Treg Cells Impair Talaromyces Marneffei Clearance by Promoting M2 Macrophage Polarization Via the IL-10/IL-10R/STAT3 Axis [0.03%]
调节性T细胞通过IL-10/IL-10R/STAT3轴促进M2型巨噬细胞极化从而抑制马尼菲青霉清除作用
Mengxin Tang,Zeng Wen,Feng Xin et al.
Mengxin Tang et al.
Talaromyces marneffei (TM) causes a deeply invasive fatal fungal disease in immunocompromised individuals that is widespread in Southeast Asia and southern China, and little is known about how this fungus can evade the human immune system. ...
rIL-22 Alleviates Severe Acute Pancreatitis and Secondary Multiple Organ Injury Induced by Caerulein in Mice [0.03%]
鼠尾蓝虾素诱导的急性重症胰腺炎中,rIL-22基因治疗减轻肺损伤及多器官衰竭
Hongli Yang,Weijia Sun,Peilin Cheng et al.
Hongli Yang et al.
Multiomics Integration Analysis Reveals the Regulatory Mechanisms of Efferocytosis in Diabetic Kidney Disease [0.03%]
多组学整合分析揭示糖尿病肾脏病胞葬作用的调控机制
Yi Kang,Qian Jin,Mengqi Zhou et al.
Yi Kang et al.
Diabetic kidney disease (DKD) is a prevalent complication in individuals with diabetes. Efferocytosis plays a pivotal role in chronic diseases; however, the precise mechanisms involved in DKD are still not fully understood. DKD-related data...
Fisetin Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Targeting Myeloid Differentiation Factor 88 [0.03%]
山奈酚通过靶向髓系分化簇88减轻脂多糖诱导的急性肺损伤
Zhongqian Jin,Xin Liu,Zhuohui Xie et al.
Zhongqian Jin et al.
Acute lung injury (ALI), a severe respiratory syndrome driven by dysregulated inflammatory cascades, urgently requires novel therapeutic strategies. The activation of the MyD88 (Myeloid differentiation factor 88)-mediated TLR (Toll-like rec...
TSG-6 Activated MSC-derived Extracellular Vesicles Present Altered micro-RNA Contents and Ameliorate the Inflammatory Phenotype of Macrophages in Vitro [0.03%]
TSG-6激活的MSC源性外泌体携带不同的microRNA并在体外改变巨噬细胞的表型
Iker Martinez-Zalbidea,Alyssa Rzasa,Varun Puvanesarajah et al.
Iker Martinez-Zalbidea et al.
Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have shown promising immunomodulatory properties; however, strategies to enhance their therapeutic potential remain limited. Here, we employed CRISPR activation of the gene TSG-...
HSP60 Mediates NLRP3 Inflammasome-Dependent Microglial Pyroptosis Via the TLR4/MyD88/NF-κB Signaling Axis After Subarachnoid Hemorrhage [0.03%]
热休克蛋白60通过TLR4/MyD88/NF-κB信号轴介导蛛网膜下腔出血后NLRP3炎症小体依赖的微胶质细胞焦亡
Zheng-Qing Hu,Ruijie Ma,Hang Zhang et al.
Zheng-Qing Hu et al.
This study aims to elucidate the mechanism by which Heat Shock Protein 60 (HSP60) mediates microglial pyroptosis in the context of early brain injury (EBI) following subarachnoid hemorrhage (SAH), and to investigate the effects of HSP60 inh...
Comparative Analysis of Hypothalamic Responses to Stress and Glutamine Supplementation in Diet-Induced Obese Mice: A Study of Sex Differences [0.03%]
饮食诱导的肥胖小鼠下丘脑应激和谷氨酰胺补充反应的比较分析：性别差异研究
Virginie Dreux,Candice Lefebvre,Charles-Edward Breemeersch et al.
Virginie Dreux et al.
Hypothalamic inflammation plays a key pathophysiological mechanism linking chronic consumption of a high fat diet (HFD) to the development of obesity and associated metabolic complications. Pilot studies report that oral glutamine (Gln) sup...
Intestinal Sclerostin Deficiency Links Gut Dysbiosis to Altered Serotonin Homeostasis in Axial Spondyloarthritis [0.03%]
肠道硬化素缺乏症将轴向脊柱关节炎的肠道菌群紊乱与5-羟色胺稳态改变联系起来
Daniele Mauro,Anne-Sophie Bergot,Giuliana Guggino et al.
Daniele Mauro et al.
Background: Sclerostin regulates bone formation via Wnt/β-catenin signaling inhibition and contributes to intestinal epithelial homeostasis. Circulating sclerostin levels are reduced in axial spondyloarthritis (axSpA) an...
Programmed death-ligand 1 (PD-L1) Modulates Chemokine Production Via the TLR4/TRAF6 Signaling Axis During LPS + IFN-γ-Induced Endotoxemia-mimicked Sepsis [0.03%]
程序性死亡配体1(PD-L1)通过TLR4/TRAF6信号轴调节脂多糖+干扰素-γ诱导的内毒素血症型脓毒症中的细胞因子和趋化因子产生
Mu Yuan,Tong Jin,Luoquan Ao et al.
Mu Yuan et al.
As a pivotal immune checkpoint molecule, programmed death-ligand 1 (PD-L1) is anchored primarily on the membrane surface of immune cells, where it exerts immunosuppressive effects, thereby facilitating tumor immune evasion. Macrophages, whi...
HDAC3 Mediates Hippocampal Microglial Pyroptosis Via the STING/NLRP3 Pathway and Contributes To Cognitive Impairment in Sepsis-Associated Encephalopathy [0.03%]
组蛋白脱乙酰酶3介导脓毒症相关性脑病海马小胶质细胞STING/NLRP3依赖的炎性焦亡并参与认知功能障碍
Meng Cai,Hua Shao,Shan Xu et al.
Meng Cai et al.
Microglial pyroptosis-mediated neuroinflammation emerges as a critical pathogenic mechanism underlying sepsis-associated encephalopathy (SAE). Epigenetic modifications, especially histone acetylation states, exert fundamental regulatory eff...