Treatment with Polyethylene Glycol-Conjugated Fungal D-Amino Acid Oxidase Reduces Lung Inflammation in a Mouse Model of Chronic Granulomatous Disease [0.03%]
聚乙二醇化真菌D-氨基酸氧化酶治疗可减轻慢性肉芽肿病小鼠模型的肺部炎症
Hiroyuki Nunoi,Peiyu Xie,Hideaki Nakamura et al.
Hiroyuki Nunoi et al.
Chronic granulomatous disease (CGD) is a primary immunodeficiency wherein phagocytes are unable to produce reactive oxygen species (ROS) owing to a defect in the nicotinamide adenine dinucleotide phosphate oxidase (NADPH) complex. Patients ...
The Prospective Effect of Allopurinol on the Oxidative Stress Index and Endothelial Dysfunction in Covid-19 [0.03%]
探究秋水仙碱对新冠病毒感染相关氧化应激指数及内皮功能障碍的前瞻性影响研究
Hayder M Al-Kuraishy,Ali I Al-Gareeb,Marwa S Al-Niemi et al.
Hayder M Al-Kuraishy et al.
SARS-CoV-2 by the direct cytopathic effect or indirectly through the propagation of pro-inflammatory cytokines could cause endothelial dysfunction (ED) and oxidative stress (OS). It has been reported that OS is triggered by various types of...
MEFV and NLRP3 Inflammasome Expression Is Attributed to Immature Macrophages and Correlates with Serum Inflammatory Proteins in Crohn´s Disease Patients [0.03%]
MEFV和NLRP3炎性小体的表达与不成熟巨噬细胞相关并与克罗恩病患者血清炎症蛋白有关
Frida Gorreja,Charles Caër,Stephen T A Rush et al.
Frida Gorreja et al.
Inflammasomes are intracellular protein complexes whose activation results in proinflammatory cytokines. Inflammasomes are implicated in Crohn´s disease (CD) pathogenesis, yet the contribution of inflammasomes in intestinal epithelial cell...
HHLA2 Activates the JAK/STAT Signaling Pathway by Binding to TMIGD2 in Hepatocellular Carcinoma Cells [0.03%]
HHLA2通过与TMIGD2结合在肝癌细胞中激活JAK/STAT信号通路
Hui Guo,Cheng Zhang,Xiaotong Tang et al.
Hui Guo et al.
HHLA2, a member of the B7 family of immune checkpoint players, has been implicated in various cancers. The study set to determine the expression and biological function of HHLA2 in hepatocellular carcinoma (HCC), and its connection to TMIGD...
Intermedin1-53 Inhibits NLRP3 Inflammasome Activation by Targeting IRE1α in Cardiac Fibrosis [0.03%]
INTERMEDIN通过靶向IRE1α抑制NLRP3炎症小体在心脏纤维化中的作用
Lin-Shuang Zhang,Jin-Sheng Zhang,Yue-Long Hou et al.
Lin-Shuang Zhang et al.
Intermedin (IMD), a paracrine/autocrine peptide, protects against cardiac fibrosis. However, the underlying mechanism remains poorly understood. Previous study reports that activation of nucleotide-binding oligomerization domain (NOD)-like ...
TDAG51-Deficiency Podocytes are Protected from High-Glucose-Induced Damage Through Nrf2 Activation via the AKT-GSK-3β Pathway [0.03%]
Nrf2通过AKT-GSK-3β途径的激活保护TDAG51缺陷podocytes免受高糖诱导的损伤
Chuntian Liu,Yanling Li,Xiaojuan Wang
Chuntian Liu
T cell death-associated gene 51 (TDAG51) has been implicated in the development of various pathological conditions. However, whether TDAG51 plays a role in diabetic renal disease remains unknown. The current work investigated the possible f...
Correction to: LncRNA KCNQ1OT1 Regulates Endoplasmic Reticulum Stress to Affect Cerebral Ischemia-Reperfusion Injury Through Targeting miR-30b/GRP78 [0.03%]
Correction to：LncRNA KCNQ1OT1通过靶向miR-30b/GRP78调节内质网应激来影响脑缺血再灌注损伤
Yue Li,Ming Yi,Dan Wang et al.
Yue Li et al.
Published Erratum
Inflammation. 2022 Apr;45(2):935-936. DOI:10.1007/s10753-022-01636-x 2022
Kindlin-2 Mediates Lipopolysaccharide-Induced Acute Lung Injury Partially via Pyroptosis in Mice [0.03%]
Tlr4介导的热休克蛋白诱导树突状细胞成熟及其对调节性t细胞抑制功能的影响
Yi-Dan Huang,Yu Fang,Li Ma et al.
Yi-Dan Huang et al.
Acute lung injury (ALI) is characteristic of the wholesale destruction of the lung endothelial barrier, which results in protein-rich lung edema, influx of pro-inflammatory leukocytes, and intractable hypoxemia, contributing to high mortali...
Pink1/Parkin-Mediated Mitophagy Regulated the Apoptosis of Dendritic Cells in Sepsis [0.03%]
Pink1/Parkin介导的线粒体自噬在脓毒症树突状细胞凋亡中作用的研究
Yaolu Zhang,Longwang Chen,Yinan Luo et al.
Yaolu Zhang et al.
Dendritic cells (DCs) are vital antigen-presenting cells (APCs) in the immune system, whose apoptosis is closely related to the development of sepsis. Mitophagy is one of the necessary forms of selective autophagy that removes damaged or dy...
IL-21 Enhances the Immune Protection Induced by the Vibrio vulnificus Hemolysin A Protein [0.03%]
白细胞介素-21增强由副溶血弧菌溶血素A蛋白诱导的免疫保护作用
Ke-Na Sun,Fei Huang,Ming-Yi Wang et al.
Ke-Na Sun et al.
We previously reported that the Vibrio vulnificus hemolysin A (VvhA) protein elicited good immune protection and could effectively control V. vulnificus infection in mice. However, its molecular mechanism remains unknown. We hypothesized th...