Single-Cell Transcriptomic Characterization of DNCB-Induced Mouse Model Reveals Atopic Dermatitis-Associated Skin Lesions in Skin Microenvironment [0.03%]
单细胞转录组揭示12-O-十四烷磷酰佛波醇-13-乙酸酯诱导小鼠模型皮肤微环境中的特应性皮炎相关皮肤病变
Wenxiang Liu,Zhuoya Qiu,Jialei Fu et al.
Wenxiang Liu et al.
Aberrant Accumulation of Cell-Free DNA Activates the cGAS-STING-TBK1 Pathway of γδ T Cells to Promote the Inflammatory Responses in Oral Lichen Planus [0.03%]
细胞外游离DNA通过激活γδT细胞的cGAS-STING-TBK1信号通路促进口腔扁平苔藓炎症反应
Xin-Yi Wei,Ya-Qin Tan,Gang Zhou
Xin-Yi Wei
Oral lichen planus (OLP) is a chronic T-cell-mediated immune inflammatory disease with unclear etiology. γδ T cells are crucial for regulating T-cell activity and immune inflammatory responses. The cGAS-STING-TBK1 pathway serves as an imm...
The Transcription Factor DDIT3 Regulates Macrophage Function by Inhibiting KLF10 to Attenuate ALI/ARDS Inflammation [0.03%]
转录因子DDIT3通过抑制KLF10减轻ALI/ARDS炎症来调节巨噬细胞功能
Mengfei Sun,Qianqian Yang,Yingshuai Tan et al.
Mengfei Sun et al.
Vascular Non-Inflammatory Molecule-1 Aggravates Acute Kidney Injury Induced Acute Lung Injury Via Promoting Neutrophil Extracellular Traps Formation [0.03%]
血管非炎症分子-1通过促进中性粒细胞胞外诱捕网形成加重急性肾损伤诱导的急性肺损伤
Chang Liu,Yan Yang,Yi Song et al.
Chang Liu et al.
Acute kidney injury-induced acute lung injury (AKI-ALI) is a severe clinical syndrome characterized by systemic inflammation, oxidative stress, and immune cell activation. Vascular non-inflammatory molecule-1 (Vanin-1, VNN1), a pantetheinas...
Bifidobacterium Infantis Promotes FOSL1-Mediated Transcriptional Repression of VDR to Accelerate Autoimmune Pancreatitis Progression Through Activation of Oxidative Stress [0.03%]
双歧杆菌婴儿型通过激活氧化应激促进FOSL1介导的VDR转录抑制以加速自身免疫性胰腺炎的发展
Jie Tang,Qin Li,Kai Li et al.
Jie Tang et al.
Integrated Transcriptomic Analysis Identifies TAP1 as a Key Regulator of PANoptosis in Diabetic Kidney Disease Tubular Injury [0.03%]
整合转录组分析鉴定TAP1为糖尿病肾脏疾病管状损伤中PANoptosis的关键调节因子
Qingsong Chen,Hongxuan He,Gang Wang et al.
Qingsong Chen et al.
A Melittin-Derived Lead Compound Ameliorates Severe Acute Pancreatitis by Restoring Oxidative Homeostasis and Macrophage Metabolism [0.03%]
一种蜂毒派生的先导化合物通过恢复氧化平衡和巨噬细胞代谢来改善急性重症胰腺炎
Xiaolong Chen,Ya Chen,Yunyun Mao et al.
Xiaolong Chen et al.
Severe acute pancreatitis (SAP) is a life-threatening inflammatory condition driven by macrophage-mediated oxidative stress and metabolic dysregulation. While bioactive peptides such as melittin show anti-inflammatory potential, their clini...
GTS-21 Alleviates Acute Lung Injury by Enhancing GLP-1 Secretion and Regulating Alveolar Surfactant Proteins via α7nAChR Activation [0.03%]
通过激活α7nAChR增强GLP-1分泌和调节肺泡表面活性蛋白治疗急性肺损伤
Chunli Liu,Yuqi Song,Xinghan Tian et al.
Chunli Liu et al.
Zhenzong Fa,Zeping Huang,Yi Shang et al.
Zhenzong Fa et al.
Despite the well-recognized role of the deubiquitinase CYLD in the pathogenesis of tumors and certain inflammatory diseases, its specific function and regulatory mechanisms in psoriasis remain unclear. Thus, we first analyzed CYLD expressio...
Interleukin-33 Promotes Neutrophil Extracellular Trap Formation To Aggravate Renal Ischemia-Reperfusion Injury Through ST2/PI3K/Akt and ST2/PAD4 Pathways [0.03%]
白细胞介素33通过ST2/PI3K/Akt和ST2/PAD4信号通路促进中性粒细胞胞外陷阱形成加重肾脏缺血再灌注损伤
Feilong Zhang,Jiyue Wu,Zhen Li et al.
Feilong Zhang et al.
Renal ischemia-reperfusion injury (IRI) triggers a sterile immune response, primarily mediated by the innate immune system. Interleukin-33 (IL-33) promotes neutrophil infiltration during inflammatory processes, and neutrophils play a critic...