Inhibition of the JAK/STAT Signaling Pathway Suggests a Protective Effect against Acantholysis in Pemphigus [0.03%]
JAK/STAT信号传导路径的抑制作用对防止天疱疮中的棘松解具有保护作用
Farzan Solimani,Julia Holstein,Katharina Meier et al.
Farzan Solimani et al.
Pemphigus is a severe autoimmune blistering disorder of skin and mucosa, which is elicited by gG autoantibodies targeting desmosomal components such as desmoglein 3 (Dsg3). Keratinocytes lose cytoarchitectural stability and reciprocal adhes...
LncRNA SNHG1 Knockdown Ameliorates HIV-1 gp120V3 Loop-Induced Microglial Neuroinflammation by Regulating the Autophagy Process [0.03%]
lncRNA SNHG1 敲低通过调节自噬过程缓解HIV-1gp120 V3环诱导的小胶质细胞神经炎症
Xueqin Yan,Qin Zuo,Xinyi Li et al.
Xueqin Yan et al.
HIV-1-associated neurocognitive disorders (HAND) are characterized by chronic CNS inflammation. Previous studies have shown that HIV-1 gp120 causes learning and memory deficits in mice and neuroinflammation in neurons and microglia through ...
ZBP1 Mediates Renal Tubular Injury in Diabetic Nephropathy Through RIPK3-mediated Necroptosis [0.03%]
糖尿病肾病中ZBP1介导的RIPK3激活依赖性肾小管坏死样细胞死亡
Ziyun Hu,Yu Ma,Yukai Wang et al.
Ziyun Hu et al.
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease. Given the limited therapeutic options, identifying novel differentially expressed genes and therapeutic targets is crucial for DN. We performed transcriptome sequenc...
Autophagy-NLRP3 Inflammasome Crosstalk in Microglia: A Therapeutic Target for Multiple Sclerosis [0.03%]
小胶质细胞自噬-NLRP3炎性体互作在多发性硬化治疗中的作用与机制研究
Jie-Qiong Lu,Hui-Qi Wang,Ma-Rong Fang et al.
Jie-Qiong Lu et al.
SLC38A1 Inhibits Ferroptosis of Alveolar Type II Epithelial Cells in Acute Lung Injury by Promoting Autophagic Degradation of Divalent Metal Transporter 1 (DMT1): an In Vivo and In Vitro Study [0.03%]
SLC38A1通过促进二价金属转运蛋白1的自噬降解抑制急性肺损伤中II型肺泡上皮细胞铁死亡：体内和体外研究
Fan Su,Xiaopei Yan,Xinyan Li et al.
Fan Su et al.
Recent studies have highlighted the relationship between ferroptosis in type II alveolar epithelial cell (ATII cell) and acute lung injury (ALI). Solute carrier family 38 member 1 (SLC38A1) is a member of the SLC38 gene family, expressed in...
SYK Activation Enhances Dendritic Cell Functions in Spontaneous Rheumatoid Arthritis [0.03%]
SYK活化增强自发性类风湿关节炎的树突状细胞功能
Zhiyang Zeng,Xiya Cao,Haozhe Guo et al.
Zhiyang Zeng et al.
Higenamine Hydrochloride Ameliorates Diabetic Cardiomyopathy Through RhoA/MEK/ERK Pathway [0.03%]
盐酸海梗烷通过RhoA/MEK/ERK信号通路改善糖尿病心肌病
Ying Li,Lei Wang,Tianyue Guan et al.
Ying Li et al.
Caveolin-1 Regulates Ultrastructural Alterations of Astrocytes in Chronic Cerebral Hypoperfusion [0.03%]
Caveolin-1调节慢性脑低灌注的星形胶质细胞超微结构改变
Min Wu,Xiaohao Zhang,Di Wang et al.
Min Wu et al.
Cerebral white matter exhibits heightened susceptibility to chronic hypoperfusion. Increasing evidence implicates glial cells, notably astrocytes, in mediating chronic ischemic demyelination. To elucidate the involvement of astrocytes in is...
Lactate and H3K18 Lactylation Contribute To the Exacerbation of Acute Pancreatitis by Modulating NCOA4-mediated Ferroptosis [0.03%]
乳酸和H3K18乳酰化通过调节NCOA4介导的铁死亡加重急性胰腺炎
Zi-Yu Han,Xue-Ying Ma,Shi-Ya Ma et al.
Zi-Yu Han et al.
Infralimbic Cortex Microglial TREM-1 Mediates Neuroinflammation and Exacerbates Depressive-Like Behaviors in Parkinson's Disease Model Mice [0.03%]
帕金森病模型小鼠中 infralimbic 大脑海马小胶质细胞 TREM-1 介导的神经炎症加重抑郁样行为
Yuan-Qing Chu,Wei Song,Zhi-Jing Song et al.
Yuan-Qing Chu et al.
Depression is a common nonmotor feature of Parkinson's disease (PD) that severely compromises the quality of life of patients, yet its pathogenesis remains elusive. Triggering receptor expressed on myeloid cells 1 (TREM-1) is an immunoglobu...