Modular parallel plate flow chamber with tunable substrate mechanics and defined shear stress [0.03%]
可调基底力学和定义剪切应力的模块化平行平板流室
Bryan J Ferrick,Jason P Gleghorn
Bryan J Ferrick
Cells integrate multiple mechanical cues simultaneously, yet most in vitro models examine extracellular matrix (ECM) stiffness and fluid shear stress (FSS) in isolation, limiting our understanding of mechanotransduction. We developed a para...
"A nano-enabled screen-printed paper-based electrochemical device with a 3D-printed wristband cassette design for selective and real-time detection of club drug amphetamine in complex matrices" [0.03%]
“一种基于纳米的丝网印刷纸基电化学装置，配有3D打印的手腕带盒子设计，在复杂基质中进行选择性和实时检测摇头丸用苯胺”的英文标题
Nigar Anzar,Shariq Suleman,Suhel Parvez et al.
Nigar Anzar et al.
Increasing drug-facilitated crimes, mainly sexual assaults have intensified the necessity of accessible and efficient methods for club drugs detection especially in biological matrices and beverages that are served at parties and clubs. The...
Magnetically-guided, stimuli-responsive microdevices for endovascular therapy [0.03%]
磁导航刺激响应性微设备血管内治疗
Sanjay Manoharan,Vivek Subramanian
Sanjay Manoharan
Current endovascular aneurysm treatments rely on catheter-based delivery systems, which inherently restrict access to tortuous anatomies and small-caliber vessels. To address this limitation, we introduce a tetherless microdevice platform t...
Advances in microneedle Technology for Treatment of retinal degenerative diseases: a narrative review [0.03%]
用于治疗视网膜退行性疾病的微针技术进展：综述
Yuan Zong,Jiangman Liu,Mingming Yang et al.
Yuan Zong et al.
Retinal degenerative diseases, such as age-related macular degeneration (AMD) and diabetic retinopathy (DR), present significant therapeutic challenges due to the complex anatomical and physiological barriers of the posterior eye. Conventio...
Electrochemical biosensors for the detection of neurodegenerative diseases [0.03%]
用于检测神经退行性疾病的电化学生物传感器
Şeyma Erkaya,Kubra Tig,Ozge Deniz Yeşil Baysal et al.
Şeyma Erkaya et al.
This review focuses on the recent progress in electrochemical biosensors, which are emerging as innovative, sensitive, and cost-efficient platforms for identifying and monitoring biomarkers associated with neurodegeneration. We examine the ...
Ultra-Sensitive and direct detection of MiRNAs in real samples via duplex-specific nuclease-mediated signal amplification [0.03%]
基于核酸酶介导信号放大的miRNA直接检测新技术
Chun-Guang Yang,Yi Han,Jing-Jing Zhang et al.
Chun-Guang Yang et al.
The expression levels of miRNAs in cells or biological fluids are closely associated with the onset and progression of many diseases, making the detection of miRNAs in serum and plasma increasingly important. However, due to the low levels ...
Assessment of physicochemical alterations in 3D-printed biodegradable implants under biomimetic conditions for cranial defect repair [0.03%]
三维打印生物可降解植入物在颅骨缺损修复仿生条件下的理化变化评估
Eungtae Lee,Yeonguk Seong,Jihee Jeong et al.
Eungtae Lee et al.
Once implanted, biodegradable devices gradually deteriorate, potentially compromising clinical performance. Consequently, evaluating the alterations in physicochemical characteristics after implantation is crucial. Nonetheless, there is cur...
Balanced-armature-based, electromagnetic actuator for round window stimulation of the inner ear with static pre-load [0.03%]
基于平衡电枢的电磁致动器用于圆窗刺激耳蜗并施加静态预加载
Maren S Prediger,Eileen Müller,Anatoly Glukhovskoy et al.
Maren S Prediger et al.
Roughly 5% of the population is affected by hearing loss. In case of a functional middle ear impairment with decreased transmission, different types of active middle ear implants may restore hearing. To drive the round window membrane (RWM)...
Au-MnOx nanozyme-based multifunctional hydrogel for NIR-II laser triggered tumor radiotherapy sensitization [0.03%]
基于Au-MnOx纳米酶的多功能水凝胶用于近红外激光触发的肿瘤放射增敏治疗
Zhan Xiao,Xiaolong Zhou,Lingbo Zhang et al.
Zhan Xiao et al.
Radiotherapy (RT) is widely used for malignant tumors ablation in the clinic. However, redundant doses of X-rays might cause irreversible side effects in the periphery of tumor sites. To address this, the convergence of low-dose RT with a n...
3D-Printed CRISPR-based detection system powered by a reusable handwarmer [0.03%]
一种基于CRISPR的检测系统，由可重复使用的暖手器提供动力的3D打印装置
Daniel Schreiber,Rui Yang,Xin Guan et al.
Daniel Schreiber et al.
Nucleic acid-based molecular diagnostics are essential for the prevention, early detection, and treatment of cancer and infectious diseases. In this study, we developed a 3D-printed, electricity-free detection system for CRISPR-based nuclei...