Obesity-induced Nerve Degeneration and Inflammation: Therapeutic Effects of β-Hydroxybutyrate and Melatonin on Pyroptosis, ER Stress, and Hippocampal Dysfunction in High-Fat Diet-Fed Rats [0.03%]
肥胖诱导的神经退行性和炎症：β-羟基丁酸和褪黑素对高脂饮食喂养大鼠_PYROPTOSIS、内质网应激和海马功能障碍的治疗作用
Zahra Zeynali,Mohammad Hasan Maleki,Alireza Doagoo et al.
Zahra Zeynali et al.
NLRP12 Deficiency Enhances Tofacitinib Efficacy in DSS Colitis Via STAT1-M1 Polarization [0.03%]
NLRP12缺陷通过STAT1-M1极化增强托法替尼在DSS结肠炎中的疗效
Yun Yi,Qiaofang Wei,Siyu Chen et al.
Yun Yi et al.
Tofacitinib, an oral pan-Janus kinase (JAK) inhibitor, induces rapid remission in ulcerative colitis (UC), but only ~60% of patients respond, highlighting the need for biomarkers to guide therapy. NLRP12, a NOD-like receptor, negatively reg...
Oxidized Phospholipids Aggravate Hepatic Ischemia/Reperfusion Injury by Promoting Macrophage M1 Polarization Via Regulating the Wnt/β-catenin/Autophagy Axis [0.03%]
氧化磷脂通过调节Wnt/β-猫眼素自噬轴促进M1型巨噬细胞极化从而加剧肝缺血再灌注损伤
Minhao Chen,Yue Liu,Jie Li et al.
Minhao Chen et al.
TM9SF1 Aggravates Liver Ischemia-Reperfusion Injury by Promoting Autophagy [0.03%]
TM9SF1通过促进自噬加重肝脏缺血再灌注损伤
Tongtong Wu,Wendong Li,Ying Zhu et al.
Tongtong Wu et al.
Enhancing Mitophagy with PEP-1-CAT Attenuates Vascular Inflammation and Atherogenesis in Mice [0.03%]
PEP-1-过氧化氢酶增强线粒体自噬从而减轻小鼠血管炎症和动脉粥样硬化形成
Shuang Wei,Lei Zhang,Xuan-Ren Wang et al.
Shuang Wei et al.
The gradual decline of endothelial function and the intensification of inflammatory responses form the basis for the occurrence and development of age-related diseases such as atherosclerosis (AS). Mitochondrial dysfunction-manifested by ex...
Leonurine Mitigates Experimental Autoimmune Prostatitis by Modulating Macrophage M1 Polarization Through the TLR4/NF-κB Signaling Pathway [0.03%]
锦地兰通过调节TLR4/NF-κB信号途径介导的M1型巨噬细胞极化治疗实验性自身免疫前列腺炎
Rui-Jie Hu,Xiao-Long Ying,Cheng Zhang et al.
Rui-Jie Hu et al.
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) constitutes a clinically complex urological condition defined by the persistence of pelvic pain and chronic inflammation. Emerging evidence underscores the critical involvement of m...
Impaired BCAA Catabolism Contributes To Acute Lung Injury By Triggering Oxidative Stress and Inflammatory Response Via the MAPK Pathway [0.03%]
BCAA分解代谢障碍通过MAPK途径触发氧化应激和炎症反应从而促发急性肺损伤
Da-Yan Xiong,Chen-Yu Zhang,Jin-Tong Yang et al.
Da-Yan Xiong et al.
Akkermansia Muciniphila Ameliorates Imiquimod-Induced Skin Thickening, Colitis, and Gut Microbiota Alterations: A Metagenome Association Study [0.03%]
Akkermansia muciniphila改善Imiquimod诱导的皮肤增厚、结肠炎和肠道微生物群变化：一项元基因组关联研究
Yi-Ju Chen,Hsiu J Ho,Ching-Hung Tseng et al.
Yi-Ju Chen et al.
IFN-γ and TNF-α Impair Lung Development by Upregulating SMAD7 to Inhibit TGF-β Signaling Pathway and ECM Dysregulation [0.03%]
干扰素γ和肿瘤坏死因子α通过上调SMAD7抑制TGF-β信号通路及细胞外基质失调从而影响肺的发育
Xiaotian Liao,Weiliang Huang,Jianwei Wei et al.
Xiaotian Liao et al.
Inflammation plays a pivotal role in neonatal lung injury and is closely associated with the pathogenesis of bronchopulmonary dysplasia (BPD) in preterm infants, although the underlying molecular mechanisms remain incompletely understood. O...
FTO-dependent m6A Demethylation Activates Mxd1 To Enhance Vitamin D-induced Suppression of Neuroinflammation Via PTEN/AKT/PGC-1α Signaling Pathways in Microglia [0.03%]
FTO依赖的mRNA去甲基化激活Mxd1以增强维生素D诱导的小胶质细胞抗炎作用及PTEN/AKT/PGC-1α信号通路的研究
Zhenzhen Hu,Rui Liu,Biyun Zhang et al.
Zhenzhen Hu et al.
Neuroinflammation, driven primarily by activated microglia, is a key contributor to neurological disorders. A promising therapeutic approach involves reprogramming microglia from a pro-inflammatory (M1) to an anti-inflammatory (M2) phenotyp...