Single-Cell Transcriptome Analysis of the Retina During the Development of Normal Tension Glaucoma in Mice [0.03%]
单细胞转录组分析小鼠正常眼压青光病视网膜的改变
Xinna Liu,Di Zhang,Mengxian Du et al.
Xinna Liu et al.
Glaucoma is characterized by the progressive degeneration of retinal ganglion cells (RGCs), the pathogenesis of which is still unknown. Many studies have reported that retinal glial cells play an important role in neuron degeneration, but t...
Deacetylasperulosidic Acid Methyl Ester Ameliorates Carbon Tetrachloride-Induced Liver Fibrosis by Suppressing Inflammation and Modulating Gut Microbiota [0.03%]
脱乙酰基asperulosidic酸甲酯通过抑制炎症和调节肠道微生物群改善四氯化碳诱导的肝纤维化
Li Chen,Chunyan Chen,Qixiang Chen et al.
Li Chen et al.
Liver fibrosis is an excessive wound-healing response triggered by chronic liver injury. It may eventually progress to cirrhosis, liver failure or liver cancer. Currently, there are no effective therapeutic strategies available. Deacetylasp...
MIF Regulates the Th17/Treg Ratio to Exacerbate Kidney Injury in Chronic Kidney Disease [0.03%]
MIF通过调节Th17/Treg比例加重慢性肾脏病肾损伤
Ruijing Zhang,Keyi Fan,Heng Wang et al.
Ruijing Zhang et al.
Chronic kidney disease (CKD) is characterized by gradual and progressive deterioration of renal function over time, and its pathogenesis is strongly associated with immune cell imbalance, Th cell diversification, and oxidative stress. This ...
Neuroimmune Crosstalk in Psoriasis: Mechanisms and Therapeutic Implications [0.03%]
银屑病的神经免疫相互作用：机制及治疗意义
Hanlin Gao,Yi Fang,Yue Zhang et al.
Hanlin Gao et al.
Psoriasis is a chronic, immune-mediated inflammatory skin disorder characterized by keratinocyte hyperproliferation, dermal vascular remodeling, and dense immune cell infiltration. While the conventional immunopathological model emphasizes ...
The GATA3-STEAP4 Axis Drives Inflammation by Promoting Th2 Differentiation in Allergic Rhinitis [0.03%]
GATA3-STEAP4轴通过促进变应性鼻炎中Th2分化来促炎症反应
Xiaoxu Ding,Hui Su,Tiancong Liu et al.
Xiaoxu Ding et al.
Allergic rhinitis (AR) is an inflammatory disease of the upper airway that primarily affects the nasal mucosa, with Th2 differentiation-driven inflammation as a key contributor. A bioinformatics analysis of dataset GSE52804 identified Six-t...
Palmatine Attenuates Lipopolysaccharide-Induced Acute Lung Injury Via Suppression of NLRP3 Inflammasome Activation, Pyroptosis, and Metabolic Remodeling [0.03%]
棕亭胺通过抑制NLRP3炎性小体活化、细胞焦亡和代谢重塑治疗脂多糖诱导的急性肺损伤
Pu Ning,Jing Wu,Qiuyue Long et al.
Pu Ning et al.
Acute lung injury (ALI) is a critical condition characterized by uncontrolled inflammation, respiratory insufficiency, and tissue damage, often triggered by pneumonia or sepsis. Aberrant activation of the NOD-like receptor thermal protein d...
Intestinal LGR4 Signalling Alters Bacterial translocation, Intrahepatic Microbiota composition, and Type 1 Interferon Expression in Murine Liver Fibrosis [0.03%]
肠LGR4信号改变细菌移位、小鼠肝纤维化中的肝内菌群组成和I型干扰素表达
Junyan Gao,Bangtao Chen,Cheng Chen et al.
Junyan Gao et al.
Liver fibrosis (LF) is linked to decreased type 1 interferon (IFN1) levels at steady-state, intestinal dysbacteriosis, leaky gut, and intestinal bacterial translocation. Liver leucine-rich repeats containing G protein-coupled receptor 4 (LG...
Alpha-1 Antitrypsin Mediates Spontaneous Resolution of Acute Gouty Inflammation Via Inhibiting Caspase 3/GSDME-dependent Macrophage Pyroptosis [0.03%]
α-1抗胰蛋白酶通过抑制caspase 3/GSDME依赖的巨噬细胞焦亡介导急性痛风性炎症的自发消退
Xin Li,Lei Liu,Shuting Tong et al.
Xin Li et al.
Research on spontaneous resolution of acute gout remains limited. Macrophages pyroptosis is crucial for the inflammation of acute gout, while current research mainly focus on Caspase 1/Gasdermin D axis. We aimed to investigate the involveme...
Spermidine Alleviates Sepsis-Induced Acute Lung Injury through AMPK-Mediated Improvement of Necroptosis [0.03%]
spermidine通过AMPK介导的对坏死性凋亡的改善缓解了脓毒症引起的急性肺损伤
Bingqing Ye,Yuan Jin,Shansong Hu et al.
Bingqing Ye et al.
Sepsis, a life-threatening organ dysfunction caused by dysregulated host responses to infection, often leads to sepsis-associated acute lung injury (SALI), a major contributor to mortality. Spermidine (SPD), a natural polyamine with anti-in...
L-Carnitine Attenuates Testicular Dysfunction in Type 1 Diabetes Mellitus Via Modulation of Oxidative Stress, Inflammation, and miRNA Expression [0.03%]
左旋肉碱通过调节氧化应激、炎症和microRNA表达来缓解1型糖尿病的睾丸功能障碍
Hero Khalid Mustafa,Khder Hussein Rasul,Azheen Subhi Abdulrahman et al.
Hero Khalid Mustafa et al.
Type 1 diabetes mellitus (T1DM) is a significant global health concern, adversely affecting various metabolic pathways and organ systems, including male reproductive health. This study aimed to investigate the protective effects of L-carnit...