Proteomic Changes Between Populus Allotriploids and Diploids Revealed Using an iTRAQ-based Quantitative Approach [0.03%]
基于iTRAQ的定量分析杨树异源三倍体和二倍体蛋白质组变化
Yi Wang,Yun Li,Yujing Suo et al.
Yi Wang et al.
Background: Polyploid breeding is a powerful approach for Populus genetic improve-ment because polyploid trees have valuable characteristics, including better timber quality and a higher degree of stress resistance compar...
Identification of Osteoporosis-Associated Protein Biomarkers from Ovariectomized Rat Urine [0.03%]
卵巢切除雌鼠尿液中与骨质疏松症相关的蛋白质生物标志物的鉴定
Jinkyu Lim,Sunil Hwang
Jinkyu Lim
Objective: Osteoporotic fracture is one of the most common health risks and aggravates the quality of life among postmenopausal women worldwide. In this study, osteoporosis-associated protein biomarkers were identified fr...
Gregory O Staples,Joseph Zaia
Gregory O Staples
The glycosaminoglycans (GAGs) are linear polysaccharides expressed on animal cell surfaces and in extracellular matrices. Their biosynthesis is under complex control and confers a domain structure that is essential to their ability to bind ...
Ganesaratnam K Balendiran,J Rajendran Pandian,Evin Drake et al.
Ganesaratnam K Balendiran et al.
The NADPH-dependent reduction of glucose reaction that is catalyzed by Aldose Reductase (AR) follows a sequential ordered kinetic mechanism in which the co-factor NADPH binds to the enzyme prior to the aldehyde substrate. The kinetic/struct...
Cristiana Pistol Tanase,Ana-Maria Enciu,Simona Mihai et al.
Cristiana Pistol Tanase et al.
High grade gliomas represent one of the most aggressive and treatment-resistant types of human cancer, with only 1-2 years median survival rate for patients with grade IV glioma. The treatment of glioblastoma is a considerable therapeutic c...
Immunomics in Skin Cancer - Improvement in Diagnosis, Prognosis and Therapy Monitoring [0.03%]
皮肤癌免疫组学在诊断、预后和治疗监测方面的改进
Amanda Bulman,Monica Neagu,Carolina Constantin
Amanda Bulman
This review will focus on the elements of the skin's immune system, immune cells and/or non-immune cells that support immune mechanisms, molecules with immune origin and/or immune functions that are involved in skin carcinogenesis. All thes...
Kai Xu,Peter D Nagy
Kai Xu
Plant viruses exploit cellular factors, including host proteins, membranes and metabolites, for their replication in infected cells and to establish systemic infections. Besides traditional genetic, molecular, cellular and biochemical metho...
Bioinformatics Tools for Mass Spectrometry-Based High-Throughput Quantitative Proteomics Platforms [0.03%]
基于质谱的高通量定量蛋白质组平台的生物信息学工具
Alexey V Nefedov,Miroslaw J Gilski,Rovshan G Sadygov
Alexey V Nefedov
Determining global proteome changes is important for advancing a systems biology view of cellular processes and for discovering biomarkers. Liquid chromatography, coupled to mass spectrometry, has been widely used as a proteomics technique ...
Structural Characterization of Carbohydrates by Fourier Transform Tandem Mass Spectrometry [0.03%]
傅里叶变换串联质谱法对碳水化合物的结构表征
Wen Zhou,Kristina Håkansson
Wen Zhou
Fourier transform tandem mass spectrometry (MS/MS) provides high mass accuracy, high sensitivity, and analytical versatility and has therefore emerged as an indispensable tool for structural elucidation of biomolecules. Glycosylation is one...
Stephen P Holly,Xian Chen,Leslie V Parise
Stephen P Holly
Human platelets are thought to express approximately 2000-3000 proteins, but post-translational modifications, alternatively spliced variants and a rich diversity of vertebrate domain architectures likely make this a conservative estimate. ...