Berberine Attenuates Neonatal Sepsis in Mice By Inhibiting FOXA1 and NF-κB Signal Transduction Via the Induction of MiR-132-3p [0.03%]
小檗碱通过诱导MiR-132-3p抑制FOXA1和NF-κB信号转导来减弱小鼠的新生儿败血症
Binghui Li,Shiping Niu,Hongli Geng et al.
Binghui Li et al.
Neonatal sepsis (NS) is a severe syndrome in newborns that is induced by infections, and the initiation and development of NS are closely associated with the function of miRs. In the current study, the effects of berberine, which is a funct...
Ameliorative Effects of Oleuropein on Lipopolysaccharide-Induced Acute Lung Injury Model in Rats [0.03%]
油橄榄苷对大鼠脂多糖诱导急性肺损伤模型的改善作用
Nursel Dikmen,Mustafa Cellat,Muhammed Etyemez et al.
Nursel Dikmen et al.
Acute lung injury (ALI) is one of the most common causes of death in diseases with septic shock. Oleuropein, one of the important components of olive leaf, has antioxidant and anti-inflammatory effects. The objective of this study was to in...
Infliximab and Tocilizumab Reduce Anxiety-Like Behaviour and Improve Cognitive Performance in a Juvenile Collagen-Induced Arthritis Rat Model [0.03%]
英夫利昔单抗和托珠单抗可降低胶原诱导的幼年 arthritis大鼠模型中的类似焦虑行为并改善认知表现
Frideriki Poutoglidou,Chryssa Pourzitaki,Maria Eleni Manthou et al.
Frideriki Poutoglidou et al.
Anxiety disorders and cognitive decline are highly prevalent in rheumatic diseases, including Juvenile Idiopathic Arthritis (JIA). In this study, we investigated the effect of long-term treatment with infliximab and tocilizumab on anxiety-l...
Lactobacillus rhamnosus Affects Rat Peritoneal Cavity Cell Response to Stimulation with Gut Microbiota: Focus on the Host Innate Immunity [0.03%]
肠菌群刺激下乳杆菌鼠李糖菌株对大鼠腹腔细胞的影响：侧重于宿主先天免疫性反应
Stanislava Stanojević,Veljko Blagojević,Ivana Ćuruvija et al.
Stanislava Stanojević et al.
Gut microbiota contribute to shaping the immune repertoire of the host, whereas probiotics may exert beneficial effects by modulating immune responses. Having in mind the differences in both the composition of gut microbiota and the immune ...
Comparative Study
Inflammation. 2021 Dec;44(6):2429-2447. DOI:10.1007/s10753-021-01513-z 2021
Nrf2 Alleviates Cognitive Dysfunction and Brain Inflammatory Injury via Mediating Wfs1 in Rats with Depression-Like Behaviors [0.03%]
Nrf2通过介导Wfs1缓解抑郁样行为大鼠的认知功能障碍和脑炎性损伤
Xuezhu Huang,Qing Qu,Dongmei Ren
Xuezhu Huang
Depression is a major threat to global mental health and demands targeted therapeutic regimens. The current study set out to evaluate the regulatory mechanism of nuclear factor erythroid-2 related factor 2 (Nrf2) in depression-induced cogni...
gC1qR Antibody Can Modulate Endothelial Cell Permeability in Angioedema [0.03%]
补体蛋白C1q的抗体可以调节血管性水肿中的内皮细胞通透性
Marina Fandaros,Kusumam Joseph,Allen P Kaplan et al.
Marina Fandaros et al.
Angioedema is characterized by swelling of the skin or mucous membranes. Overproduction of the vasodilator bradykinin (BK) is an important contributor to the disease pathology, which causes rapid increase in vascular permeability. BK format...
Selenium-Containing Compound Ameliorates Lipopolysaccharide-Induced Acute Lung Injury via Regulating the MAPK/AP-1 Pathway [0.03%]
硒化合物通过调节MAPK/AP-1信号通路改善脂多糖诱导的急性肺损伤
Wenjing Jia,Wenting Ding,Xinmiao Chen et al.
Wenjing Jia et al.
Abstract-Acute lung injury (ALI) is characterized by a series of inflammatory reactions and serves as the main cause of mortality in intensive care unit patients. Although great progress has been made in understanding the pathophysiology of...
Fei Chen,Min Yu,Yonghong Zhong et al.
Fei Chen et al.
Asthma is a common chronic respiratory disease that affects millions of people worldwide. The incidence of asthma has continued to increase every year. Bronchial asthma involves a variety of cells, including airway inflammatory cells, struc...
Repurposing Methotrexate in Dampening SARS-CoV2-S1-Mediated IL6 Expression: Lessons Learnt from Lung Cancer [0.03%]
甲氨蝶呤再利用以抑制SARS-CoV-2-S1介导的IL6表达：来自肺癌的经验教训
Pruthvi Gowda,Shruti Patrick,Shanker Datt Joshi et al.
Pruthvi Gowda et al.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (COVID-19) is associated with uncontrolled inflammatory responses. Loss of pulmonary angiotensin-converting enzyme 2 (ACE2) function has been associated with SARS-CoV-2 ...
Supervillin Contributes to LPS-induced Inflammatory Response in THP-1 Cell-derived Macrophages [0.03%]
Supervillin参与LPS诱导的THP-1细胞源巨噬炎性反应
Jun Zhou,Yuhui Que,Lihua Pan et al.
Jun Zhou et al.
Supervillin (SVIL) is an actin-binding and membrane-associated protein, which belongs to villin/gelsolin family. It has been reported that SVIL was involved in the regulation of macrophages' movement and lipopolysaccharide (LPS) increased t...