Nikolai Staier,Norbert Mair,Christoph Frisch et al.
Nikolai Staier et al.
In septic patients, oxygen delivery is often impaired, yet the specific impact of inflammation on erythrocyte oxygen transport characteristics remains largely unexplored. This study examined the direct effects of endotoxin-induced inflammat...
The Neuroprotective Effect of 4-Octyl Itaconate on Acute Period of Experimental Autoimmune Neuritis [0.03%]
4-辛基异丁酸对实验性自身免疫性神经炎急性期的神经保护作用
Lin-Jie Zhang,Ning Zhao,Jia Li et al.
Lin-Jie Zhang et al.
The current standard therapy for acute-phase Guillain-Barré syndrome (GBS) remains limited to intravenous immunoglobulin and plasma exchange. Developing novel pharmacological agents to halt acute disease progression represents a critical u...
Integrating Nutrition into Precision Medicine for Controlling Systemic Inflammation in Rheumatoid Arthritis [0.03%]
营养在精准医学中用于控制类风湿性关节炎全身炎症的整合研究
Francesca Ingegnoli,Saviana Gandolfo,Francesco Ciccia et al.
Francesca Ingegnoli et al.
The management of rheumatoid arthritis (RA) has evolved from the conventional “treat-to-target” approach to strategies that emphasize individualized, patient-centered care. Concepts such as “therapeutic matchmaking” and “smart-to-targe...
NOX2-Dependent Phagocyte Signaling Mediates Silica-Induced Murine Lung Injury via Macrophage-Neutrophil Interactions [0.03%]
NADPH氧化酶依赖的吞噬细胞信号通过巨噬细胞-中性粒细胞相互作用介导二氧化硅致小鼠肺损伤
Masahiro Kusaka,Koji Sakamoto,Yoshiki Ikeyama et al.
Masahiro Kusaka et al.
In phagocytes, reactive oxygen species produced by NADPH oxidase 2 (NOX2) play a crucial role in the digestion of phagocytosed material as well as in immune response signaling. We recently reported the role of NOX2 in regulating inflammator...
TREML2 Modulates Microglial Phagocytosis of Myelin Debris via TLR9 in Chronic Cerebral Ischemia [0.03%]
TREML2通过TLR9调节慢性脑缺血状态下小胶质细胞的髓鞘残渣吞噬作用
Zhao-Han Xu,Jing-Wen Qi,Xin-Yu He et al.
Zhao-Han Xu et al.
Demyelination is a significant pathological feature of chronic cerebral ischemia. Recent evidence suggested that microglia played a protective role in mitigating brain ischemic injury via phagocytosis of myelin debris resulting from demyeli...
Loss of the miR-221/222 Cluster Promotes the Pathogenesis of Osteoarthritis in Inflamed Mouse Chondrocytes and Osteoarthritis Models [0.03%]
miR-221/222簇的丢失促进炎症小鼠软骨细胞和骨关节炎模型中骨关节炎的发生发展
Xinlei Liu,Fangyu Feng,Yiman Jin et al.
Xinlei Liu et al.
Osteoarthritis (OA) is a degenerative joint disorder with the destruction of the joint's structural and functional which affects the entire joint. An important feature of OA is the progressive degeneration of articular cartilage due to an i...
Urine-Derived CD105-Positive Exosome Promotes Macrophage M1 Polarization Through the TGF-β1/Smad3 Signaling Axis To Exacerbate Lupus Nephritis [0.03%]
尿源性CD105阳性外泌体通过TGF-β1/Smad3信号轴促进M1型巨噬细胞极化以加重狼疮性肾炎
Yanmin Pang,Xiuhong Pan,Linlin He et al.
Yanmin Pang et al.
This study investigated the regulatory role of exosomal CD105 in macrophage polarization and its mechanisms in lupus nephritis (LN). Analysis of samples from 20 LN patients revealed significant CD105 overexpression in kidney tissues and uri...
HNRNPC-Mediated m6A Epitranscriptomics Drives CD80-Dependent Tubular Dysfunction in Sepsis-Induced AKI [0.03%]
HNRNPC介导的m6A表转录组学驱动脓毒症诱导的急性肾损伤中的CD80依赖性管腔功能障碍
Chenxia Juan,Xiangling Zhao,Yuejuan Wang et al.
Chenxia Juan et al.
Sepsis-associated acute kidney injury (S-AKI) is a critical condition characterized by renal tubular epithelial cell apoptosis and abnormal cytoskeleton. This study aims to investigate the role of the m6A modification-dependent protein HNRN...
Correction: Metformin Attenuates Partial Epithelial-Mesenchymal Transition in Salivary Gland Inflammation Via PI3K/Akt/GSK3β/Snail Signaling Axis [0.03%]
更正：二甲双胍通过PI3K/Akt/GSK3β/Snail信号轴在唾液腺炎中减弱部分上皮间质转化
Boyuan Peng,Lianhao Wang,Shijiao Pan et al.
Boyuan Peng et al.
Published Erratum
Inflammation. 2025 Oct 11. DOI:10.1007/s10753-025-02345-x 2025
Early α-Synuclein Pathology Induces Neuroinflammation and Decreases Topoisomerase IIβ Expression in A53T Mice [0.03%]
早期α-突触核蛋白病理改变诱发小鼠神经炎症并降低拓扑异构酶IIβ的表达
Berçem Yeman-Kıyak,Tahire Yurdakul,Aslınur Selim et al.
Berçem Yeman-Kıyak et al.
Neuroinflammation in the pathogenesis of neurodegenerative diseases is still a subject of discussion, as it might be either the cause or the result of neurodegeneration. Misfolded or improperly aggregated α-synuclein in Parkinson's Disease...