Non-apoptotic Regulated Cell Death Mechanisms in Sepsis and their Therapeutic Potential [0.03%]
脓毒症中非凋亡的调节性细胞死亡机制及其治疗潜力
Andrei Otto Mitre,Maria-Adriana Neag,Ioana Baldea et al.
Andrei Otto Mitre et al.
Simvastatin Alleviates ConA-Induced Autoimmune Hepatitis by Inhibiting CD4+ T Cell Activation via Calcium-NFATC3 Pathway [0.03%]
辛伐他汀通过钙-NFATC3信号通路抑制CD4⁺T细胞活化缓解ConA诱导的自身免疫性肝炎
Xiyu Wang,Tianhang Long,Longyang Zhou et al.
Xiyu Wang et al.
Although simvastatin plays a crucial role in lipid management, tumor therapy and acute liver injury, its potential effects in autoimmune hepatitis (AIH) has received limited investigative attention. Our study demonstrated that in the ConA-i...
Inhibition of TRPV4 Regulates Mitophagy Through the Sirt1/FoxO1 Signaling Pathway To Alleviate Acute Lung Injury [0.03%]
TRPV4抑制通过Sirt1/FoxO1信号通路调节线粒体自噬以缓解急性肺损伤
Xiuyun Wu,Shasha Liu,Qin Zhao et al.
Xiuyun Wu et al.
The transient receptor potential vanilloid 4 (TRPV4) channel has emerged as a key mediator of calcium dysregulation in acute lung injury (ALI), but its role in mitophagy-the selective autophagic clearance of dysfunctional mitochondria-and c...
Anti-Inflammatory and Protective Role of tiRNA-Glu-TTC-003 in Pediatric Sepsis Via TREM2/TLR4 Signaling Modulation [0.03%]
通过调节TREM2 / TLR4信号传导在儿童脓毒症中发挥抗炎和保护作用的tiRNA-Glu-TTC-003
Chenfang Zeng,Lihong Wu,Liying Zou et al.
Chenfang Zeng et al.
Sepsis, a severe infection, often leads to an overwhelming inflammatory response. Transfer RNA (tRNA)-derived small RNAs (tsRNAs), a emerging type of small RNAs, is crucial in various biological activities. Nevertheless, the connection betw...
Clec7a Drives Microglial Activation-Mediated Myelin Degradation in Sepsis-Associated Encephalopathy [0.03%]
Clec7a介导脓毒症相关性脑病中小胶质细胞激活引起的髓鞘损伤
Jia-Xiong Jian,Xiao-Yu Yin,Xu-Dong Mei et al.
Jia-Xiong Jian et al.
Sepsis-associated encephalopathy (SAE) is a frequent and devastating central nervous system complication of sepsis and portends a poor prognosis. Accumulating data implicate C-type lectin domain family 7 member A (Clec7a) in neuroinflammati...
Targeting Thioredoxin Reductase 1 Alleviates Severe Acute Pancreatitis by Modulating Oxidative Stress and Ferroptosis-Related Pathways [0.03%]
靶向硫氧还蛋白还原酶1通过调节氧化应激和铁死亡相关途径缓解急性重症胰腺炎
Ze-Peng Shen,Lin Liu,Jie Yang et al.
Ze-Peng Shen et al.
Severe acute pancreatitis (SAP) is a life-threatening inflammatory disease characterized by pancreatic injury, systemic inflammatory responses, and multiorgan dysfunction. Oxidative stress is a central driver of SAP pathogenesis; however, e...
MALT1 Knockdown Alleviates Multiorgan Injury and Inflammation Through Inhibiting TAK1/NF-κB Signaling Pathway-Mediated T-Helper 1 and 17 Differentiations in LPS-induced Inflammation [0.03%]
MALT1敲低通过抑制TAK1/NF-κB信号通路介导的Th1和Th17分化来缓解LPS诱导的多器官损伤和炎症
Qinghe Huang,Yan Luo,Qinggui Chen et al.
Qinghe Huang et al.
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) is a vital regulator of inflammation and innate immune response. The aim of this study was to evaluate the potential of MALT1 knockdown for attenuating lipopolysacch...
Emil Bečka,Letícia Hudecová,Michal Pastorek
Emil Bečka
Neutrophil extracellular traps (NETs) represent a critical immune defense mechanism that can become pathological in sterile inflammation. Mitochondrial damage-associated molecular patterns (mtDAMPs) emerge as particularly potent triggers of...
Correction: Palmatine Attenuates Lipopolysaccharide-Induced Acute Lung Injury Via Suppression of NLRP3 Inflammasome Activation, Pyroptosis, and Metabolic Remodeling [0.03%]
番木鳖碱通过抑制NLRP3炎性小体活化、细胞焦亡和代谢重塑治疗脂多糖诱导的急性肺损伤的再修正通知公告
Pu Ning,Jing Wu,Qiuyue Long et al.
Pu Ning et al.
Published Erratum
Inflammation. 2026 Jan 27;49(1):35. DOI:10.1007/s10753-026-02465-y 2026
Piezo1 Regulates ZnT1-Mediated Zinc Homeostasis in Ulcerative Colitis [0.03%]
Piezo1调节溃疡性结肠炎中的ZnT1介导的锌稳态
Weizhen Xiang,Xiaoyuan Ge,Luyao Gao et al.
Weizhen Xiang et al.