Diallyl Disulfide Attenuates STAT3 and NF-κB Pathway Through PPAR-γ Activation in Cerulein-Induced Acute Pancreatitis and Associated Lung Injury in Mice [0.03%]
阿魏酸抑制白术茋和NF-κB信号通路通过PPAR-γ激活在 cerulein诱导的急性胰腺炎及并发病变中的作用
Mathan Kumar Marimuthu,Anbalagan Moorthy,Tamizhselvi Ramasamy
Mathan Kumar Marimuthu
We have previously shown that diallyl disulfide (DADS) protects mice against cerulein-induced acute pancreatitis (AP) and associated lung injury. However, the molecular mechanisms underlying its effect and the components involved have not b...
Enhanced Responsive Formation of Extracellular Traps in Macrophages Previously Exposed to Porphyromonas gingivalis [0.03%]
牙龈卟啉单胞菌先前暴露的巨噬细胞中增强的反应性细胞外陷阱形成
Yu-Jie Liu,Jia-Lu Chen,Zi-Bo Fu et al.
Yu-Jie Liu et al.
Tolerance is defined to be a hyporesponsive state following repeated stimulations with bacteria or their virulence factors and has potential impacts on the development of periodontitis. Recently, macrophages have been reported to release ch...
The Therapeutic Effect of an Anti-TNF-α/HSA/IL-6R Triple-Specific Fusion Protein Under Experimental Septic Conditions [0.03%]
实验性脓毒症条件下抗TNF-α/HSA/IL-6R三特异融合蛋白的治疗作用研究
Xiaole Chen,Shuangyu Tan,Mengru Yan et al.
Xiaole Chen et al.
Sepsis caused by a dysregulated host response to infection is a life-threatening disease that can lead to organ dysfunction. Due to its unclear and complex mechanism, effective medicine for the treatment of sepsis is urgently required. The ...
The Priming Potential of Interferon Lambda-1 for Antiviral Defense in the Oral Mucosa [0.03%]
I型干扰素λ-1在口腔粘膜抗病毒防御中的启动潜能研究
Yosuke Shikama,Mie Kurosawa,Masae Furukawa et al.
Yosuke Shikama et al.
The oral mucosa is one of the first lines of the innate host defense system against microbial invasion. Interferon (IFN) lambda-1 (IFN-λ1), a type III IFN, exhibits type I IFN-like antiviral activity. In contrast to ubiquitously expressed ...
Metabolomics of Synovial Fluid and Infrapatellar Fat Pad in Patients with Osteoarthritis or Rheumatoid Arthritis [0.03%]
骨关节炎或类风湿性关节炎患者滑液和髌下脂肪垫的代谢组学研究
Petteri Nieminen,Wilhelmiina Hämäläinen,Juha Savinainen et al.
Petteri Nieminen et al.
Osteoarthritis (OA) and autoimmune-driven rheumatoid arthritis (RA) are inflammatory joint diseases with complex and insufficiently understood pathogeneses. Our objective was to characterize the metabolic fingerprints of synovial fluid (SF)...
Influence of Pinealectomy and Long-term Melatonin Administration on Inflammation and Oxidative Stress in Experimental Gouty Arthritis [0.03%]
pinealectomy和长期给予褪黑素对实验性痛风关节炎炎症及氧化应激的影响
Arwa Fadil Haqi Ballur,Eyup Altinoz,Gurkan Yigitturk et al.
Arwa Fadil Haqi Ballur et al.
Gout is an inflammatory arthritis characterized by the deposition of monosodium urate (MSU) crystals in the joints or soft tissue. MSU crystals are potent inflammation inducers. Melatonin (MLT) is a powerful endogenous anti-inflammatory age...
Expression Pattern and Immunoregulatory Roles of Galectin-1 and Galectin-3 in Atopic Dermatitis and Psoriasis [0.03%]
半乳糖凝集素-1和半乳糖凝集素-3在特应性皮炎和银屑病中表达模式及免疫调节作用的研究
Mab P Corrêa,Rebeca D Correia-Silva,Gisela R Silva Sasso et al.
Mab P Corrêa et al.
The pathogenesis of atopic dermatitis (AD) and psoriasis (Ps) overlaps, particularly the activation of the immune response and tissue damage. Here, we evaluated galectin (Gal)-1 and Gal-3 levels, which are beta-galactoside-binding proteins ...
Sigma-1 Receptor Alleviates Airway Inflammation and Airway Remodeling Through AMPK/CXCR4 Signal Pathway [0.03%]
σ-1受体通过AMPK/CXCR4信号通路缓解气道炎症和气道重塑作用研究
Te Jiang,Di Zhao,Zhiyuan Zheng et al.
Te Jiang et al.
Sigma non-opioid intracellular receptor 1 (Sigma-1R) has been proven to play a major role in inflammation and structural remodeling. However, its role in airway inflammation and airway remodeling remains unclear. The purpose of this study a...
Enrichment of Newly Synthesized Proteins following treatment of C2C12 Myotubes with Endotoxin and Interferon-γ [0.03%]
内毒素和干扰素-γ处理后C2C12肌管新生蛋白质的富集
Catherine S Coleman,Bruce A Stanley,Charles H Lang
Catherine S Coleman
Inflammation in muscle induces the synthesis of mediators that can impair protein synthesis and enhance proteolysis, and when sustained lead to muscle atrophy. Furthermore, muscle-derived mediators that are secreted may participate in disru...
Cryptococcus neoformans in Association with Dermatophagoides pteronyssinus has Pro- (IL-6/STAT3 Overproduction) and Anti-inflammatory (CCL2/ERK1/2 Downregulation) Effects on Human Bronchial Epithelial Cells [0.03%]
新生隐球菌与皮屑螨对人支气管上皮细胞的促炎(IL-6/STAT3过表达)和抗炎(CCL2/ERK1/2下调)作用
Henrique Ismarsi Souza,Aline Beatriz Mahler Pereira,Jhony Robison Oliveira et al.
Henrique Ismarsi Souza et al.
Cryptococcosis (caused, for example, by Cryptococcus neoformans) and allergic asthma (caused, for example, by Dermatophagoides pteronyssinus) target the respiratory tract (the lung and bronchial epithelium). C. neoformans and D. pteronyssin...