Mechanism of Baicalein in Brain Injury After Intracerebral Hemorrhage by Inhibiting the ROS/NLRP3 Inflammasome Pathway [0.03%]
黄芩素通过抑制ROS/NLRP3炎性小体通路在脑出血后脑损伤中的机制研究
Xuan Chen,Yue Zhou,Shanshan Wang et al.
Xuan Chen et al.
Intracerebral hemorrhage (ICH) is a devastating subtype of stroke with high disability/mortality. Baicalein has strong anti-inflammatory activity. This study aims to explore the mechanism of baicalein on brain injury after ICH. The model of...
Performance of High Mobility Protein Group 1 and Interleukin-6 as Predictors of Outcomes Resulting from Variceal Bleeding in Patients with Advanced Chronic Liver Disease [0.03%]
高迁移率族蛋白1和白细胞介素-6作为预测慢性肝病晚期食管静脉曲张出血预后的指标的性能研究
Camilla Dos Santos Pinheiro,Célio Geraldo de Oliveira Gomes,Camilla Ribeiro Lima Machado et al.
Camilla Dos Santos Pinheiro et al.
Variceal bleeding is a serious complication in cirrhotic patients and is related to increased expression of inflammatory mediators that accentuate circulatory dysfunction. The study aims to evaluate the performance of high mobility protein ...
Oleuropein Protects Human Retinal Pigment Epithelium Cells from IL-1β-Induced Inflammation by Blocking MAPK/NF-κB Signaling Pathways [0.03%]
橄榄苦素通过阻断MAPK/NF-κB信号通路保护人视网膜色素上皮细胞免受IL-1β诱导的炎症损伤
Ming-Lung Hsu,Wen-Chung Huang,Yi-Rong Zhou et al.
Ming-Lung Hsu et al.
Proinflammatory mediators such as interleukin (IL)-1β cause retinal pigment epithelium (RPE) inflammation, which is related to visual deterioration, including age-related macular degeneration and diabetic retinopathy. Oleuropein is a polyp...
PDCD4 Simultaneously Promotes Microglia Activation via PDCD4-MAPK-NF-κB Positive Loop and Facilitates Neuron Apoptosis During Neuroinflammation [0.03%]
在神经炎症过程中，PDCD4通过PDCD4-MAPK-NF-κB正反馈环路促进小胶质细胞活化并促使神经元凋亡
Quan Chen,Hongjian Lu,Chengwei Duan et al.
Quan Chen et al.
Neuroinflammation and neuron injury are common features of the central nervous system (CNS) diseases. It is of great significance to identify their shared key regulatory molecules and thus explore the potential therapeutic targets. Programm...
Mast Cells Modulate the Immune Response and Redox Status of the Gastrointestinal Tract in Induced Venom Pathogenesis [0.03%]
肥大细胞调节诱发毒液病理状态下胃肠免疫反应和氧化还原状态
Nehla Zerarka-Chabane,Fatima Laraba-Djebari,Djelila Hammoudi-Triki
Nehla Zerarka-Chabane
The pathogenesis of Androctonus autralis hector (Aah) scorpion venom involved cellular and molecular mechanisms resulting in multi-organ dysfunction. However, little is reported about the effects of venom on the gastrointestinal axis. Mast ...
Novel Combined Preparation and Investigation of Bergenin-Loaded Albumin Nanoparticles for the Treatment of Acute Lung Injury: In Vitro and In Vivo Evaluations [0.03%]
黄芩苷白蛋白纳米颗粒作为急性肺损伤治疗药物的制备及其体内外评价研究新进展
Hui Lin,Pengfei Wang,Wanhong Zhang et al.
Hui Lin et al.
A new method for targeting lung infections is of great interest using biodegradable nanoparticles. In this study, bergenin-loaded BSA NPs were developed against lung injury. Briefly, bergenin-loaded bovine serum albumin nanoparticles (BG@BS...
Exosomes Secreted by Mesenchymal Stem Cells Induce Immune Tolerance to Mouse Kidney Transplantation via Transporting LncRNA DANCR [0.03%]
通过运输长链非编码RNA DANCR，间充质干细胞分泌的外泌体诱导小鼠肾移植免疫耐受
Xiaoqiang Wu,Zhiwei Wang,Junpeng Wang et al.
Xiaoqiang Wu et al.
Mesenchymal stem cells induce kidney transplant tolerance by increasing regulatory T (Treg) cells. Bone marrow mesenchymal stem cell exosomes (BMMSC-Ex) promote Treg cell differentiation. Long non-coding RNA differentiation antagonizing non...
Crosstalk Between RPE Cells and Choroidal Endothelial Cells via the ANXA1/FPR2/SHP2/NLRP3 Inflammasome/Pyroptosis Axis Promotes Choroidal Neovascularization [0.03%]
RPE细胞和脉络膜内皮细胞之间的ANXA1/FPR2/SHP2/NLRP3炎性体/焦亡轴的旁分泌 Crosstalk 促进脉络膜新生血管的形成
Manhui Zhu,Ying Wang,Linling Zhu et al.
Manhui Zhu et al.
One type of age-related macular degeneration (AMD), neovascular (nAMD), characterized by choroidal neovascularization (CNV), accounts for the majority of the severe central vision impairment associated with AMD. Endothelial cells (ECs) in d...
Ulinastatin Attenuates LPS-Induced Inflammation and Inhibits Endoplasmic Reticulum Stress-Induced Apoptosis in Renal Tubular Epithelial Cells via Regulation of the TLR4/NF-κB and Nrf2/HO-1 Pathways [0.03%]
乌林斯塔틴通过调节TLR4/NF-κB和Nrf2/HO-1通路减轻LPS诱导的炎症并抑制内质网应激诱导的肾小管上皮细胞凋亡
Feixiang Chen,Jiadong Zhu,Wei Wang
Feixiang Chen
Acute kidney injury (AKI) is one of the most common diseases in patients treated in intensive care units. This study was intended to explore the underlying mechanism by which ulinastatin (UTI) influenced the inflammation and apoptosis of re...
Negative Regulators of Inflammation Response to the Dynamic Expression of Cytokines in DF-1 and MDCK Cells Infected by Avian Influenza Viruses [0.03%]
禽流感病毒感染的DF-1和MDCK细胞中炎性反应负调控因子对细胞因子动态表达的影响
Bingqian Zhao,Huizi Li,Suilan Cao et al.
Bingqian Zhao et al.
The H5N1 and H9N2 avian influenza viruses (AIVs) seriously endanger the poultry industry and threaten human health. Characteristic inflammatory responses caused by H5N1 and H9N2 AIVs in birds and mammals result in unique clinical manifestat...