Glycyrrhizic Acid Alleviates Lipopolysaccharide (LPS)-Induced Acute Lung Injury by Regulating Angiotensin-Converting Enzyme-2 (ACE2) and Caveolin-1 Signaling Pathway [0.03%]
甘草酸通过调节血管紧张素转换酶-2和 caveolin-1信号通路缓解脂多糖诱导的急性肺损伤作用机制研究
Yangye Chen,Lihua Qu,Yi Li et al.
Yangye Chen et al.
Acute lung injury (ALI) is mainly caused by severe infection, shock, trauma, and burn, which causes the extensive release of inflammatory factors and other mediators. As a major bioactive constituent of traditional Chinese herb licorice, gl...
Propofol Downregulates lncRNA MALAT1 to Alleviate Cerebral Ischemia-Reperfusion Injury [0.03%]
丙泊酚通过下调MALAT1长链非编码RNA缓解脑缺血再灌注损伤
Yubo Hu,Cong Ye,Shuang Cheng et al.
Yubo Hu et al.
Propofol (PPF) is reported to play a protective role in ischemia/reperfusion (I/R) injury, including cerebral ischemia-reperfusion injury (CIRI). This study aims to investigate the mechanism by which PPF ameliorates CIRI. Kunming mice were ...
Paeoniflorin Suppresses Rheumatoid Arthritis Development via Modulating the Circ-FAM120A/miR-671-5p/MDM4 Axis [0.03%]
芍药苷通过调控环状FAM120A/miR-671-5p/MDM4轴抑制类风湿关节炎的发展
Junfu Ma,Qingliang Meng,Junping Zhan et al.
Junfu Ma et al.
Paeoniflorin is an active ingredient derived from Paeonia, which has an anti-inflammatory effect. However, the potential role and basis of paeoniflorin in rheumatoid arthritis (RA) are indistinct. Cell viability, cycle distribution, migrati...
ATN-161 Ameliorates Ischemia/Reperfusion-induced Oxidative Stress, Fibro-inflammation, Mitochondrial damage, and Apoptosis-mediated Tight Junction Disruption in bEnd.3 Cells [0.03%]
ATN-161改善bEnd.3细胞中缺血/再灌注诱导的氧化应激、成纤维炎性反应、线粒体损伤和凋亡介导的紧密连接破坏
Narayanappa Amruta,Gregory Bix
Narayanappa Amruta
We have previously demonstrated the significance of endothelial cell-expressed α5β1 integrin in ischemic stroke, having shown that α5β1 integrin endothelial cell-selective knockout mice are significantly resistance to ischemic stroke in...
Anti-angiogenic Properties of Bevacizumab Improve Respiratory System Inflammation in Ovalbumin-Induced Rat Model of Asthma [0.03%]
贝伐单抗的抗血管生成性能可改善卵清蛋白诱导的大鼠哮喘模型的呼吸系统炎症
Seyed Mohammadreza Bolandi,Zohreh Abdolmaleki,Mohammad-Ali Assarehzadegan
Seyed Mohammadreza Bolandi
Studies on the bronchial vascular bed have revealed that the number of blood vessels in the lamina propria and under the mucosa of the lung tissue increases in patients suffering from mild to severe asthma. Thus, in this study, a new strate...
Roles of Simvastatin and Sildenafil in Modulation of Cranial Irradiation-Induced Bystander Multiple Organs Injury in Rats [0.03%]
辛伐他汀和西地那非在调血脂和改善大鼠颅内照射旁效应损伤多器官中的作用研究
Engy Refaat Rashed,Mohamed Khairy Abdel-Rafei,Noura Magdy Thabet
Engy Refaat Rashed
In radiobiology and radiation oncology fields, the observation of a phenomenon called radiation-induced bystander effect (RIBE) has introduced the prospect of remotely located tissues' affection. This phenomenon has been broadly developed t...
Spinal Cord Injury Increases Pro-inflammatory Cytokine Expression in Kidney at Acute and Sub-chronic Stages [0.03%]
脊髓损伤急性期和次急期内引起肾脏促炎症细胞因子表达增加
Shangrila Parvin,Clintoria R Williams,Simone A Jarrett et al.
Shangrila Parvin et al.
Accumulating evidence supports that spinal cord injury (SCI) produces robust inflammatory plasticity. We previously showed that the pro-inflammatory cytokine tumor necrosis factor (TNF)α is increased in the spinal cord after SCI. SCI also ...
Zerva Ioanna,Bakela Katerina,Athanassakis Irene
Zerva Ioanna
Lipopolysaccharide (LPS) is commonly used in murine sepsis models, which are largely associated with immunosuppression and collapse of the immune system. After adapting the LPS treatment to the needs of locally bred BALB/c mice, the present...
Ropivacaine Induces Cell Cycle Arrest in the G0/G1 Phase and Apoptosis of PC12 Cells via Inhibiting Mitochondrial STAT3 Translocation [0.03%]
罗哌卡因通过抑制STAT3向线粒体转位诱导PC12细胞G0/G1期阻滞和凋亡
Lian Zeng,Aohan Li,Zhen Zhang et al.
Lian Zeng et al.
STAT3 has neuroprotective effect via non-canonical activation and mitochondrial translocation, but its effect on ropivacaine-induced neurotoxicity remains unclear. Our previous study revealed that apoptosis was an important mechanism of rop...
Thymosin β4 Suppresses LPS-Induced Murine Lung Fibrosis by Attenuating Oxidative Injury and Alleviating Inflammation [0.03%]
胸腺素β4通过减轻氧化损伤和炎症抑制脂多糖诱导的肺纤维化
Zhen Tian,Naijuan Yao,Fei Wang et al.
Zhen Tian et al.
Inflammation plays a critical role in the progression of pulmonary fibrosis. Thymosin β4 (Tβ4) has antioxidant, anti-inflammatory, and antifibrotic effects. Although the potent protective role of Tβ4 in bleomycin-induced pulmonary fibros...