The Emerging Roles of T Helper Cell Subsets and Cytokines in Severe Neutrophilic Asthma [0.03%]
T辅助细胞亚群及细胞因子在重度嗜中性粒细胞性哮喘中的新兴作用
Qi Chen,Siji Nian,Yingchun Ye et al.
Qi Chen et al.
Neutrophilic asthma (NA) is a severe type of steroid resistant asthma, and so far the immune mechanisms underlying NA are not clear. In this article, we performed a comprehensive assessment of Th-cell subsets and cytokines in severe NA pati...
Both Baicalein and Gallocatechin Gallate Effectively Inhibit SARS-CoV-2 Replication by Targeting Mpro and Sepsis in Mice [0.03%]
两国黄芩素和表没食子儿茶素没食子酸酯通过靶向Mpro和败血症有效抑制SARS-CoV-2复制小鼠中的病毒复制
Ting Xiao,Mengqi Cui,Caijuan Zheng et al.
Ting Xiao et al.
The emergence of severe acute syndrome coronavirus 2 (SARS-CoV-2) in December 2019 has led to the global COVID-19 pandemic. Although the symptoms of most COVID-19 patients are mild or self-curable, most of severe patients have sepsis caused...
Protection of CAPE-pNO2 Against Chronic Myocardial Ischemia by the TGF-Β1/Galectin-3 Pathway In Vivo and In Vitro [0.03%]
CAPE-pNO2通过TGF-β1/Galectin-3通路对慢性心肌缺血的保护作用体内和体外研究
Qin Wan,Liwen Zhang,Qidi Zhou et al.
Qin Wan et al.
Although it is known that caffeic acid phenethyl ester (CAPE) and its derivatives could ameliorate acute myocardial injury, their effects on chronic myocardial ischemia (CMI) were not reported. This study aimed to investigate the potential ...
Syringaresinol Resisted Sepsis-Induced Acute Lung Injury by Suppressing Pyroptosis Via the Oestrogen Receptor-β Signalling Pathway [0.03%]
通过雌激素受体-β信号通路抑制焦亡从而抵抗脓毒症诱导的急性肺损伤的紫丁香树脂酚
Yuzhen Zhuo,Lei Yang,Dihua Li et al.
Yuzhen Zhuo et al.
Acute lung injury (ALI) is a common lung disease characterized by severe acute inflammatory lung injury in patients with sepsis. Syringaresinol (SYR) has been reported to have anti-apoptotic and anti-inflammatory effects, but whether it cou...
Short-Chain Fatty Acid Decreases the Expression of CEBPB to Inhibit miR-145-Mediated DUSP6 and Thus Further Suppresses Intestinal Inflammation [0.03%]
短链脂肪酸通过降低CEBPB的表达来抑制miR-145介导的DUSP6，从而进一步抑制肠道炎症
Qian Liu,Zemin Peng,Lin Zhou et al.
Qian Liu et al.
Intestinal inflammation is a common disease which can further lead to inflammatory bowel disease and even intestinal cancer. The increasing focus has come to the role of short-chain fatty acid (SCFA) in various bowel diseases. Hence, this s...
Emodin Attenuates LPS-Induced Acute Lung Injury by Inhibiting NLRP3 Inflammasome-Dependent Pyroptosis Signaling Pathway In vitro and In vivo [0.03%]
emodin通过抑制NLRP3炎性小体依赖的焦亡信号通路减轻LPS诱导的急性肺损伤(体内和体外)
Yuhan Liu,Luorui Shang,Jiabin Zhou et al.
Yuhan Liu et al.
Emodin, the effective component of the traditional Chinese medicine Dahuang, has anti-inflammatory effects. However, the protective effects and potential mechanisms of emodin are not clear. This study investigated the protective effects and...
AGE/Non-AGE Glycation: An Important Event in Rheumatoid Arthritis Pathophysiology [0.03%]
AGE/非AGE糖基化：在类风湿性关节炎病理生理过程中一个重要事件
Monu,Prachi Agnihotri,Sagarika Biswas
Monu
Rheumatoid arthritis (RA) is a chronic inflammatory, autoimmune disease that gradually affects the synovial membrane and joints. Many intrinsic and/or extrinsic factors are crucial in making RA pathology challenging throughout the disease. ...
Methyl Butyrate Alleviates Experimental Autoimmune Encephalomyelitis and Regulates the Balance of Effector T Cells and Regulatory T Cells [0.03%]
甲基丁酸盐缓解实验性自身免疫性脑脊髓炎并调节效应T细胞和调节T细胞的平衡
Chun Wang,Jingshu Yang,Ling Xie et al.
Chun Wang et al.
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS), characterized by demyelinating neuropathy. The etiology of MS is not yet clear and its treatment remains a major medical challenge. While we search for dr...
TRIM32 Inhibition Attenuates Apoptosis, Oxidative Stress, and Inflammatory Injury in Podocytes Induced by High Glucose by Modulating the Akt/GSK-3β/Nrf2 Pathway [0.03%]
通过调节Akt / GSK-3β/Nrf2通路抑制TRIM32可减轻高糖诱导的足细胞凋亡，氧化应激和炎症损伤
Zhao Chen,Lifang Tian,Li Wang et al.
Zhao Chen et al.
Hyperglycemia-induced oxidative stress in podocytes exerts a major role in the pathological process of diabetic nephropathy. Tripartite motif-containing protein 32 (TRIM32) has been reported to be a key protein in the modulation of cellular...
Long Non-Coding RNA NEAT1 Knockdown Alleviates Rheumatoid Arthritis by Reducing IL-18 through p300/CBP Repression [0.03%]
长链非编码RNA NEAT1的敲低通过抑制p300 / CBP来减少IL-18从而缓解类风湿关节炎
Tuanmao Guo,Yanli Xing,Zhongning Chen et al.
Tuanmao Guo et al.
Rheumatoid arthritis (RA) is chronic inflammatory autoimmune disease. The crucial role of long non-coding RNA (lncRNA) in the progression of RA has been highlighted. Hence, this study was designed to explore the specific downstream mechanis...