MicroRNA-98-5p Inhibits IL-13-Induced Proliferation and Migration of Human Airway Smooth Muscle Cells by Targeting RAC1 [0.03%]
微小核糖核酸98-5p通过靶向Rac1抑制IL-13诱导的人气道平滑肌细胞增殖和迁移作用
Shaolin Zeng,Juan Cui,Yunting Zhang et al.
Shaolin Zeng et al.
The dysfunction of airway smooth muscle cells (ASMCs) is one of the key factors in the pathogenesis of asthma. How miR-98-5p works in asthma has not been completely elucidated. This work focused on how miR-98-5p functions in the proliferati...
Ex Vivo Culture Models of Hidradenitis Suppurativa for Defining Molecular Pathogenesis and Treatment Efficacy of Novel Drugs [0.03%]
HS大疱模型的体外培养体系在定义分子发病机制及评估新型药物疗效中的应用
Kayla F Goliwas,Mahendra P Kashyap,Jasim Khan et al.
Kayla F Goliwas et al.
Hidradenitis suppurativa (HS) is a complex and debilitating inflammatory skin disease for which no effective treatment is available currently. This is partly because of the lack of adequate human or animal models for defining the pathobiolo...
Fareeha Batool,Pierre-Yves Gegout,Céline Stutz et al.
Fareeha Batool et al.
The aim of this study was to evaluate the potential anti-inflammatory and anti-resorptive effects of lenabasum in the context of Porphyromonas gingivalis (Pg)-induced inflammation. Lenabasum or ajulemic acid (1',1'-dimethylheptyl-THC-11-oic...
Methoxyeugenol Protects Against Lung Inflammation and Suppresses Neutrophil Extracellular Trap Formation in an LPS-Induced Acute Lung Injury Model [0.03%]
甲氧基丁香酚对脂多糖诱导的小鼠急性肺损伤模型的保护作用及对中性粒细胞胞外陷阱形成的抑制作用研究
Géssica Luana Antunes,Lucas Strassburger Matzenbacher,Bruna Pasqualotto Costa et al.
Géssica Luana Antunes et al.
Acute lung injury (ALI) is a life-threatening acute inflammatory disease with high rates of morbidity and mortality worldwide. 4-Allyl-2,6-dimethoxyphenol (methoxyeugenol), a phenylpropanoid from a synthetic source, exhibits strong anti-inf...
Evaluating the Similarity of Different Collagen-Induced Arthritis Models to the Pre-Clinical Phase of RA in Female Rats [0.03%]
评估不同诱导型胶原性关节炎模型与雌性大鼠类风湿性关节炎临床前期的相似性
Xiaoying Lin,Qiao Wang,Zhixing He et al.
Xiaoying Lin et al.
Since the development of RA is a multistep process, it is critical to take action to prevent RA in the pre-clinical phase. Animal models are currently one of the important methods to study RA, but there are very few animal models for studyi...
Inhibitory Effects of Euscaphic Acid in the Atopic Dermatitis Model by Reducing Skin Inflammation and Intense Pruritus [0.03%]
乌药酸通过减少皮肤炎症和剧烈瘙痒在特应性皮炎模型中的抑制作用研究
Na-Hee Jeong,Soyoung Lee,Young-Ae Choi et al.
Na-Hee Jeong et al.
Atopic dermatitis (AD) is a complex and multifactorial skin disease characterized by skin inflammation and intense pruritus. There are many commercially available treatments such as topical corticosteroids and immunosuppressants to treat of...
Pre-exposure to Aerosolized Polyvalent Bacterial Lysates Protects Against Bleomycin-Induced Pulmonary Fibrosis in Mice [0.03%]
雾化吸入多价细菌裂解物预处理可保护小鼠免于博来霉素诱导的肺纤维化
Xiaoling Zhu,Shan Yuan,Xiaofang Zheng et al.
Xiaoling Zhu et al.
Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing interstitial pneumonia of unknown cause. No therapeutic modalities can reverse or stop its ever-deteriorating course. The stimulation of lung innate immunity using bacterial lysates...
Therapeutic Outcome of Anti-inflammatory and Antioxidative Medicines on the Dermonecrotic Activity of Cerastes cerastes Venom [0.03%]
抗炎和抗氧化药物治疗 cerastes 鳞蛇毒引起的皮肤坏死作用的疗效研究
Abderrezak Khelfi,Habiba Oussedik-Oumehdi,Fatima Laraba-Djebari
Abderrezak Khelfi
Envenomation by Cerastes cerastes often results in local dermonecrotic lesions. While immunotherapy is effective in reversing systemic symptoms, this strategy remains deficient in counteracting the extended dermonecrosis induced from the bi...
Effect of Aryl-Cyclohexanones and their Derivatives on Macrophage Polarization In Vitro [0.03%]
茋类化合物调节巨噬细胞极化的研究进展
Tainá L Lubschinski,Luiz A E Pollo,Eduarda T B Mohr et al.
Tainá L Lubschinski et al.
Macrophages are critical in both tissue homeostasis and inflammation, and shifts in their polarization have been indicated as pivotal for the resolution of inflammatory processes. Inflammation is a complex and necessary component of the imm...
Lactylation: a Passing Fad or the Future of Posttranslational Modification [0.03%]
乳酰化：转译后修饰研究的过眼云烟还是未来方向？
Qi Xin,Hai Wang,Qinglin Li et al.
Qi Xin et al.
Lactate is a glycolytic product and a significant energy source. Moreover, it regulates gene transcription via lactylation of histones and non-histone proteins, i.e., a novel posttranslational modification. This review summarizes recent adv...