NMI as a Novel pro-inflammatory Driver in Acute Pancreatitis Via PI3K-AKT Mediated Macrophage Activation [0.03%]
NMI通过PI3K-AKT介导的巨噬细胞活化在急性胰腺炎中成为一种新的促炎症驱动因素
Xiaoran Guo,Zhenting Liu,Zhuangfeng Weng et al.
Xiaoran Guo et al.
Acute pancreatitis (AP) is an inflammatory disorder that escalate rapidly from localized pancreatic injury to systemic inflammation and multi-organ failure. Dysregulated innate immunity is central to AP pathogenesis: acinar cell injury rele...
Caveolin-2 Knockdown Alleviated Sepsis-induced Acute Lung Injury Via Promoting Macrophage M2 Polarization and Inhibiting Apoptosis by Hippo Signaling Pathway [0.03%]
Caveolin-2敲低通过促进巨噬细胞M2极化和抑制Hippo信号通路介导的凋亡缓解内毒素致急性肺损伤的作用及机制研究
Xiang Xue,Fei Gao,Juan Chen et al.
Xiang Xue et al.
Sepsis-induced acute lung injury is a significant clinical challenge with high morbidity and mortality rates. Currently, no effective therapeutic interventions are available. The aim of this study was to elucidate the role and underlying me...
miR-221 Exerts Antiviral and Anti-Inflammatory Effects against HSV-1 Through Direct Repression of CAMK2A and Immune Pathway Activation [0.03%]
微RNA-221通过直接抑制CAMK2A和激活免疫途径发挥抗HSV-1的病毒和抗炎作用
Jiahao Xu,Lianhong Xu,Die Hu et al.
Jiahao Xu et al.
Herpes simplex virus type 1 (HSV-1) triggers significant inflammation and immune dysregulation, particularly in immunocompromised hosts. MicroRNA-221 (miR-221) is implicated in viral pathogenesis and inflammatory responses, yet its role in ...
INPP5D Upregulation by Minocycline Mitigates Sepsis-Associated Neuroinflammation and Neuronal Dysfunction Via Microglial Autophagy and Antioxidant Pathways [0.03%]
米诺环素通过小胶质细胞自噬和抗氧化途径上调INPP5D减轻脓毒症相关神经炎症和神经元功能障碍
Yu-Jing Li,Xiu Zhang,Jing-Nan Fu et al.
Yu-Jing Li et al.
Sepsis-associated neuroinflammation contributes to long-term neurological deficits, but therapeutic strategies remain limited. Here, we demonstrate that minocycline (Mino) mitigates sepsis-induced neuroinjury by upregulating inositol polyph...
Luteolin Attenuates Asthma Via Inhibiting ALOX15 Mediated Bronchial Epithelial Cell Ferroptosis [0.03%]
黄芩素通过抑制ALOX15介导的支气管上皮细胞铁死亡来缓解哮喘症状
Kangdi Liu,Wenjian Wang,Tanxuan Huang et al.
Kangdi Liu et al.
Ferroptosis, an iron-dependent form of cell death driven by lipid peroxidation, plays a critical role in the progression of asthma, yet its therapeutic modulation remains underexplored. Luteolin (Lut), a natural flavonoid known for its anti...
Mengxia Shi,Shulin Ma,Qi An et al.
Mengxia Shi et al.
Lupus nephritis (LN), a severe manifestation of systemic lupus erythematosus, involves immune complex deposition, inflammation, and kidney damage. Recent studies indicate that pyroptosis, a pro-inflammatory cell death process, drives renal ...
A Novel YTHDF2/SIGMAR1 Axis in Astrocytes Regulates Neuroinflammation and Cognitive Impairment in Diabetic Encephalopathy [0.03%]
糖尿病性脑病小胶质细胞活化和认知障碍的新机制YTHDF2/SIGMAR1轴调控研究
Feng Xu,Hao Zhang,Xiaohong Chen et al.
Feng Xu et al.
Diabetic encephalopathy (DE), a severe complication of diabetes, is characterized by cognitive decline and neuroinflammation, in which astrocytes play a critical role. YTHDF2, an m6A reader protein, has been implicated in regulating inflamm...
Narciclasine Alleviates Endothelial Inflammation and Atherosclerosis Initiation by Inhibiting Histone Lactylation-Mediated NF-κB Activation [0.03%]
纳曲康碱通过抑制组蛋白乳酰化介导的NF-κB活化来缓解内皮炎症和动脉粥样硬化发生
Ziqian Wang,Zhengbin Zhang,Ran Xin et al.
Ziqian Wang et al.
Glycolysis-derived lactate serves as a substrate for lysine lactylation, an epigenetic modification playing critical transcriptional regulatory roles in inflammatory diseases. Endothelial inflammation, characterized by upregulated glycolysi...
Activation of β2-Adrenergic Receptor Alleviates Viral Myocarditis by Regulating Energy Metabolism in Monocyte-derived Macrophages via the AMPK Pathway [0.03%]
β2肾上腺素受体通过AMPK信号通路调节单核细胞源性巨噬细胞能量代谢从而缓解病毒性心肌炎
Quan-Liang Li,Ying-Xin Guo,Juan-Fen Li et al.
Quan-Liang Li et al.
Acute viral myocarditis (AVM) is a leading cause of sudden cardiac death in young individuals, and currently, there are no effective targeted clinical treatments. The role and underlying mechanisms of β2-adrenergic receptors (β2-AR) in th...
Impaired Mitophagy-Induced Apoptosis of Gingival Fibroblasts Exacerbates Diabetic Periodontitis Via THBS-1/CD36-Dependent Macrophage Activation [0.03%]
线粒体自噬诱导的牙龈成纤维细胞凋亡通过THBS-1/CD36依赖性巨噬细胞活化加重糖尿病型牙周炎
Rundong Yuan,Lingxiao Meng,Minglei Zhang et al.
Rundong Yuan et al.
Diabetic periodontitis (DPD) is a severe inflammatory complication characterized by accelerated destruction of periodontal tissues and dysregulated immune responses. Gingival fibroblast (GF)-macrophage interactions drive DPD progression, bu...