Synthesis of symmetrical and unsymmetrical tetrahydroxybiphenyls and their evaluation as amyloid-β aggregation inhibitors [0.03%]
对称和非对称四羟基茋的合成及其抑制淀粉样蛋白-β聚集作用的研究
Sarah L Wicks,Jake A Roberts,Matthew J Hurtt et al.
Sarah L Wicks et al.
Our group recently reported that the polyhydroxy aromatic compound 3,3',4,4'-biphenyltetrol (2a) is a successful inhibitor of amyloid-β peptide (Aβ) aggregation, decreasing Aβ aggregation by 50 % when present in equimolar concentrations....
Chiral Allenylcarbonyls - Underexploited Building Blocks for Complex Synthesis [0.03%]
用于复杂合成的艾丁基羰基类手性砌块：有待开发的研究领域
Krishna Yadavalli,Salvatore D Lepore
Krishna Yadavalli
Chiral allenylcarbonyls such as allenoates remain underutilized in complex synthesis despite recent advances in synthesis methods to prepare them non-racemically. The field is now ripe for the employment of this class of allenes as building...
Carbon-Carbon Bond Formation Facilitated by π-Complexed Organometallic Auxiliaries: An Overview [0.03%]
π配合 organometallic 助催化剂促进的碳氢键活化及偶联反应综述
Animesh Roy,Bilal A Bhat,Salvatore D Lepore
Animesh Roy
Organometallic moieties attached to substrates via π-complexation play an important role as auxiliaries. As described in the present review, η-linked auxiliaries have been employed to overcome numerous synthesis obstacles that continue to...
An Efficient Oxidation of Alcohols by Aqueous H2O2 with 1,3-Dibromo-5,5-Dimethylhydantoin [0.03%]
用水合氧化氢和1,3-二溴-5,5-二甲基乙内酰脲高效催化醇类氧化反应
Jieun Lee,Jong Chan Lee
Jieun Lee
An efficient protocol is described for the oxidation of alcohols to the corresponding aldehydes or ketones with 1,3-dibromo-5,5-dimethylhydantoin in the presence of aqueous H2O2. ...
Direct Oxidation of Aldehydes to Methyl Esters with Urea Hydrogen Peroxide and p-Toluenesulfonyl Chloride [0.03%]
尿素过氧化氢和对甲苯磺酰氯催化醛的直接酯化反应生成甲基酯
Deuk Jun Jeong,Su Bin Lee,Jong Chan Lee
Deuk Jun Jeong
Combination of urea hydrogen peroxide and p-toluenesulfonyl chloride in methanol was proved to be facile and highly efficient for the oxidative methyl esterification of various aldehydes to the corresponding carboxylic methyl esters. ...
A Short Route to the Ester (±) HomoSarkomycin via Johnson-Claisen Rearrangement [0.03%]
简短的Johnson-Claisen重排合成(±)Homo沙珂霉素酯的方法
M Saied,Rafik Gatri,Abdullah Sulaiman Al-Ayed et al.
M Saied et al.
Background: α-Methylene cycloalkanones are considered of interest because of their biological activity. Herein, in this paper the synthesis of (±) HomoSarkomycine Esters was described and characterized. ...
FledFold: A Novel Software for RNA Secondary Structure Prediction [0.03%]
FledFold：一种用于RNA二级结构预测的新型软件
Qi Zhao,Yuanning Liu,Yunna Duan et al.
Qi Zhao et al.
Background: RNA secondary structure is essential to understand the mechanism of RNAs. Method: In this paper, fledFold, a novel software...
Visualization of Hyperconjugation and Subsequent Structural Distortions through 3D Printing of Crystal Structures [0.03%]
通过晶体质谱的3D打印可视化超强共轭和随后的结构变形
Farha J Mithila,Stephanie Oyola-Reynoso,Martin M Thuo et al.
Farha J Mithila et al.
Background: Structural distortions due to hyperconjugation in organic molecules, like norbornenes, are well captured through X-ray crystallographic data, but are sometimes difficult to visualize especially for those apply...
J Pablo García Merinos,Heraclio López Ruíz,Yliana López et al.
J Pablo García Merinos et al.
Triethylborane (TEB) was found to be a mild, efficient, and acid catalyst in electrophilic substitution reaction of indoles with aldehydes compounds to afford the corresponding bis(indolyl)methanes. Vibrindole A (5) and bis(indolyl)methanes...
Synthesis and Evaluation of an O-Aminated Naphthol AS-E as a Prodrug of CREB-mediated Gene Transcription Inhibition [0.03%]
合成和评估作为CREB介导的基因转录抑制剂CREB介导的基因转录抑制前药的O-氨基化萘酚AS-E
Fuchun Xie,Bingbing X Li,Xiangshu Xiao
Fuchun Xie
An O-aminated naphthol AS-E was designed as a prodrug to achieve reductive activation and improved aqueous solubility. During the synthesis of this designed compound, a novel transformation from aryl triflates and ethyl acetohydroximate to ...