Base flipping mechanism and binding strength of methyl-damaged DNA during the interaction with AGT [0.03%]
甲基损伤DNA与AGT相互作用过程中的碱基翻转机制及其结合强度
Rajendra Prasad Koirala,Narayan Prasad Adhikari
Rajendra Prasad Koirala
Methyl damage to DNA bases is common in the cell nucleus. O6-alkylguanine-DNA alkyl transferase (AGT) may be a promising candidate for direct damage reversal in methylated DNA (mDNA) at the O6 point of the guanine. Indeed, atomic-level inve...
Generic algebraic conditions for the occurrence of switch-like behavior of a chemical kinetic system of the hypoxia pathway [0.03%]
化学动力学系统中出现开关行为的通用代数条件——以缺氧途径为例
Quentin Vanhaelen
Quentin Vanhaelen
Weakly reversible chemical reaction networks with zero deficiency associated with mass-action kinetics admit, within each positive stoichiometric compatibility class, one positive steady state which is locally asymptotically stable and this...
Structural insights into the pathogenicity of point mutations in human acyl-CoA dehydrogenase homotetramers [0.03%]
人类酰基辅酶a脱氢酶同四聚体点突变致病性的结构见解
Homa Faraji,Azadeh Ebrahim-Habibi
Homa Faraji
Acyl-CoA dehydrogenase deficiency (ACAD) is an inherited and potentially fatal disorder with variable clinical symptoms. The relationship between pathogenicity and deleterious point mutations is investigated here in ACAD structures of short...
Joydeb Mukherjee,Deepa Chaturvedi,Shlok Mishra et al.
Joydeb Mukherjee et al.
Fluid flow at the microscale level exhibits a unique phenomenon that can be explored to fabricate microfluidic devices integrated with components that can perform various biological functions. In this manuscript, the importance of physics f...
Ion currents through the voltage sensor domain of distinct families of proteins [0.03%]
不同蛋白质家族电压传感器结构域中的离子电流
César Arcos-Hernández,Takuya Nishigaki
César Arcos-Hernández
The membrane potential of a cell (Vm) regulates several physiological processes. The voltage sensor domain (VSD) is a region that confers voltage sensitivity to different types of transmembrane proteins such as the following: voltage-gated ...
High order sliding mode control for restoration of a population of predators in a Lotka-Volterra system [0.03%]
基于高阶滑模控制的Lotka-Volterra系统中捕食者种群恢复方法研究
Jesica A Escobar,Ana Gabriela Gallardo-Hernandez,Marcos Angel Gonzalez-Olvera et al.
Jesica A Escobar et al.
Human-induced extinction and rapid ecological changes require the development of techniques that can help avoid extinction of endangered species. The most used strategy to avoid extinction is reintroduction of the endangered species, but on...
Impact of noise on the instability of spiral waves in stochastic 2D mathematical models of human atrial fibrillation [0.03%]
噪声对二维数学模型中螺旋波不稳定性的影响及作用机制研究（以人类房颤为例）
Euijun Song
Euijun Song
Sustained spiral waves, also known as rotors, are pivotal mechanisms in persistent atrial fibrillation (AF). Stochasticity is inevitable in nonlinear biological systems such as the heart; however, it is unclear how noise affects the instabi...
Synchronization in STDP-driven memristive neural networks with time-varying topology [0.03%]
基于STDP的时变拓扑忆阻神经网络同步分析与设计
Marius E Yamakou,Mathieu Desroches,Serafim Rodrigues
Marius E Yamakou
Synchronization is a widespread phenomenon in the brain. Despite numerous studies, the specific parameter configurations of the synaptic network structure and learning rules needed to achieve robust and enduring synchronization in neurons d...
Suppression of beta oscillations by delayed feedback in a cortex-basal ganglia-thalamus-pedunculopontine nucleus neural loop model [0.03%]
延迟反馈抑制皮层-纹状体-丘脑-中脑回路模型的β振荡
Yuqin Sun,Jiali Lü,Ye Zhou et al.
Yuqin Sun et al.
Excessive neural synchronization of neural populations in the beta (β) frequency range (12-35 Hz) is intimately related to the symptoms of hypokinesia in Parkinson's disease (PD). Studies have shown that delayed feedback stimulation strate...
Thermal transport across membranes and the Kapitza length from photothermal microscopy [0.03%]
基于光热显微镜的膜界面热传导与卡皮察长度问题研究
Panagis D Samolis,Michelle Y Sander,Mi K Hong et al.
Panagis D Samolis et al.
An analytical model is presented for light scattering associated with heat transport near a cell membrane that divides a complex system into two topologically distinct half-spaces. Our analysis is motivated by experiments on vibrational pho...