Exosomes Derived from ADSCs Attenuate Sepsis-Induced Lung Injury by Delivery of Circ-Fryl and Regulation of the miR-490-3p/SIRT3 Pathway [0.03%]
外泌体通过递送Circ-Fryl和调节miR-490-3p/SIRT3通路来缓解脓毒症诱导的肺损伤
Weijun Shen,Xuan Zhao,Shitong Li
Weijun Shen
Sepsis-induced lung injury is a clinical syndrome characterized by injury of alveolar epithelium cells (AECs). Previous investigations illustrate that exosomes secreted from adipose-derived stem cells (ADSCs) have therapeutic effects in a v...
Vitamin D Combined with Pioglitazone Mitigates Type-2 Diabetes-induced Hepatic Injury Through Targeting Inflammation, Apoptosis, and Oxidative Stress [0.03%]
维生素D联合吡格列酮通过靶向炎症、凋亡和氧化应激缓解2型糖尿病肝损伤
Hend A Hamouda,Suzan M Mansour,Mohammed F Elyamany
Hend A Hamouda
Inflammation is a major pathophysiological factor in development of type-2 diabetes mellitus (T2DM). Vitamin D (VITD) plays an imperative role in modulation of several inflammatory responses. The current study aimed to investigate the possi...
Dihydrotanshinone Attenuates LPS-Induced Acute Lung Injury in Mice by Upregulating LXRα [0.03%]
茋类化合物丹参二氢苊通过上调LXRα改善脂多糖诱导的小鼠急性肺损伤作用机制研究
Jing Yue,Kai Su,Guangxin Zhang et al.
Jing Yue et al.
Dihydrotanshinone (DIH) is an extract of Salvia miltiorrhiza Bunge. It has been reported that DIH could regulate NF-κB signaling pathway. The aim of this study was to investigate whether DIH could protect mice from lipopolysaccharide (LPS)...
Tenascin-C Participates Pulmonary Injury Induced by Paraquat Through Regulating TLR4 and TGF-β Signaling Pathways [0.03%]
天青蛋白C通过调节TLR4和TGF-β信号通路参与百草枯诱导的肺损伤
Di Zhang,Zhi Liu,Qianqian Liu et al.
Di Zhang et al.
This study was conducted to investigate the role of Tenascin-C (TNC) in paraquat (PQ)-induced lung injury in vivo and in vitro and explore its related mechanism during this process. Six- to eight-week-old male C57BL/6 mice were injected wit...
Circular RNA circ_0008360 Inhibits the Proliferation, Migration, and Inflammation and Promotes Apoptosis of Fibroblast-Like Synoviocytes by Regulating miR-135b-5p/HDAC4 Axis in Rheumatoid Arthritis [0.03%]
Circular RNA circ_0008360通过调节miR-135b-5p/HDAC4轴抑制类风湿性关节炎滑膜成纤维细胞的增殖、迁移、炎症并促进凋亡
Jinying Hao,Yan Chen,Yunxiang Yu
Jinying Hao
Circular RNAs (circRNAs) have been demonstrated to play crucial roles in the development and progression of many diseases, including rheumatoid arthritis (RA). However, the functions and molecular mechanism of circ_0008360 in RA remain uncl...
Network-Based Integrated Analysis of Transcriptomic Studies in Dissecting Gene Signatures for LPS-Induced Acute Lung Injury [0.03%]
基于网络的转录组学整合分析在LPS诱导急性肺损伤中的应用及基因特征解析
Fang Cao,Chunyan Wang,Danling Long et al.
Fang Cao et al.
Acute lung injury (ALI) is a type of serious clinical syndrome leading to morbidity and mortality. However, the precise pathogenesis of ALI remains elusive. Here, we implemented an integrative meta-analysis of six GEO microarray studies wit...
Meta-Analysis
Inflammation. 2021 Dec;44(6):2486-2498. DOI:10.1007/s10753-021-01518-8 2021
SHP-1/STAT3 Interaction Is Related to Luteolin-Induced Myocardial Ischemia Protection [0.03%]
SHP-1/STAT3互作与小花黄杨素诱导的心肌缺血保护相关性研究
Donghai Liu,Hong Luo,Chenhui Qiao
Donghai Liu
Prevention and management of myocardial ischemia/reperfusion (I/R) injury is a key step in coronary heart disease surgery. Luteolin is a falconoid compound that has an antioxidant effect, but its mechanism in I/R injury in vivo and in vitro...
Neuroprotective Effect of Plasminogen Activator Inhibitor-1 Antagonist in the Rat Model of Mild Traumatic Brain Injury [0.03%]
组织型纤溶酶原激活物抑制剂-1的拮抗剂对轻度脑外伤大鼠神经元的保护作用
Pınar Kuru Bektaşoğlu,Türkan Koyuncuoğlu,Selin Akbulut et al.
Pınar Kuru Bektaşoğlu et al.
Plasminogen activator inhibitor-1 (PAI-1) antagonists are known for their neuroprotective effects. In this study, it was aimed to investigate the possible protective effects of PAI-1 antagonists in a rat mild traumatic brain injury (TBI) mo...
Effects of Recombinant IL-35-BCG on Treg/Th17 Cell Imbalance and Inflammatory Response in Asthmatic Newborn Mice Induced by RSV [0.03%]
RSV诱导的新生小鼠哮喘模型中重组IL-35-BCG对Treg/Th17细胞失衡及炎性反应的影响
Wansheng Peng,Lian Wang,Hui Zhang et al.
Wansheng Peng et al.
Treg/Th17 cell imbalance and inflammatory response may occur in neonatal asthma. IL-35 and BCG have inhibitory effects on inflammatory responses in diseases. However, studies on neonatal asthma after combination of the two have not been rep...
Involvement of miR-214-3p/FOXM1 Axis During the Progression of Psoriasis [0.03%]
miR-214-3p/FOXM1轴在银屑病进展中的作用
Jin Zhao,Fei Wang,Qingjun Tian et al.
Jin Zhao et al.
Psoriasis is a common, chronic, and relapsing skin disease characterized by hyperproliferation of keratinocytes and apoptosis delay. However, the molecular mechanisms underlying the progression of psoriasis remain elusive. MicroRNAs (miRNAs...