β-Asarone Mediates the Alleviation of Neuroinflammation in Alzheimer's Disease Via Modulation of the TREM2/PI3K/AKT Signaling Pathway [0.03%]
β-asarone通过调节TREM2/PI3K/AKT信号通路介导对阿尔茨海默病神经炎症的缓解作用
Na Yang,Jiajun Jiang,Jianhong Shi et al.
Na Yang et al.
Neuroinflammation, driven by dysregulated microglial polarization, is a hallmark of Alzheimer's disease (AD). Recently, the triggering receptor expressed on myeloid cells 2 (TREM2), a key regulator of microglial function, has emerged as a p...
Single-Cell Analyses Reveal IKKα Regulates the Interaction Between Macrophages and T Cells in the Doxorubicin-Induced Cardiomyopathy [0.03%]
单细胞分析揭示IKKα调节多柔比星诱导的心肌病中小胶质细胞与T细胞的相互作用
Ganyi Chen,Yiwei Yao,Yunfei Jiang et al.
Ganyi Chen et al.
Doxorubicin (DOX) is a chemotherapeutic agent used to treat solid tumors and hematologic malignancies, though DOX-induced cardiomyopathy poses a risk of severe cardiac impairment and poor prognosis. Immune cells have been increasingly impli...
Lipopolysaccharide-Induced Nasal Inflammation Swiftly Spreads Into the Olfactory Bulb, Accelerating its Network Activity and Uncoupling it from Breathing [0.03%]
脂多糖诱导的鼻部炎症迅速扩散到嗅球，加速其网络活性并使其与呼吸脱耦合
Armando Ortega-Xique,Benito Ordaz,Jonathan-Julio Lorea-Hernández et al.
Armando Ortega-Xique et al.
Nasal inflammation-induced olfactory dysfunction is caused by sensory processing alterations in and beyond the olfactory epithelium, likely through the spreading of peripheral inflammation into the olfactory bulb (OB), damaging its neuronal...
The Acid sphingomyelinase/ceramide System in Idiopathic Inflammatory Myopathies: a Potential Treatment Target [0.03%]
自身免疫性肌炎中鞘氨醇-1-磷酸合酶/鞘氨醇-1-磷酸系统的功能异常及治疗潜力研究
Yuehong Chen,Jingyu Yang,Geng Yin et al.
Yuehong Chen et al.
FNDC5/Irisin Attenuates TGF-β-induced Fibroblast Differentiation Via AMPK/Nrf2 Signaling and Mitochondrial Stabilization in Subepithelial Fibrosis [0.03%]
FNDC5/irisin通过AMPK/Nrf2信号和线粒体稳定化减弱TGF-β诱导的成纤维细胞分化在上皮下纤维化中的作用
Wun-Hao Cheng,Yu-Chih Wu,Hsuan-Tzu Li et al.
Wun-Hao Cheng et al.
Interferon-Driven Tryptophan Metabolism Links Inflammation and Mental Health in Juvenile Dermatomyositis [0.03%]
干扰素驱动的色氨酸代谢连接了皮肌炎相关的炎症与精神健康问题
Yang Wu,Aviya L Levy,Payton Hermanson et al.
Yang Wu et al.
Background: Children with juvenile dermatomyositis (JDM) experience significant mental health burdens, including anxiety and depression. Inflammatory activation can alter tryptophan metabolism, particularly through IDO-dr...
PKM2 Promotes Glycolysis in Alveolar Macrophages and Induces Inflammation in Bronchopulmonary Dysplasia [0.03%]
PKM2促进肺泡巨噬细胞的糖酵解并诱发支气管肺发育不良炎症反应
Xingyu Mo,Huici Yao,Huimin Ju et al.
Xingyu Mo et al.
RasGRP3 Promotes RAP1B Activity to Inhibit Endothelial Inflammation and Alleviate Atherosclerosis in High-Fat Diet-Fed ApoE-/- Mice [0.03%]
Ras鸟苷酸交换因子GRP3通过促进RAP1B活化抑制血管内皮炎症并缓解高脂饮食Apoe基因敲除小鼠动脉粥样硬化病变形成
Bojian Zhang,Zheng Wei,Qingyun Zou et al.
Bojian Zhang et al.
Combining Spatial Transcriptomics and Machine Learning Unravels Fibroblast-Related Biomarkers in Ulcerative Colitis [0.03%]
结合空间转录组学和机器学习揭示溃疡性结肠炎相关成纤维细胞标志物
Kuo Kang,Xuanxuan Li,Shalong Wang et al.
Kuo Kang et al.
Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by persistent mucosal inflammation. While fibroblasts contribute to tissue repair and fibrosis, their role in UC pathogenesis remains incompletely understood. Sin...
Mast Cell Chymase and Human Lung Fibroblast Interaction: Mechanisms and Implications for Asthma [0.03%]
肺成纤维母细胞与肥大细胞炎性介质相互作用的机制及意义研究
Gunnar Pejler,Aida Paivandy,Fabio Rabelo Melo et al.
Gunnar Pejler et al.
Mast cells play a crucial role in the pathogenesis of asthma, by releasing inflammatory mediators including mast cell-specific proteases such as tryptase and chymase. However, the exact role of these proteases in asthma is not fully underst...