A high-precision bendable ophthalmic microinjection needle fabricated by polypropylene-fiber-templated electroplating: process design and ex vivo validation [0.03%]
一种用于眼科微注射的高精度可弯曲电铸微针：聚丙烯纤维模板法的设计与活体外验证
Qiangsheng Fu,Xianshan Jin,Gang Chen et al.
Qiangsheng Fu et al.
Intravitreal and subretinal drug delivery require slender injection tools that reduce tissue trauma while maintaining lumen patency and mechanical reliability. This study describes a bendable ophthalmic microinjection needle fabricated usin...
Automated cell manipulation in multicellular environments by an optically induced dielectrophoresis system based on static optical traps and the A-star algorithm [0.03%]
基于静态光学陷阱和A星算法的光诱导介电泳系统在多细胞环境中实现自动化细胞操作
Yongqi Hu,Ying Wang,Tong Jiang et al.
Yongqi Hu et al.
Optically Induced Dielectrophoresis (ODEP) has been widely used in biomedical applications such as cell sorting and cell capture because of its operational flexibility and low cellular damage. However, existing automated ODEP methods often ...
A pump-free gravity-driven microfluidic chip for rapid RPA-LFS-based detection of Magnaporthe oryzae AvrPi9 gene [0.03%]
一种用于快速检测Magnaporthe oryzae AvrPi9基因的无泵重力驱动微流控芯片（基于重组酶聚合酶放大-滚环荧光扩增法）
Yu Ting Wu,Chatchawan Jantasuriyarat,Jyh Jian Chen
Yu Ting Wu
We present a pump-free, gravity-assisted microfluidic lab-on-a-chip platform for the rapid detection of the rice blast pathogen Magnaporthe oryzae by targeting the AvrPi9 gene. The system integrates precise thermal control, programmable flu...
Mechanotherapeutic biomaterials: Overcoming physical barriers to enhance intratumoral drug delivery in solid tumours [0.03%]
机械治疗生物材料：克服物理障碍以增强实体瘤内的药物递送
Fathe Singh
Fathe Singh
The clinical translation of nanomedicine for solid tumours remains limited despite substantial advances in biomaterial design and molecular targeting, primarily due to the physical inaccessibility of tumour tissue. Solid tumours exhibit a m...
Reversibly-sealable microfluidic platform for multi-molecule gradient delivery to large adherent cell cultures [0.03%]
用于向贴壁细胞大规模培养递送多分子梯度的可逆密封微流体平台
Julia Radzio,Łukasz Suprewicz,Da Kuang et al.
Julia Radzio et al.
Spatial manipulation of flow gradients and chemical microenvironments is essential for understanding fundamental biological mechanisms and investigating therapeutic responses in adherent cells. Convection-dominated gradient generators in mi...
3D printed chip as platform to vascularize hiPSCs-derived kidney organoids [0.03%]
基于hiPSC的肾脏类器官芯片的3D打印及血管化研究
Gabriele Addario,Chiara Formica,Lorenzo Moroni et al.
Gabriele Addario et al.
Human induced pluripotent stem cells (hiPSCs)-derived kidney organoids can resemble early stages of human kidney development, morphology and architecture. However, one of the main limitations of the organoids is the reduced vascularization,...
Ingestible smart capsules: from engineering innovation to GI drug delivery [0.03%]
可摄入式智能胶囊：从工程创新到胃肠道药物输送技术
Dilpreet Singh,Pallvi Kumari,Bishal Singh et al.
Dilpreet Singh et al.
Ingestible smart capsule platforms have achieved substantial engineering sophistication - integrating programmable drug release, real-time sensing, wireless telemetry, and on-demand actuation - yet their demonstrated clinical benefit in inf...
An inexpensive, portable, refrigeration-free, ready-to-use microfluidic device for real-time multiplexed molecular detection of HIV, HBV, and HCV [0.03%]
一种低成本的、便于携带的、无需制冷设备的即时微型流体装置，用于对HIV、HBV和HCV进行实时多重分子检测
Huiwen Bai,Sangmin Lee,Ruijie Li et al.
Huiwen Bai et al.
Human immunodeficiency virus (HIV), Hepatitis B virus (HBV), and Hepatitis C virus (HCV) have infected or co-infected more than 400 million people worldwide and are becoming one of the most significant challenges for global healthcare. A si...
A colorimetric glucose sensor with gradient porous polyglycolic acid (PGA) microneedle array patch [0.03%]
具有梯度多孔聚甘油酸(PGA)微针阵列贴片的色彩葡萄糖传感器
Yunfan Zhang,Zifan Xue,Boyu Qin et al.
Yunfan Zhang et al.
Rapid glucose detection holds significance to diabetes. Here, a novel colorimetric glucose sensor for interstitial fluid (ISF) glucose detection is proposed, comprising a gradient porous polyglycolic acid (PGA) microneedle array patch (MAP)...
A needle-free bubble injector enabling depth-controlled isotropic and anisotropic perforation using electrically induced bubbles and heat generated by electric discharge [0.03%]
一种无针气泡注射器，可在电气放电产生的等深定向和非定向穿孔中利用电气产生气泡和热量
Yuudai Aokusa,Nobutoshi Ota,Shigeaki Miura et al.
Yuudai Aokusa et al.
Transdermal drug delivery is advantageous in administering therapeutic agents, such as many vaccines and macromolecular drugs that do not remain in the body after oral ingestion. Needle-free injectors have been developed as an alternative t...