Expression and regulation network of BLNK in CP/CPPS in animal, cell model and clinical samples [0.03%]
基于动物、细胞模型及临床样本探讨BLNK在CP/CPPS中的表达及其调控网络
Peng Yu,Jiefu Huang,Xiang Gan et al.
Peng Yu et al.
B-cell linker (BLNK) is associated with the inflammatory process of certain diseases. However, no studies have explored the role of BLNK in chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). We performed transcriptome analysis of t...
Evaluation of Cardiac IL-11 and IL-11Rα Expression During T. cruzi Infection [0.03%]
利什曼原虫感染期间心脏IL-11和IL-11Rα表达的评估
Yarlla Loyane Lira Braga,José Rodrigues do Carmo Neto,Pablo Igor Ribeiro Franco et al.
Yarlla Loyane Lira Braga et al.
Chagas disease (CD), caused by Trypanosoma cruzi, leads to cardiomyopathy in approximately 20-30% of infected individuals. Interleukin-11 (IL-11) has been implicated in cardiac fibrosis, although its immunological role in this context remai...
Identification and Experimental Validation of OS-Related Gene Sets Based on Integrated Analysis of Single-Cell and Bulk RNA Sequencing Data with Machine Learning in Patients with Sepsis [0.03%]
基于单细胞和批量RNA测序数据的集成分析结合机器学习在脓毒症患者中鉴定并实验验证与OS相关的基因集
Linfeng Tao,Wei Tian,Ping Li et al.
Linfeng Tao et al.
Sepsis is a severe organ dysfunction syndrome caused by a dysregulated host response to infection, closely associated with poor prognosis. It disrupts the balance between oxidative and antioxidative systems, which may ultimately result in c...
Angiotensin-(1-7) Mitigates Progression from Acute Kidney Injury to Chronic Kidney Disease Via Renin-Angiotensin System Modulation in a Murine Model [0.03%]
血管紧张素-(1-7)通过调节鼠肾损伤模型中的肾素-血管紧张素系统将急性肾损伤向慢性肾病进展的风险最小化
Minzi Qiu,Yanxia Chen,Siyue Huang et al.
Minzi Qiu et al.
Acute kidney injury (AKI) often progresses to chronic kidney disease (CKD), presenting a significant clinical challenge. The renin-angiotensin system (RAS), particularly the protective arm involving Angiotensin-(1-7) (Ang-(1-7)), offers a p...
Chemerin Exacerbates Pulmonary Inflammation in Type 2 Diabetes and Mycobacterium Tuberculosis Infection Comorbidity [0.03%]
2型糖尿病合并结核分枝杆菌感染共病时， Chemerin加剧肺部炎症反应
Giseli Furlan Corrêa,Núbia Sabrina Martins,Ualter Guilherme Cipriano et al.
Giseli Furlan Corrêa et al.
The adipokine chemerin is increased in the serum of individuals with obesity and type 2 diabetes. Patients with type 2 diabetes exhibit a threefold increased risk of developing tuberculosis, are more refractory to tuberculosis treatment and...
Dong-Yu Guo,Zheng-Yuan Liu,Xu-Chen Xu et al.
Dong-Yu Guo et al.
Neutrophils, the most abundant circulating leukocytes in humans, play key roles in infection and inflammation. The lungs represent a vital pool for neutrophils, serving as both a primary site of immune surveillance and a key battleground in...
Inactivated Bacillus subtilis R0179 Inhibits Porphyromonas Gingivalis-Induced Gingival Inflammation Via TLR2/NF-κB Signaling in a Murine Model of Periodontitis [0.03%]
枯草杆菌R0179的灭活菌通过TLR2/NF-κB信号抑制牙龈炎小鼠模型中齿垢密螺旋体诱导的牙龈炎症
Weiwei Zhao,Lingli Ji,Jie Li et al.
Weiwei Zhao et al.
This study aims to explore the mechanism by which heat-inactivated Bacillus subtilis (B. subtilis) R0179 modulates the TLR2/NF-κB signaling pathway to inhibit Porphyromonas gingivalis (P. gingivalis) induced gingival inflammation. In vitro...
Membrane-Associated RING-CH-Type Finger 6 Protects against Hypertension-Induced Cardiac Remodeling by Suppressing Cardiomyocyte Ferroptosis Through the Degradation of ACSL4 [0.03%]
利用泛素连接酶MARK6降解ACSL4抑制心肌细胞铁死亡从而保护高血压诱导的心脏重构
Rui Hao,Xin Wang,Changhu Liu et al.
Rui Hao et al.
Hypertension serves as a major contributing factor to various cardiovascular disorders, including heart failure. Ferroptosis-induced cardiomyocyte loss is recognized as a novel contributor to myocardial remodeling in heart failure. Membrane...
Inflammatory Association between Periodontal Disease and Systemic Health [0.03%]
牙周病与系统健康之间的炎症关联机制研究进展
Fajer Hasan,Ankit Tandon,Hawra AlQallaf et al.
Fajer Hasan et al.
Periodontitis is an oral disease that affects almost half of the adult population in United States. The complex relationship between oral and systemic health has been the focus of extensive research, aiming to unravel the mechanisms linking...
WFS1 Gene Mutation (c.2389G > A) Induces Immune Disorders by Promoting DC Maturation through Inhibition of TMEM176A [0.03%]
WFS1基因(c.2389G>A)突变通过抑制TMEM176A促进DC成熟诱导免疫紊乱
Wei Lin,Yuanhui Qiu,Chenyinuo Tan et al.
Wei Lin et al.
Mutations in the WFS1 gene, encoding wolframin (WFS1), are known to cause endoplasmic reticulum (ER) stress and lead to Wolfram Syndrome (WS). However, the role of WFS1 in immune inflammation remains unexplored. In this study, we identified...