Palmitoylation Induced Activation of SMAD3 Exacerbates Colitis by Promoting Tissue-resident Memory T Cells Differentiation [0.03%]
棕榈酰化诱导的SMAD3活化通过促进组织驻留记忆T细胞分化加重结肠炎
Yuejie Xu,Siqi Ji,Ping Jiang et al.
Yuejie Xu et al.
Mitochondrial Pyruvate Metabolism Controls Alveolar Stem Cell Fate and Inflammatory Balance [0.03%]
线粒体丙酮酸代谢控制肺泡干细胞命运和炎性平衡
Zuokuan He,Xue Li,Xuan Miao et al.
Zuokuan He et al.
METTL3-Mediated m6A Regulation of CircINTS4/miR-146b-3p Axis in Rheumatoid Arthritis [0.03%]
METTL3介导的CircINTS4 / miR-146b-3p轴m6A甲基化在类风湿关节炎中的调控作用研究
Shu Li,MengYu Zhang,SiYu Liang et al.
Shu Li et al.
Background: Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by synovial inflammation and joint destruction. Despite advances in understanding its pathogenesis, the role of epigenetic regulation an...
MAGL Inhibition Relieves Psoriasiform Inflammation and Pruritus Via Modulation of ALOX12-12-HETE Axis in Mice [0.03%]
抑制MAGL可通过调节ALOX12-12-HETE轴缓解小鼠银屑病样炎症和瘙痒感
Shiying Lin,Xin Liu,Jian Jiang et al.
Shiying Lin et al.
The endogenous cannabinoid system, comprising endocannabinoids, cannabinoid receptors, and enzymes responsible for synthesis and degradation of endocannabinoids, is integral to the regulation of skin inflammation. However, the precise contr...
IRF7 Modulates Inflammatory Pain Through Upregulating IFNβ in Mice Trigeminal Ganglion [0.03%]
IRF7通过上调三叉神经节中IFNβ来调节小鼠炎症痛
Lijia Mai,Xiaoxia Ma,Hui Yang et al.
Lijia Mai et al.
Secondary Exposure to IMQ or Irritants Enhances Psoriasiform Recurrence Through Inflammatory Memory [0.03%]
次要的IMQ或刺激物暴露通过炎症记忆增强银屑病样复发
Wenqiu Wang,Chengxin Li,Rui Wang
Wenqiu Wang
Psoriasis relapse is frequently characterized by more pronounced inflammatory responses compared to the initial onset; however, the underlying mechanisms that drive disease recurrence remain poorly understood. This study aims to investigate...
KANK4 Regulates CXCL16 Glycosylation Through TMEM260 to Modulate Microglial Activation in Sepsis-associated Encephalopathy [0.03%]
KANK4通过TMEM260调节CXCL16糖基化以在脓毒症相关性脑病中调控小胶质细胞活化
Mao Peng,Sinian Tan,Ao Li et al.
Mao Peng et al.
Sepsis-associated encephalopathy (SAE) is a significant clinical condition leading to cognitive impairment, yet its molecular mechanisms remain to be fully elucidated. This study demonstrates that KANK4 expression is significantly downregul...
Paeoniflorin Alleviates Metabolic Dysfunction-Associated Steatotic Liver Disease by Inhibiting Hepatic Lipogenesis and Inflammation [0.03%]
芍药苷通过抑制肝脏脂质生成和炎症来缓解与代谢功能障碍相关的肝脂肪变性病
Shi-Zhang Wei,Yuan Dong,Hong-Ying Zhou et al.
Shi-Zhang Wei et al.
Proline-Mediated Inhibition of ATPIF1-mTOR Signaling Alleviates Radiation-Induced Macrophage Polarization and Colon Inflammation [0.03%]
脯氨酸介导的ATPIF1-mTOR信号抑制缓解辐射诱导的巨噬细胞极化和结肠炎症
Lei Chang,Le Zhou,Shan Jiang et al.
Lei Chang et al.
Radiation therapy often triggers inflammatory complications such as radiation colitis, which is driven by persistent M1 macrophage polarization. While metabolic reprogramming is pivotal in macrophage activation, the role of amino acid metab...
Mesaconate Alleviates Myocardial Ischemia/Reperfusion Injury and Cardiovascular Aging by Targeting GPR35 to Arrest Macrophage Inflammation [0.03%]
靶向GPR35缓解巨噬细胞炎症以减轻心肌缺血再灌注损伤和心血管衰老：美沙cona酸的作用与机制
Lei Zhu,Jun Cui,Panpan Li et al.
Lei Zhu et al.