang et al.
Wenjun Zhang et al.
TREM-1-Associated Neutrophil Extracellular Trap Formation is Linked to IVIG Resistance in Kawasaki Disease: A Convergent Transcriptomic and Prospective Validation Study [0.03%]
川崎病中与TREM-1相关的中性粒细胞胞外诱捕网形成与IVIG抵抗有关：收敛转录组学和前瞻性验证研究
Sibao Wang,Gang Luo,Zhixian Ji et al.
Sibao Wang et al.
Kawasaki disease (KD) remains the leading cause of acquired heart disease in children. While intravenous immunoglobulin (IVIG) represents standard therapy, approximately 10-20% of patients exhibit treatment refractoriness associated with si...