Bispecific anti-CD3 x anti-B7-H3 antibody mediates T cell cytotoxic ability to human melanoma in vitro and in vivo [0.03%]
双特异性抗CD3 x抗B7-H3抗体介导T细胞的细胞毒性作用以用于体外和体内的人类黑色素瘤治疗
Juan Ma,Tengfei Shang,Pan Ma et al.
Juan Ma et al.
Inhibition of the B7-H3 immune checkpoint is reported to limit the tumor growth of B7-H3+ tumors. In this study, we demonstrated B7-H3 expression in human melanoma cells, including a primary culture and several cell lines. Furthermore, we i...
The influence of prior ramucirumab treatment on the clinical activity of FOLFIRI as third-line therapy in patients with metastatic gastric Cancer [0.03%]
雷莫卢单抗前期治疗对转移性胃癌患者FOLFIRI三线治疗临床疗效的影响
Giandomenico Roviello,Roberto Petrioli,Pietro Rosellini et al.
Giandomenico Roviello et al.
Purpose Few data described the activity of chemotherapy after ramucirumab plus paclitaxel progression in metastatic gastric cancer patients. The aim of this phase II study is to assess the efficacy and safety of the FOLFIRI regimen as a thi...
Nifuroxazide induces apoptosis, inhibits cell migration and invasion in osteosarcoma [0.03%]
尼氟唑啶诱导骨肉瘤细胞凋亡并抑制其迁移和侵袭能力
Yi Luo,Anqi Zeng,Aiping Fang et al.
Yi Luo et al.
Osteosarcoma is the most common primary malignancy of bone and characterized by an appendicular primary tumor with a high rate of metastasis to the lungs. Unfortunately, there is no effective strategy to treat osteosarcoma in current clinic...
The antitumor efficacy of monomeric disintegrin obtustatin in S-180 sarcoma mouse model [0.03%]
环状atrostin-1抗肿瘤作用研究
Narine Ghazaryan,Naira Movsisyan,Joana Catarina Macedo et al.
Narine Ghazaryan et al.
Obtustatin, isolated from the Levantine Viper snake venom (Macrovipera lebetina obtusa -MLO), is the shortest known monomeric disintegrin shown to specifically inhibit the binding of the α1β1 integrin to collagen IV. Its oncostatic effect...
In vitro and in vivo cytotoxic activity and human serum albumin interaction for a methoxy-styryl-thiosemicarbazone [0.03%]
甲氧基茋噻二胺的体内外细胞毒活性及与人血清白蛋白相互作用研究
Otávio Augusto Chaves,Isabela S de Castro,Carla Marins Goulart et al.
Otávio Augusto Chaves et al.
Thiosemicarbazone is a class of compounds with potential applications in medicine, presenting high capacity to inhibit the growth of cancer cells as well as low toxicity. Because of high interest in anticancer studies involving thiosemicarb...
The cellular effects of novel triazine nitrogen mustards in glioblastoma LBC3, LN-18 and LN-229 cell lines [0.03%]
三嗪氮芥类化合物对胶质母细胞瘤LBC3、LN-18和LN-229细胞系的细胞效应
Rafał Krętowski,Danuta Drozdowska,Beata Kolesińska et al.
Rafał Krętowski et al.
1,3,5-triazine is an important heterocyclic skeleton for mono, two or three 2-chloroethylamine groups. The study presented here provides novel information on cellular effects of 1,3,5-triazine with mono, two or three 2-chloroethylamine grou...
The rhenium(I)-diselenoether anticancer drug targets ROS, TGF-β1, VEGF-A, and IGF-1 in an in vitro experimental model of triple-negative breast cancers [0.03%]
雷尼酸用于三阴性乳腺癌体外模型：靶向ROS，TGF-β1，VEGF-A和IGF-1
Philippe Collery,Vijay Veena,Adhikesavan Harikrishnan et al.
Philippe Collery et al.
The rhenium(I)-diselenoether complex (Re-diSe) is a rhenium tricarbonyl-based drug chelated by a diselenoether ligand. In this work, we compared its inhibitory effects on the hormone-independent MDA-MB231cancer line and other different canc...
Inhibition of AKT signalling by benzoxazine derivative LTUR6 through the modulation of downstream kinases [0.03%]
苯氧嗪衍生物LTUR6通过调节下游激酶抑制AKT信号转导
Rejitha Suraj,Jasim Al-Rawi,Christopher Bradley
Rejitha Suraj
Many compounds structurally similar to chromones have been developed to enhance the sensitizing effect of cancer cells to chemotherapeutic agents. Most of these compounds have been shown to promote this sensitization by targeting the repair...
A phase I study of ontuxizumab, a humanized monoclonal antibody targeting endosialin, in Japanese patients with solid tumors [0.03%]
一项关于安图珠单抗(靶向内脏蛋白的全人源化单克隆抗体)治疗日本实体瘤患者的I期临床试验
Toshihiko Doi,Takeshi Aramaki,Hirofumi Yasui et al.
Toshihiko Doi et al.
Background We conducted a first-in-Japanese, phase I study of ontuxizumab, a humanized, anti-endosialin monoclonal antibody, to confirm its tolerability, safety, and pharmacokinetics, and identify exploratory efficacy. Methods This was a mu...
IMRT combined with S-1 concurrent chemoradiotherapy in locally advanced nasopharyngeal carcinoma: a prospective phase II study [0.03%]
同期放化疗序贯个体化巩固化疗治疗局部区域晚期鼻咽癌的前瞻性Ⅱ期临床研究
Tao Lv,Yujie Wang,Dan Ou et al.
Tao Lv et al.
Purpose The current standard treatment for locally advanced nasopharyngeal carcinoma (LANPC) is intensity-modulated radiation therapy (IMRT) plus cisplatin concurrent chemoradiotherapy (CCRT). However, this regimen has well-known hematologi...