Design and biological evaluation of a histidine-bearing cyclometalated Pd(II) complex derived from 2-phenylpyridine [0.03%]
基于2-苯基吡啶的含组氨酸环金属钯(II)配合物的设计与生物活性研究
Sedigheh Abedanzadeh
Sedigheh Abedanzadeh
A rationally designed approach was employed to synthesize a new C^N-cyclometalated Pd(II) complex (C^N = 2-phenylpyridine) as a potential anticancer metallodrug. The incorporation of histidine in the coordination sphere of metal complex off...
Association between metal co-exposure and frailty: exploring the potential explanatory pathway of inflammation [0.03%]
金属联合暴露与衰弱的相关性：探索炎症的潜在解释路径
Dongmei Yu,Yue Wei,Yan-Feng Zhou et al.
Dongmei Yu et al.
Frailty is a critical geriatric syndrome associated with disability and mortality, yet the associations and mechanisms between environmental metal co-exposure with frailty remain unclear. This cross-sectional study included 4484 adults aged...
Evaluation of aluminum absorption in Caenorhabditis elegans: pre-treatment optimization and the impact of dose and population size [0.03%]
钙视网膜菌中铝吸收的评估：预处理优化和剂量及群体大小的影响
Dilara Ülger Özbek,Yoncagül Nar,Şeyda Berk et al.
Dilara Ülger Özbek et al.
Accurate quantification of aluminum (Al) uptake is essential for evaluating metal toxicity in experimental models. This study aimed to optimize pretreatment strategies and determine the effects of individual number and dose on Al accumulati...
Recent advances in therapeutic agents for uranium poisoning: a comprehensive review [0.03%]
铀中毒治疗药物的最新进展：综述
Juan Li,Wenrun Li,Feng Huang et al.
Juan Li et al.
Uranium-an emerging pollutant that exhibits both radioactivity and heavy metal toxicity-is extensively used in nuclear fuel and military applications. Occupational and environmental exposure during its extraction, production, and utilizatio...
Thaís Dos Santos Berón,Gustavo Rossato Bitencourt,Rochele Sogari Picoloto et al.
Thaís Dos Santos Berón et al.
This study evaluated the bioaccessibility of essential (Ca, Cu, Fe, K, Mg, Mn, Mo, Na and Zn) and non-essential (Al, Ba, Cr, Sr and V) elements in food supplements (vitamins and/or minerals and botanicals). Extraction using in-vitro methods...
Janna Markov,Zohar Shpilt Mayer,Adi Ticher et al.
Janna Markov et al.
Chronic, sub-toxic, multi-metal accumulation stemming from environmental exposure in daily life is a common phenomenon in modern humans and has been linked to numerous diseases. Toxic metals found in leukemia patients have recently been lin...
Integrative physiological and metabolomic study of Hirschfeldia incana under short- and medium-term lead (Pb) stress [0.03%]
短期和中期铅胁迫对拟芥菜（Hirschfeldia incana）生理和代谢组的综合研究
Oumaima El Khattabi,Abdelaziz Smouni,Pierre Pétriacq et al.
Oumaima El Khattabi et al.
Physiological and metabolic responses of the Pb-tolerant Brassicaceae Hirschfeldia incana to short-term (3 days) and medium-term (15 days) Pb exposure were evaluated. Physiological traits revealed an early and sustained control of oxidative...
Conjugates of desferrioxamine with 5-aminolevulinic or γ-aminobutyric acid: synthesis, theoretical studies, iron-chelating ability, and penetration in human Caco-2 cells [0.03%]
与5-氨基乙醛酸或γ-氨基丁酸结合的去铁敏衍生物：合成、理论研究、螯合铁能力及在人Caco-2细胞中的穿透性
Ernani Lacerda,Vasilii D Khripun,M Teresa Machini et al.
Ernani Lacerda et al.
Iron overload (IO) is a harmful condition in humans that promotes oxidative damage to DNA and lipids. As IO has been associated with the onset of neurodegenerative diseases (NDs), chelation therapy has been extensively used for treating IO ...
Fine-tuning alkyl chain length in copper(II) complexes: effects on DNA binding and catalytic cleavage [0.03%]
通过调节烷基链长度对铜（II）配合物进行精制：对DNA结合和催化裂解的影响
Maiara I N Dos Santos,Matheus S S Paqui,Giliandro Farias et al.
Maiara I N Dos Santos et al.
Metal complexes are well known for their DNA cleavage activity. Copper is a metal that stands out for this purpose because it is able to perform cleavage through oxidative mechanisms using the Haber-Weiss cycle. We report two unprecedented ...
Unveiling the pathogenesis and therapeutic strategies of Alzheimer's disease through cuproptosis [0.03%]
通过铜死亡揭示阿尔茨海默病的发病机制和治疗策略
Shuangfeng Xu,Jing Mu,Zhifeng Wang et al.
Shuangfeng Xu et al.
Alzheimer's disease (AD), a leading cause of dementia, remains incurable, necessitating novel insights into its pathogenesis and therapeutic strategies. Recent studies highlight cuproptosis-a copper (Cu)-dependent mitochondrial cell death p...