Decline in Mast Cell Density During Diffuse Alveolar Damage in Idiopathic Pulmonary Fibrosis [0.03%]
特发性肺纤维化时弥漫性肺泡损伤过程中肥大细胞密度的下降
Johanna Salonen,Mervi Kreus,Siri Lehtonen et al.
Johanna Salonen et al.
Mast cells (MCs) are known to be involved in the pathogenesis of idiopathic pulmonary fibrosis (IPF), although their role in acute exacerbations of IPF has not been investigated. The aims of the study were to evaluate the numbers of MCs in ...
Mesenchymal Stem Cell-Derived Extracellular Vesicles Inhibit Osteoporosis via MicroRNA-27a-Induced Inhibition of DKK2-Mediated Wnt/β-Catenin Pathway [0.03%]
间充质干细胞衍生的细胞外囊泡通过microRNA-27a诱导抑制DKK2介导的Wnt/β-catenin通路来抑制骨质疏松症
Yan Wang,Xiaoqi Zhou,Dalin Wang
Yan Wang
Osteoporosis (OP) is a systemic skeletal disease that promotes bone fragility and the risk of fractures. Recent studies have shown the relevance of microRNAs (miRNAs) in the development of OP. This study aimed to evaluate the possible mecha...
Deoxycholic Acid Promotes Pyroptosis in Free Fatty Acid-Induced Steatotic Hepatocytes by Inhibiting PINK1-Mediated Mitophagy [0.03%]
脱氧胆酸通过抑制PINK1介导的线粒体自噬促进脂肪酸诱导的脂肪变性肝细胞的焦亡反应
Xuebin Gao,Yongdui Ruan,Xuan Zhu et al.
Xuebin Gao et al.
Nonalcoholic steatohepatitis (NASH) is the inflammatory subtype of nonalcoholic fatty liver disease (NAFLD), which can lead to liver fibrosis and cirrhosis. Bile acid levels are correlated with markers of hepatic injury in NASH, suggesting ...
Simultaneous Modulation of NLRP3 Inflammasome and Nrf2/ARE Pathway Rescues Thioacetamide-Induced Hepatic Damage in Mice: Role of Oxidative Stress and Inflammation [0.03%]
NLRP3炎症小体和Nrf2/ARE通路的同时调节可以挽救小鼠因硫代乙酰胺引起的肝脏损伤：氧化应激和炎症的作用
Durgesh Kumar Dwivedi,G B Jena
Durgesh Kumar Dwivedi
Chronic tissue injury resulting in fibrosis of multiple organs, responsible for one-third of the death globally. Liver fibrosis is a common pathway/condition involved in all chronic liver diseases. Thioacetamide (TAA), a hepatotoxicant, was...
Links Between Gut Dysbiosis and Neurotransmitter Disturbance in Chronic Restraint Stress-Induced Depressive Behaviours: the Role of Inflammation [0.03%]
慢性束缚应激诱导抑郁行为中肠道菌群失调和神经递质紊乱之间的联系：炎症的作用
Hai-Long Yang,Meng-Meng Li,Man-Fei Zhou et al.
Hai-Long Yang et al.
Accumulating evidence has shown that inflammation, the gut microbiota, and neurotransmitters are closely associated with the pathophysiology of depression. However, the links between the gut microbiota and neurotransmitter metabolism remain...
Unfractionated Heparin Attenuated Histone-Induced Pulmonary Syndecan-1 Degradation in Mice: a Preliminary Study on the Roles of Heparinase Pathway [0.03%]
未分级肝素在小鼠模型中抑制由组蛋白诱导的肺sdcan-1降解：对肝素酶通路作用的初步研究
Sifeng Fu,Sihan Yu,Yilin Zhao et al.
Sifeng Fu et al.
Endothelial glycocalyx degradation is thought to facilitate the development of sepsis. Histone is a significant mediator in sepsis. Unfractionated heparin (UFH) possessed beneficial effects on sepsis. Thereby, this study aims to figure out ...
Dietary Docosahexaenoic Acid as a Potential Treatment for Semi-acute and Chronic Particle-Induced Pulmonary Inflammation in Balb/c Mice [0.03%]
膳食二十二碳六烯酸作为BALB/C小鼠半急性及慢性颗粒物诱导肺部炎症的潜在治疗研究
Paige Fletcher,Raymond F Hamilton Jr,Joseph F Rhoderick et al.
Paige Fletcher et al.
Acute and chronic inflammation are vital contributing factors to pulmonary diseases which can be triggered by exposure to occupational and man-made particles; however, there are no established treatments. One potential treatment shown to ha...
The miR-223-3p Regulates Pyroptosis Through NLRP3-Caspase 1-GSDMD Signal Axis in Periodontitis [0.03%]
miR-223-3p通过NLRP3-Caspase 1-GSDMD信号轴调控牙周病中的焦亡过程
Yiru Xia,Kecong Zhou,Mengjun Sun et al.
Yiru Xia et al.
Salivary exosomes contain various components and may play important roles in oral diseases. The purpose of this study was to verify the possible function of miR-223-3p from salivary exosomes in periodontitis. We isolated the salivary exosom...
Increased Plasma YKL-40 Level and Chitotriosidase Activity in Cystic Fibrosis Patients [0.03%]
囊性纤维化患者血浆YKL-40水平和几丁质酶活性升高
Dilara Bal Topcu,Gokcen Tugcu,Berrin Er et al.
Dilara Bal Topcu et al.
We investigated plasma YKL-40 levels and chitotriosidase (CHIT1) activity in patients with cystic fibrosis (CF) lung disease and evaluated clinically relevant factors that may affect their levels. Plasma samples were obtained from pediatric...
A New Hybrid Protein Is a Novel Regulator for Experimental Colitis in Rats [0.03%]
一种新的杂合蛋白是大鼠实验性结肠炎的新调节因子
Kohki Okada,Masaki Ikemoto
Kohki Okada
We newly developed a hybrid protein, tentatively named rMIKO-1, using gene technology. We herein investigated the effects of rMIKO-1 on activated macrophages and discussed its potential as a suppressor of experimental colitis. Fluorescent m...